Role of perfusion index and plethysmography variability index for predicting outcomes in neonatal sepsis.
PI
PVI
microcirculation
neonates
sepsis
Journal
Acta paediatrica (Oslo, Norway : 1992)
ISSN: 1651-2227
Titre abrégé: Acta Paediatr
Pays: Norway
ID NLM: 9205968
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
revised:
20
05
2023
received:
03
02
2023
accepted:
23
05
2023
medline:
10
8
2023
pubmed:
24
5
2023
entrez:
24
5
2023
Statut:
ppublish
Résumé
(i) To compare perfusion index (PI) and plethysmography variability index (PVI) between neonates with proven or probable sepsis versus no-sepsis, (ii) to examine an association of PI and PVI with in-hospital mortality. We enrolled neonates with clinically presumed sepsis. Culture-proven or probable sepsis were categorised as 'cases' and no-sepsis as 'controls'. PI and PVI were recorded hourly for 120 h and averaged in 20-time epochs (0-6 h to 115-120 h). We analysed 148 neonates with sepsis (proven sepsis = 77, probable sepsis = 71) and 126 with no-sepsis. Neonates with proven/probable sepsis and no-sepsis had comparable PI and PVI values. Among 148 neonates with sepsis, 43 (29%) died. Non-survivors had significantly lower PI values than survivors (mean difference 0.21 [95% CI 0.14-0.29], p-value <0.001). PI had a significant but modest discriminative ability to identify non-survivors. However, PI did not independently predict mortality. Neonates with proven/probable sepsis and no-sepsis had comparable PI and PVI values in the first 120 h of sepsis. PI but not PVI values were significantly lower in non-survivors than survivors. PI did not independently predict in-hospital mortality. Due to modest discriminative ability, PI should be interpreted along with other vital signs to take clinical decisions.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1884-1891Subventions
Organisme : Indian Council of Medical Research, New Delhi
ID : RBMCH/Adhoc/11/2019-20
Informations de copyright
© 2023 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
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