Oxidative Cyclization at
anti-mycobacterial agent
demethyl(oxy)aaptamine
hypervalent iodine reagent
oxidative cyclization
total synthesis
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
19 May 2023
19 May 2023
Historique:
received:
28
04
2023
revised:
13
05
2023
accepted:
17
05
2023
medline:
29
5
2023
pubmed:
26
5
2023
entrez:
26
5
2023
Statut:
epublish
Résumé
A shorter synthesis of the demethyl(oxy)aaptamine skeleton was developed via oxidative intramolecular cyclization of 1-(2-azidoethyl)-6-methoxyisoquinolin-7-ol followed by dehydrogenation with a hypervalent iodine reagent. This is the first example of oxidative cyclization at the
Identifiants
pubmed: 37233505
pii: md21050311
doi: 10.3390/md21050311
pmc: PMC10221624
pii:
doi:
Substances chimiques
3-(phenethylamino)demethyl(oxy)aaptamine
0
aaptamine
FGW9D01COE
Phenol
339NCG44TV
Phenols
0
Naphthyridines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 18K05363
Organisme : Japan Society for the Promotion of Science
ID : 22K05339
Organisme : Research Promotion Program for Acquiring KAKENHI from Ritsumeikan University
ID : B21-0051
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