Impaired Speaking-Induced Suppression in Alzheimer's Disease.
Alzheimer’s disease
efference copy
magnetoencephalography
speaking-induced suppression
state feedback control model
Journal
eNeuro
ISSN: 2373-2822
Titre abrégé: eNeuro
Pays: United States
ID NLM: 101647362
Informations de publication
Date de publication:
06 2023
06 2023
Historique:
received:
17
02
2023
accepted:
04
04
2023
medline:
8
6
2023
pubmed:
24
5
2023
entrez:
23
5
2023
Statut:
epublish
Résumé
Alzheimer's disease (AD) is a neurodegenerative disease involving cognitive impairment and abnormalities in speech and language. Here, we examine how AD affects the fidelity of auditory feedback predictions during speaking. We focus on the phenomenon of speaking-induced suppression (SIS), the auditory cortical responses' suppression during auditory feedback processing. SIS is determined by subtracting the magnitude of auditory cortical responses during speaking from listening to playback of the same speech. Our state feedback control (SFC) model of speech motor control explains SIS as arising from the onset of auditory feedback matching a prediction of that feedback onset during speaking, a prediction that is absent during passive listening to playback of the auditory feedback. Our model hypothesizes that the auditory cortical response to auditory feedback reflects the mismatch with the prediction: small during speaking, large during listening, with the difference being SIS. Normally, during speaking, auditory feedback matches its predictions, then SIS will be large. Any reductions in SIS will indicate inaccuracy in auditory feedback prediction not matching the actual feedback. We investigated SIS in AD patients [
Identifiants
pubmed: 37221089
pii: ENEURO.0056-23.2023
doi: 10.1523/ENEURO.0056-23.2023
pmc: PMC10249944
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : R01 NS100440
Pays : United States
Organisme : NIA NIH HHS
ID : F32 AG050434
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG019724
Pays : United States
Organisme : NIA NIH HHS
ID : K23 AG038357
Pays : United States
Organisme : NIA NIH HHS
ID : K08 AG058749
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC010145
Pays : United States
Organisme : NIDCD NIH HHS
ID : K24 DC015544
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS076171
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC017091
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC017696
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB022717
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS050915
Pays : United States
Organisme : NIDCD NIH HHS
ID : P50 DC019900
Pays : United States
Informations de copyright
Copyright © 2023 Kim et al.
Déclaration de conflit d'intérêts
The authors declare no competing financial interests.
Références
J Neural Eng. 2019 Nov 12;16(6):066045
pubmed: 31476752
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
J Neurosci. 2017 Sep 20;37(38):9249-9258
pubmed: 28842410
Front Hum Neurosci. 2011 Oct 25;5:82
pubmed: 22046152
Curr Opin Neurobiol. 2015 Aug;33:174-81
pubmed: 25989242
Int J Psychophysiol. 2012 Feb;83(2):232-9
pubmed: 21959054
J Neurosci. 2013 Oct 9;33(41):16110-6
pubmed: 24107944
Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2653-8
pubmed: 23345447
Neuroimage. 2018 Jan 15;165:35-47
pubmed: 28966084
Front Hum Neurosci. 2018 Mar 06;12:82
pubmed: 29559903
Eur J Nucl Med Mol Imaging. 2006 Jul;33(7):801-9
pubmed: 16550383
Ann Neurol. 2001 Apr;49(4):433-42
pubmed: 11310620
J Cogn Neurosci. 2002 Nov 15;14(8):1125-38
pubmed: 12495520
J Clin Exp Neuropsychol. 2018 Nov;40(9):917-939
pubmed: 29669461
Neurology. 1993 Nov;43(11):2412-4
pubmed: 8232972
Am J Alzheimers Dis Other Demen. 2007 Dec-2008 Jan;22(6):474-88
pubmed: 18166607
Ann Neurol. 2012 May;71(5):668-86
pubmed: 22522481
Neuropsychologia. 2017 Jul 1;101:106-114
pubmed: 28461225
Brain. 2006 Nov;129(Pt 11):2885-93
pubmed: 17008332
Brain. 2007 Apr;130(Pt 4):1159-66
pubmed: 17353226
Hum Brain Mapp. 2016 Apr;37(4):1474-85
pubmed: 26917046
Neuroimage. 2014 Feb 1;86:525-35
pubmed: 24076223
Front Hum Neurosci. 2021 May 20;15:642819
pubmed: 34093150
Clin Interv Aging. 2015 Aug 27;10:1401-7
pubmed: 26346123
Front Hum Neurosci. 2010 Mar 22;4:25
pubmed: 20631856
Neurobiol Aging. 2017 Apr;52:71-80
pubmed: 28131013
Neuron. 2011 Feb 10;69(3):407-22
pubmed: 21315253
Sci Rep. 2019 Apr 5;9(1):5686
pubmed: 30952883
EClinicalMedicine. 2020 Oct 22;28:100583
pubmed: 33294808
Neurobiol Aging. 2003 Mar-Apr;24(2):221-31
pubmed: 12498956
J Neurol Neurosurg Psychiatry. 2002 Dec;73(6):657-64
pubmed: 12438466
AJNR Am J Neuroradiol. 2005 Feb;26(2):333-40
pubmed: 15709131
Brain. 2004 Mar;127(Pt 3):628-49
pubmed: 14761903
J Neurosci. 2013 Mar 27;33(13):5439-53
pubmed: 23536060
Methods. 2001 Oct;25(2):249-71
pubmed: 11812209
Neuroimage. 2008 Feb 1;39(3):1429-43
pubmed: 18035557
BMC Neurosci. 2009 Jun 13;10:58
pubmed: 19523234
Front Aging Neurosci. 2015 Oct 20;7:195
pubmed: 26539107
Neuroimage. 2018 Oct 1;179:326-336
pubmed: 29936308
Ann N Y Acad Sci. 1984;425:743-52
pubmed: 6331246
J Neural Eng. 2016 Jun;13(3):036007
pubmed: 27064933
J Acoust Soc Am. 2019 May;145(5):EL372
pubmed: 31153297
Neuroimage. 2001 Aug;14(2):298-309
pubmed: 11467904
Neuron. 2012 Feb 23;73(4):842-53
pubmed: 22365555