An association of CSF apolipoprotein E glycosylation and amyloid-beta 42 in individuals who carry the APOE4 allele.
Alzheimer’s disease
Apolipoprotein E
Glycan
Isoform
Mass spectrometry
Journal
Alzheimer's research & therapy
ISSN: 1758-9193
Titre abrégé: Alzheimers Res Ther
Pays: England
ID NLM: 101511643
Informations de publication
Date de publication:
23 05 2023
23 05 2023
Historique:
received:
26
08
2022
accepted:
05
05
2023
medline:
25
5
2023
pubmed:
24
5
2023
entrez:
23
5
2023
Statut:
epublish
Résumé
Carrying the apolipoprotein E (ApoE) Ɛ4 allele is associated with an increased risk of cerebral amyloidosis and late-onset Alzheimer's disease, but the degree to which apoE glycosylation affects its development is not clear. In a previous pilot study, we identified distinct total and secondary isoform-specific cerebral spinal fluid (CSF) apoE glycosylation profiles, with the E4 isoform having the lowest glycosylation percentage (E2 > E3 > E4). In this work, we extend the analysis to a larger cohort of individuals (n = 106), utilizing matched plasma and CSF samples with clinical measures of AD biomarkers. The results confirm the isoform-specific glycosylation of apoE in CSF, resulting from secondary CSF apoE glycosylation patterns. CSF apoE glycosylation percentages positively correlated with CSF Aβ
Identifiants
pubmed: 37221560
doi: 10.1186/s13195-023-01239-0
pii: 10.1186/s13195-023-01239-0
pmc: PMC10204298
doi:
Substances chimiques
amyloid beta-protein (1-42)
0
Apolipoprotein E4
0
Apolipoproteins E
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
96Subventions
Organisme : NIA NIH HHS
ID : P30 AG066530
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054434
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG055770
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG076124
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG056518
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG067063
Pays : United States
Organisme : NIA NIH HHS
ID : R43 AG069552
Pays : United States
Informations de copyright
© 2023. The Author(s).
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