Thalidomide upper limb embryopathy - pathogenesis, past and present management and future considerations.
Thalidomide
cereblon
embryopathy
radial dysplasia
reversed shoulder
Journal
The Journal of hand surgery, European volume
ISSN: 2043-6289
Titre abrégé: J Hand Surg Eur Vol
Pays: England
ID NLM: 101315820
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
medline:
17
8
2023
pubmed:
25
5
2023
entrez:
25
5
2023
Statut:
ppublish
Résumé
This review article provides a comprehensive overview of thalidomide upper limb embryopathy including updates about its pathogenesis, a historical account of the management of the paediatric thalidomide patient, experience with management of the adult patient, as well as creating awareness about early onset age-related changes associated with limb differences. Despite its withdrawal from the market in November 1961, novel discoveries have meant thalidomide is licensed again and currently still in use to treat a variety of conditions, including inflammatory disorders and some cancers. Yet, if not used safely, thalidomide still has the potential to cause damage to the embryo. Recent work identifying thalidomide analogues that retain clinical benefits yet without the harmful effects are showing great promise. Understanding the problems thalidomide survivors face as they age can allow surgeons to support their unique healthcare issues and translate these principles of care to other congenital upper limb differences.
Identifiants
pubmed: 37226469
doi: 10.1177/17531934231177425
pmc: PMC10466950
doi:
Substances chimiques
Thalidomide
4Z8R6ORS6L
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
699-709Références
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