The effect of exercise on cerebral blood flow and executive function among young adults: a double-blinded randomized controlled trial.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 05 2023
22 05 2023
Historique:
received:
24
01
2023
accepted:
06
04
2023
medline:
24
5
2023
pubmed:
23
5
2023
entrez:
22
5
2023
Statut:
epublish
Résumé
Studies have demonstrated that exercise benefits executive function. However, it remains unclear which type of exercise is optimal for preserving executive function among young adults and the cerebral blood flow (CBF) mechanisms that underlie exercise-induced cognitive benefits. Therefore, this study aims to compare the intervention effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on executive function and the CBF mechanism. This was a double-blinded, randomized, controlled trial study conducted between October 2020 and January 2021 (ClinicalTrials.gov identifier: NCT04830059). Ninety-three healthy young adults (25.23 ± 2.18 years old; 49.82% male) were randomized into the HIIT (N = 33), MICT (N = 32), and control (N = 28) groups. Participants in exercise groups were guided to perform 40 min of HIIT and MICT three times a week for 12 weeks, while the control group received health education for the same period. The primary outcomes, changes in executive function assessed by the trail-making test (TMT), and CBF measured by transcranial Doppler flow analyzer (EMS-9WA), were evaluated before and after the interventions. The time taken to complete the TMT task improved significantly in the MICT group compared to the control group [β = -10.175, 95%, confidence interval (CI) = -20.320, -0.031]. Additionally, the MICT group showed significant improvements in the pulsatility index (PI) (β = 0.120, 95% CI = 0.018, 0.222), resistance index (RI) (β = 0.043, 95% CI = 0.005, 0.082), and peak-systolic/end-diastolic velocity (S/D) (β = 0.277, 95% CI = 0.048, 0.507) of CBF compared to the control group. The time taken to complete the TMT was associated with the velocity of peak-systolic (F = 5.414, P = 0.022), PI (F = 4.973, P = 0.012), and RI (F = 5.845, P = 0.006). Furthermore, the accuracy of TMT was associated with PI (F = 4.797, P = 0.036), RI (F = 5.394, P = 0.024), and S/D (F = 4.312, P = 0.05) of CBF. A 12-week MICT intervention improved CBF and executive function more effectively than HIIT among young adults. Furthermore, the findings suggest that CBF was one of the potential mechanisms underlying the cognitive benefits of exercise in young people. These results provide practical evidence supporting the promotion of regular exercise to maintain executive function and improve brain health.
Identifiants
pubmed: 37217511
doi: 10.1038/s41598-023-33063-9
pii: 10.1038/s41598-023-33063-9
pmc: PMC10203129
doi:
Banques de données
ClinicalTrials.gov
['NCT04830059']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8269Informations de copyright
© 2023. The Author(s).
Références
Acta Anaesthesiol Scand. 2009 Nov;53(10):1324-8
pubmed: 19650800
Neuroimage. 2010 Feb 1;49(3):2756-63
pubmed: 19853041
J Exerc Sci Fit. 2022 Jan;20(1):40-47
pubmed: 34987589
BMC Geriatr. 2010 Apr 01;10:16
pubmed: 20359355
J Neuroimaging. 2013 Jul;23(3):466-72
pubmed: 23157483
Eur J Appl Physiol. 2016 Jul;116(7):1313-9
pubmed: 27150353
J Sci Med Sport. 2019 May;22(5):596-601
pubmed: 30509862
Neurosci Biobehav Rev. 2013 Nov;37(9 Pt B):2243-57
pubmed: 23623982
Neurobiol Aging. 2010 Dec;31(12):2047-57
pubmed: 19111937
Neuroimage. 2016 May 1;131:73-80
pubmed: 26477649
Ann N Y Acad Sci. 2007 Nov;1118:122-41
pubmed: 17717092
J Strength Cond Res. 2013 Dec;27(12):3300-9
pubmed: 23442271
Neurology. 2020 May 26;94(21):e2245-e2257
pubmed: 32404355
Sci Rep. 2021 Nov 11;11(1):22061
pubmed: 34764358
Sports Med. 2015 May;45(5):679-92
pubmed: 25771785
Med Sci Sports Exerc. 2016 Oct;48(10):1985-93
pubmed: 27187097
Am Heart J. 1973 Apr;85(4):546-62
pubmed: 4632004
J Educ Eval Health Prof. 2021;18:17
pubmed: 34325496
Physiol Behav. 2018 Dec 1;197:22-28
pubmed: 30248301
Neurosci Res. 2006 Mar;54(3):186-91
pubmed: 16364480
J Alzheimers Dis. 2019;67(2):671-684
pubmed: 30636734
Med Sci Sports Exerc. 2007 Jan;39(1):103-7
pubmed: 17218891
PLoS One. 2011;6(10):e26812
pubmed: 22046366
J Neuroimaging. 2001 Jul;11(3):229-35
pubmed: 11462287
Handb Clin Neurol. 2021;176:ix
pubmed: 33272413
Proc R Soc Med. 1974 Jun;67(6 Pt 1):447-9
pubmed: 4850636
Int J Environ Res Public Health. 2020 Nov 06;17(21):
pubmed: 33172145
Eur J Appl Physiol. 2013 Oct;113(10):2531-40
pubmed: 23824463
Age (Dordr). 2013 Jun;35(3):905-20
pubmed: 22669592
Med Sci Sports Exerc. 1982;14(5):377-81
pubmed: 7154893
J Exerc Sci Fit. 2018 Dec;16(3):106-111
pubmed: 30662503
Neurobiol Learn Mem. 2010 Oct;94(3):364-72
pubmed: 20800689
Exerc Sport Sci Rev. 2009 Jul;37(3):123-9
pubmed: 19550203
Sports Med. 2007;37(2):145-68
pubmed: 17241104
J Neurol Sci. 2000 Aug 1;177(1):41-7
pubmed: 10967181
J Physiol. 2020 Jul;598(13):2513-2530
pubmed: 32347544
J Neurosci Methods. 2011 Mar 30;196(2):221-37
pubmed: 21276818
J Cereb Blood Flow Metab. 1992 Jan;12(1):110-9
pubmed: 1370068
J Physiol. 2008 Aug 15;586(16):4005-10
pubmed: 18635643
J Appl Physiol (1985). 2018 Sep 1;125(3):790-798
pubmed: 29878870
Brain Sci. 2020 Oct 29;10(11):
pubmed: 33137993
J Cereb Blood Flow Metab. 2016 Apr;36(4):647-64
pubmed: 26661243
J Physiother. 2020 Jan;66(1):9-18
pubmed: 31843427
Health Psychol. 2011 Jan;30(1):91-8
pubmed: 21299297
Med Sci Sports Exerc. 2015 Jul;47(7):1460-9
pubmed: 25304335
J Sports Sci. 2021 Jan;39(1):10-22
pubmed: 32780634
J Behav Med. 2017 Apr;40(2):307-319
pubmed: 27544393
Cochrane Database Syst Rev. 2018 Jan 29;1:CD009728
pubmed: 29376563
Cell Metab. 2011 Dec 7;14(6):724-38
pubmed: 22152301
Hypertension. 2008 Feb;51(2):203-10
pubmed: 18086954
Nat Rev Cardiol. 2018 Dec;15(12):731-743
pubmed: 30115967
Prog Neurobiol. 2000 Jul;61(4):397-414
pubmed: 10727781
Adv Physiol Educ. 2015 Jun;39(2):55-62
pubmed: 26031719
J Exerc Sci Fit. 2022 Oct;20(4):291-304
pubmed: 35892114
West J Nurs Res. 2013 Jan;35(1):24-38
pubmed: 21911546
J Sports Sci. 2020 Dec;38(23):2637-2660
pubmed: 32783695
Mol Med Rep. 2016 Apr;13(4):2981-90
pubmed: 26934837
Prev Med Rep. 2015 Nov 14;2:973-9
pubmed: 26844177
Nat Rev Neurosci. 2008 Jan;9(1):58-65
pubmed: 18094706
J Cogn Neurosci. 2017 Nov;29(11):1895-1907
pubmed: 28699808
J Exp Child Psychol. 2013 May;115(1):188-97
pubmed: 23403228
Psychon Bull Rev. 2013 Feb;20(1):73-86
pubmed: 23229442
Ann Intern Med. 2018 Jan 2;168(1):30-38
pubmed: 29255839
Front Physiol. 2018 Nov 21;9:1657
pubmed: 30519192
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3017-22
pubmed: 21282661
Dtsch Arztebl Int. 2018 Feb 23;115(8):117-123
pubmed: 29526182
Neuropsychology. 2015 Jan;29(1):1-9
pubmed: 25068671
J Neuroimaging. 2020 Jan;30(1):76-81
pubmed: 31750593
Curr Pharm Des. 2015;21(25):3570-81
pubmed: 26166612
Front Psychiatry. 2022 Dec 14;13:1067890
pubmed: 36590621
Appl Physiol Nutr Metab. 2020 Jun;45(6):591-600
pubmed: 31665610