Serotonin sensing by microglia conditions the proper development of neuronal circuits and of social and adaptive skills.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
24
05
2022
accepted:
22
03
2023
revised:
17
03
2023
medline:
30
10
2023
pubmed:
23
5
2023
entrez:
22
5
2023
Statut:
ppublish
Résumé
The proper maturation of emotional and sensory circuits requires fine-tuning of serotonin (5-HT) level during early postnatal development. Consistently, dysfunctions of the serotonergic system have been associated with neurodevelopmental psychiatric diseases, including autism spectrum disorders (ASD). However, the mechanisms underlying the developmental effects of 5-HT remain partially unknown, one obstacle being the action of 5-HT on different cell types. Here, we focused on microglia, which play a role in brain wiring refinement, and we investigated whether the control of these cells by 5-HT is relevant for neurodevelopment and spontaneous behaviors in mice. Since the main 5-HT sensor in microglia is the 5-HT
Identifiants
pubmed: 37217677
doi: 10.1038/s41380-023-02048-5
pii: 10.1038/s41380-023-02048-5
doi:
Substances chimiques
Serotonin
333DO1RDJY
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2328-2342Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Limited.
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