Plant-derived chelators and ionophores as potential therapeutics for metabolic diseases.
Journal
Chemical Society reviews
ISSN: 1460-4744
Titre abrégé: Chem Soc Rev
Pays: England
ID NLM: 0335405
Informations de publication
Date de publication:
06 Jun 2023
06 Jun 2023
Historique:
pmc-release:
06
06
2024
medline:
8
6
2023
pubmed:
19
5
2023
entrez:
19
5
2023
Statut:
epublish
Résumé
Transition metal dysregulation is associated with a host of pathologies, many of which are therapeutically targeted using chelators and ionophores. Chelators and ionophores are used as therapeutic metal-binding compounds which impart biological effects by sequestering or trafficking endogenous metal ions in an effort to restore homeostasis. Many current therapies take inspiration or derive directly from small molecules and peptides found in plants. This review focuses on plant-derived small molecule and peptide chelators and ionophores that can affect metabolic disease states. Understanding the coordination chemistry, bioavailability, and bioactivity of such molecules provides the tools to further research applications of plant-based chelators and ionophores.
Identifiants
pubmed: 37203389
doi: 10.1039/d3cs00167a
pmc: PMC10281457
mid: NIHMS1903500
doi:
Substances chimiques
Ionophores
0
Chelating Agents
0
Metals
0
Transition Elements
0
Peptides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3927-3945Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM133684
Pays : United States
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