Coronary microcirculation and left ventricular diastolic function but not myocardial deformation indices are impaired early in patients with chronic kidney disease.
chronic kidney disease
coronary flow reserve
diastolic function
dipyridamole
myocardial strain
Journal
Echocardiography (Mount Kisco, N.Y.)
ISSN: 1540-8175
Titre abrégé: Echocardiography
Pays: United States
ID NLM: 8511187
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
revised:
20
04
2023
received:
28
12
2022
accepted:
03
05
2023
medline:
13
7
2023
pubmed:
25
5
2023
entrez:
25
5
2023
Statut:
ppublish
Résumé
To investigate abnormalities in myocardial strain and classic echocardiographic indices and coronary flow reserve (CFR), in younger versus older CKD patients. Sixty consecutive CKD patients (<60 years old n = 30, ≥60 years old n = 30) and 30 healthy controls (age- and gender-matched with younger CKD patients) were recruited. An echocardiographic assessment including myocardial strain indices (i.e. global longitudinal strain -GLS -, TWIST, UNTWIST rate) was performed at baseline and following dipyridamole administration in all participants. Younger CKD patients had higher E/e', left ventricular mass index and relative wall thickness and lower E' (p < .005 for all) compared to healthy controls. Older CKD patients had lower E/A and E' (p < .05 for both) compared to younger CKD patients; these differences did not remain significant after adjustment for age. CFR was higher in healthy controls compared to younger and older CKD patients (p < .05 for both) without a significant difference between CKD groups. There were no significant differences in GLS, TWIST or UNTWIST values among the three groups of patients. Dipyridamole-induced changes did not differ significantly among the three groups. Compared to healthy controls, impaired coronary microcirculation and left ventricular diastolic function, but not myocardial strain abnormalities, are found in young CKD patients and deteriorate with aging.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
600-607Informations de copyright
© 2023 Wiley Periodicals LLC.
Références
Lai AC, Bienstock SW, Sharma R, et al. A personalized approach to chronic kidney disease and cardiovascular disease: JACC review topic of the week. J Am Coll Cardiol. 2021;7:1470-1479.
Dohi K. Echocardiographic assessment of cardiac structure and function in chronic renal disease. J Echocardiogr. 2019;17:115-122.
Cherney DZI, Charbonnel B, Cosentino F, et al. Effects of ertugliflozin on kidney composite outcomes, renal function and albuminuria in patients with type 2 diabetes mellitus: an analysis from the randomised VERTIS CV trial. Diabetologia. 2021;64:1256-1267.
Gujral UP, Jagannathan R, He S, et al. Association between varying cut-points of intermediate hyperglycemia and risk of mortality, cardiovascular events and chronic kidney disease: a systematic review and meta-analysis. BMJ Open Diabetes Res Care. 2021:9.
Hubbard D, Colantonio LD, Rosenson RS, et al. Risk for recurrent cardiovascular disease events among patients with diabetes and chronic kidney disease. Cardiovasc Diabetol. 2021;20:58.
Lawson CA, Seidu S, Zaccardi F, et al. Outcome trends in people with heart failure, type 2 diabetes mellitus and chronic kidney disease in the UK over twenty years. E Clin Med. 2021;32:100739.
Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351:1296-1305.
Amann K, Tyralla K. Cardiovascular changes in chronic renal failure-pathogenesis and therapy. Clin Nephrol. 2002;58(1):S62-S72.
Jahn L, Kramann R, Marx N, Floege J, Becker M, Schlieper G. Speckle tracking echocardiography and all-cause and cardiovascular mortality risk in chronic kidney disease patients. Kidney Blood Press Res. 2019;44:690-703.
Liu YW, Su CT, Huang YY, et al. Left ventricular systolic strain in chronic kidney disease and hemodialysis patients. Am J Nephrol. 2011;33:84-90.
Potter E, Marwick TH. Assessment of left ventricular function by echocardiography: the case for routinely adding global longitudinal strain to ejection fraction. JACC Cardiovasc Imaging. 2018;11:260-274.
Marwick TH, Leano RL, Brown J, et al. Myocardial strain measurement with 2-dimensional speckle-tracking echocardiography: definition of normal range. JACC Cardiovasc Imaging. 2009;2:80-84.
Burns AT, La Gerche A, D'Hooge J, MacIsaac AI, Prior DL. Left ventricular strain and strain rate: characterization of the effect of load in human subjects. Eur J Echocardiogr. 2010;11:283-289.
Ravera M, Rosa GM, Fontanive P, et al. Impaired left ventricular global longitudinal strain among patients with chronic kidney disease and end-stage renal disease and renal transplant recipients. Cardiorenal Med. 2019;9:61-68.
Zhang T, Li J, Cao S. Prognostic value of left ventricular global longitudinal strain in chronic kidney disease patients: a systematic review and meta-analysis. Int Urol Nephrol. 2020;52:1747-1756.
Christensen J, Landler NE, Olsen FJ, et al. Left ventricular structure and function in patients with chronic kidney disease assessed by 3D echocardiography: the CPH-CKD ECHO study. Int J Cardiovasc Imaging. 2021.
Kovarova M, Zilinska Z, Pales J, et al. 3D echocardiography - a useful method for cardiovascular risk assessment in end-stage renal disease patients. Physiol Res. 2021;70:S109-S120.
Bezante GP, Viazzi F, Leoncini G, et al. Coronary flow reserve is impaired in hypertensive patients with subclinical renal damage. Am J Hypertens. 2009;22:191-196.
Picano E, Ostojic M, Varga A, et al. Combined low dose dipyridamole-dobutamine stress echocardiography to identify myocardial viability. J Am Coll Cardiol. 1996;27:1422-1428.
Hozumi T, Yoshida K, Akasaka T, et al. Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique. J Am Coll Cardiol. 1998;32:1251-1259.
Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150:604-612.
Lang RM, Badano LP, Mor-Avi V, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2015;16:233-270.
Lakkas L, Naka KK, Bechlioulis A, et al. The prognostic role of myocardial strain indices and dipyridamole stress test in renal transplantation patients. Echocardiography. 2020;37:62-70.
Vogel MW, Slusser JP, Hodge DO, Chen HH. The natural history of preclinical diastolic dysfunction: a population-based study. Circ Heart Fail. 2012;5:144-151.
Nakano S, Masuda K, Asanuma T, Nakatani S. The effect of chronic renal failure on cardiac function: an experimental study with a rat model. J Echocardiogr. 2016;14:156-162.
Playford D, Strange G, Celermajer DS, et al. Diastolic dysfunction and mortality in 436 360 men and women: the National Echo Database Australia (NEDA). Eur Heart J Cardiovasc Imaging. 2021;22:505-515.
Sharma R, Pellerin D, Gaze DC, et al. Mitral peak Doppler E-wave to peak mitral annulus velocity ratio is an accurate estimate of left ventricular filling pressure and predicts mortality in end-stage renal disease. J Am Soc Echocardiogr. 2006;19:266-273.
Kadappu KK, Abhayaratna K, Boyd A, et al. Independent echocardiographic markers of cardiovascular involvement in chronic kidney disease: the value of left atrial function and volume. J Am Soc Echocardiogr. 2016;29:359-367.
Tripepi G, Benedetto FA, Mallamaci F, Tripepi R, Malatino L, Zoccali C. Left atrial volume in end-stage renal disease: a prospective cohort study. J Hypertens. 2006;24:1173-1180.
Tripepi G, Mattace-Raso F, Mallamaci F, et al. Biomarkers of left atrial volume: a longitudinal study in patients with end stage renal disease. Hypertension. 2009;54:818-824.
Matsushita K, Kwak L, Sang Y, et al. Kidney disease measures and left ventricular structure and function: the atherosclerosis risk in communities study. J Am Heart Assoc. 2017:6.
Park M, Hsu CY, Li Y, et al. Associations between kidney function and subclinical cardiac abnormalities in CKD. J Am Soc Nephrol. 2012;23:1725-1734.
Pluta A, Strozecki P, Krintus M, Odrowaz-Sypniewska G, Manitius J. Left ventricular remodeling and arterial remodeling in patients with chronic kidney disease stage 1-3. Ren Fail. 2015;37:1105-1110.
Dubin RF, Deo R, Bansal N, et al. Associations of conventional echocardiographic measures with incident heart failure and mortality: the chronic renal insufficiency cohort. Clin J Am Soc Nephrol. 2017;12:60-68.
Galderisi M. Epicardial coronary vessels and coronary microcirculation in pressure overload hypertrophy: a complex interaction. Am J Hypertens. 2007;20:285-286.
Pirat B, Bozbas H, Simsek V, et al. Impaired coronary flow reserve in patients with metabolic syndrome. Atherosclerosis. 2008;201:112-116.
Karayannis G, Giamouzis G, Alexandridis E, et al. Prevalence of impaired coronary flow reserve and its association with left ventricular diastolic function in asymptomatic individuals with major cardiovascular risk factors. Eur J Cardiovasc Prev Rehabil. 2011;18:326-333.
Gkirdis I, Naka KK, Lakkas L, et al. Coronary microcirculation and left ventricular diastolic function: comparison between patients on hemodialysis and peritoneal dialysis. J Echocardiogr. 2021;19:103-112.
Evangelou D, Bechlioulis A, Tzeltzes G, et al. Myocardial strain indices and coronary flow reserve are only mildly affected in healthy hypertensive patients. Int J Cardiovasc Imaging. 2021;37:69-79.
Chade AR, Brosh D, Higano ST, Lennon RJ, Lerman LO, Lerman A. Mild renal insufficiency is associated with reduced coronary flow in patients with non-obstructive coronary artery disease. Kidney Int. 2006;69:266-271.
Kashioulis P, Guron CW, Svensson MK, Hammarsten O, Saeed A, Guron G. Patients with moderate chronic kidney disease without heart disease have reduced coronary flow velocity reserve. ESC Heart Fail. 2020;7:2797-2806.
Bajaj NS, Singh A, Zhou W, et al. Coronary microvascular dysfunction, left ventricular remodeling, and clinical outcomes in patients with chronic kidney impairment. Circulation. 2020;141:21-33.
Papamichail N, Bechlioulis A, Lakkas L, et al. Impaired coronary microcirculation is associated with left ventricular diastolic dysfunction in end-stage chronic kidney disease patients. Echocardiography. 2020;37:536-545.
Nakanishi K, Fukuda S, Shimada K, et al. Prognostic value of coronary flow reserve on long-term cardiovascular outcomes in patients with chronic kidney disease. Am J Cardiol. 2013;112:928-932.
Charytan DM, Skali H, Shah NR, et al. Coronary flow reserve is predictive of the risk of cardiovascular death regardless of chronic kidney disease stage. Kidney Int. 2018;93:501-509.
Panoulas VF, Sulemane S, Konstantinou K, et al. Early detection of subclinical left ventricular myocardial dysfunction in patients with chronic kidney disease. Eur Heart J Cardiovasc Imaging. 2015;16:539-548.
Krishnasamy R, Isbel NM, Hawley CM, et al. Left ventricular global longitudinal strain (GLS) is a superior predictor of all-cause and cardiovascular mortality when compared to ejection fraction in advanced chronic kidney disease. PLoS One. 2015;10:e0127044.
Cognet T, Vervueren PL, Dercl. New concept of myocardial longitudinal strain reserve assessed by a dipyridamole infusion using 2D-strain echocardiography: the impact of diabetes and age, and the prognostic value. Cardiovasc Diabetol. 2013;12:84.