The sensitivity of the zebrafish embryo coiling assay for the detection of neurotoxicity by compounds with diverse modes of action.
Alternative test method
Behavior profiling
Danio rerio
Developmental toxicity testing
Locomotor assay
Spontaneous tail movement
Journal
Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
25
11
2022
accepted:
11
05
2023
medline:
28
6
2023
pubmed:
22
5
2023
entrez:
22
5
2023
Statut:
ppublish
Résumé
In the aim to determine neurotoxicity, new methods are being validated, including tests and test batteries comprising in vitro and in vivo approaches. Alternative test models such as the zebrafish (Danio rerio) embryo have received increasing attention, with minor modifications of the fish embryo toxicity test (FET; OECD TG 236) as a tool to assess behavioral endpoints related to neurotoxicity during early developmental stages. The spontaneous tail movement assay, also known as coiling assay, assesses the development of random movement into complex behavioral patterns and has proven sensitive to acetylcholine esterase inhibitors at sublethal concentrations. The present study explored the sensitivity of the assay to neurotoxicants with other modes of action (MoAs). Here, five compounds with diverse MoAs were tested at sublethal concentrations: acrylamide, carbaryl, hexachlorophene, ibuprofen, and rotenone. While carbaryl, hexachlorophene, and rotenone consistently induced severe behavioral alterations by ~ 30 h post fertilization (hpf), acrylamide and ibuprofen expressed time- and/or concentration-dependent effects. At 37-38 hpf, additional observations revealed behavioral changes during dark phases with a strict concentration-dependency. The study documented the applicability of the coiling assay to MoA-dependent behavioral alterations at sublethal concentrations, underlining its potential as a component of a neurotoxicity test battery.
Identifiants
pubmed: 37213015
doi: 10.1007/s11356-023-27662-2
pii: 10.1007/s11356-023-27662-2
pmc: PMC10293418
doi:
Substances chimiques
Rotenone
03L9OT429T
Carbaryl
R890C8J3N1
Hexachlorophene
IWW5FV6NK2
Ibuprofen
WK2XYI10QM
Acrylamides
0
Water Pollutants, Chemical
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
75281-75299Subventions
Organisme : Horizon 2020
ID : 681002
Informations de copyright
© 2023. The Author(s).
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