Resveratrol as a circadian clock modulator: mechanisms of action and therapeutic applications.
Biological clock
Chrononutrition
Circadian rhythm
Nutraceuticals
Resveratrol
Sirtuin 1
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
07
03
2023
accepted:
10
05
2023
medline:
26
6
2023
pubmed:
26
5
2023
entrez:
25
5
2023
Statut:
ppublish
Résumé
In the past decades, resveratrol has gained increasing attention due to its versatile and beneficial properties. This natural polyphenol, commonly present in the human diet, has been shown to induce SIRT1 and to modulate the circadian rhythm at the cellular and organismal levels. The circadian clock is a system regulating behavior and function of the human body, thus playing a crucial role in health maintenance. It is primarily entrained by light-dark cycles; however, other factors such as feeding-fasting, oxygen and temperature cycles play a significant role in its regulation. Chronic circadian misalignment can lead to numerous pathologies, including metabolic disorders, age-related diseases or cancer. Therefore, the use of resveratrol may be a valuable preventive and/or therapeutic strategy for these pathologies. This review summarizes studies that evaluated the modulatory effect of resveratrol on circadian oscillators by focusing on the potential and limitations of resveratrol in biological clock-related disorders.
Identifiants
pubmed: 37231216
doi: 10.1007/s11033-023-08513-2
pii: 10.1007/s11033-023-08513-2
pmc: PMC10289927
doi:
Substances chimiques
Resveratrol
Q369O8926L
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
6159-6170Informations de copyright
© 2023. The Author(s).
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