The clarifying lens of cryo-electron microscopy in immunoglobulin M biology.

Immunoglobulin M Cryoelectron Microscopy Biology
IgM complexes IgM immunobiology immunotherapy

Journal

Immunology and cell biology
ISSN: 1440-1711
Titre abrégé: Immunol Cell Biol
Pays: United States
ID NLM: 8706300

Informations de publication

Date de publication:
08 2023
Historique:
medline: 23 10 2023
pubmed: 24 5 2023
entrez: 24 5 2023
Statut: ppublish

Résumé

In this article, we discuss recent advances into the structural analyses of immunoglobulin M complexes, which are enabling comprehensive characterization of these enigmatic antibodies, to reveal central tenets of immunoglobulin M immunobiology and inform their immunotherapeutic use.

Identifiants

DOI: 10.1111/imcb.12656 PMID: 37221908
pubmed: 37221908
doi: 10.1111/imcb.12656
doi:

Substances chimiques

Immunoglobulin M 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

584-586

Informations de copyright

© 2023 the Australian and New Zealand Society for Immunology, Inc.

Références

Ehrenstein MR, Notley CA. The importance of natural IgM: scavenger, protector and regulator. Nat Rev Immunol 2010; 10: 778-786.
Czajkowsky DM, Shao Z. The human IgM pentamer is a mushroom-shaped molecule with a flexural bias. Proc Natl Acad Sci USA 2009; 106: 14960-14965.
Ma X, Zhu Y, Dong D, et al. Cryo-EM structures of two human B cell receptor isotypes. Science 2022; 377: 880-885.
Su Q, Chen M, Shi Y, et al. Cryo-EM structure of the human IgM B cell receptor. Science 2022; 377: 875-880.
Chen Q, Menon R, Calder LJ, Tolar P, Rosenthal PB. Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer. Nature Commun 2022; 13: e6314.
Kumar N, Arthur CP, Ciferri C, Matsumoto ML. Structure of the human secretory immunoglobulin M core. Structure 2021; 29: 564-571.e3.
Li Y, Wang G, Li N, et al. Structural insights into immunoglobulin M. Science 2020; 367: 1014-1017.
Hogarth PM, Pietersz GA. Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond. Nat Rev Drug Discov 2012; 11: 311-331.
Kubagawa H, Oka S, Kubagawa Y, et al. Identity of the elusive IgM Fc receptor (FcμR) in humans. J Exp Med 2009; 206: 2779-2793.
Li Y, Shen H, Zhang R, et al. Immunoglobulin M perception by FcμR. Nature 2023; 615: 907-912.

Auteurs

Michael T Rice (MT)

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

Benjamin S Gully (BS)

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline M › The clarifying lens of cryo-electron...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › The clarifying lens of cryo-electron...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › The clarifying lens of cryo-electron...