Thiazole derivatives as dual inhibitors of deoxyribonuclease I and 5-lipoxygenase: A promising scaffold for the development of neuroprotective drugs.
5-Lipoxygenase
Deoxyribonuclease I
Dual inhibition
Molecular docking
Molecular dynamics
Thiazoles
Journal
Chemico-biological interactions
ISSN: 1872-7786
Titre abrégé: Chem Biol Interact
Pays: Ireland
ID NLM: 0227276
Informations de publication
Date de publication:
25 Aug 2023
25 Aug 2023
Historique:
received:
23
03
2023
revised:
02
05
2023
accepted:
15
05
2023
medline:
13
6
2023
pubmed:
25
5
2023
entrez:
24
5
2023
Statut:
ppublish
Résumé
A library of 43 thiazole derivatives, including 31 previously and 12 newly synthesized in the present study, was evaluated in vitro for their inhibitory properties against bovine pancreatic DNase I. Nine compounds (including three newly synthesized) inhibited the enzyme showing improved inhibitory properties compared to that of the reference crystal violet (IC
Identifiants
pubmed: 37224992
pii: S0009-2797(23)00209-0
doi: 10.1016/j.cbi.2023.110542
pii:
doi:
Substances chimiques
Thiazoles
0
Neuroprotective Agents
0
Arachidonate 5-Lipoxygenase
EC 1.13.11.34
VP1-001
0
Deoxyribonuclease I
EC 3.1.21.1
Lipoxygenase Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110542Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.