Antigen-specific and cross-reactive T cells in protection and disease.
T-cell cross-reactivity
antigen-specific T cells
cancer
infection
neurodegenerative diseases
vaccination
Journal
Immunological reviews
ISSN: 1600-065X
Titre abrégé: Immunol Rev
Pays: England
ID NLM: 7702118
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
revised:
25
04
2023
received:
01
04
2023
accepted:
27
04
2023
pmc-release:
01
07
2024
medline:
21
7
2023
pubmed:
20
5
2023
entrez:
20
5
2023
Statut:
ppublish
Résumé
Human T cells have a diverse T-cell receptor (TCR) repertoire that endows them with the ability to identify and defend against a broad spectrum of antigens. The universe of possible antigens that T cells may encounter, however, is even larger. To effectively surveil such a vast universe, the T-cell repertoire must adopt a high degree of cross-reactivity. Likewise, antigen-specific and cross-reactive T-cell responses play pivotal roles in both protective and pathological immune responses in numerous diseases. In this review, we explore the implications of these antigen-driven T-cell responses, with a particular focus on CD8+ T cells, using infection, neurodegeneration, and cancer as examples. We also summarize recent technological advances that facilitate high-throughput profiling of antigen-specific and cross-reactive T-cell responses experimentally, as well as computational biology approaches that predict these interactions.
Identifiants
pubmed: 37209375
doi: 10.1111/imr.13217
pmc: PMC10524458
mid: NIHMS1901385
doi:
Substances chimiques
Antigens
0
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
120-135Subventions
Organisme : NCI NIH HHS
ID : R33 CA225539
Pays : United States
Organisme : NCI NIH HHS
ID : R33 CA256086
Pays : United States
Informations de copyright
© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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