Selenium vitaminology: The connection between selenium, vitamin C, vitamin E, and ergothioneine.
Journal
Current opinion in chemical biology
ISSN: 1879-0402
Titre abrégé: Curr Opin Chem Biol
Pays: England
ID NLM: 9811312
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
20
03
2023
revised:
25
04
2023
accepted:
26
04
2023
pmc-release:
01
08
2024
medline:
7
8
2023
pubmed:
27
5
2023
entrez:
26
5
2023
Statut:
ppublish
Résumé
Selenium is connected to three small molecule antioxidant compounds, ascorbate, α-tocopherol, and ergothioneine. Ascorbate and α-tocopherol are true vitamins, while ergothioneine is a "vitamin-like" compound. Here we review how selenium is connected to all three. Selenium and vitamin E work together as a team to prevent lipid peroxidation. Vitamin E quenches lipid hydroperoxyl radicals and the resulting lipid hydroperoxide is then converted to the lipid alcohol by selenocysteine-containing glutathione peroxidase. Ascorbate reduces the resulting α-tocopheroxyl radical in this reaction back to α-tocopherol with concomitant production of the ascorbyl radical. The ascorbyl radical can be reduced back to ascorbate by selenocysteine-containing thioredoxin reductase. Ergothioneine and ascorbate are both water soluble, small molecule reductants that can reduce free radicals and redox-active metals. Thioredoxin reductase can reduce oxidized forms of ergothioneine. While the biological significance of this is not yet realized, this discovery underscores the centrality of selenium to all three antioxidants.
Identifiants
pubmed: 37236134
pii: S1367-5931(23)00066-2
doi: 10.1016/j.cbpa.2023.102328
pmc: PMC10524500
mid: NIHMS1897143
pii:
doi:
Substances chimiques
Ascorbic Acid
PQ6CK8PD0R
Selenium
H6241UJ22B
Ergothioneine
BDZ3DQM98W
semidehydroascorbic acid
6730-29-6
alpha-Tocopherol
H4N855PNZ1
Selenocysteine
0CH9049VIS
Thioredoxin-Disulfide Reductase
EC 1.8.1.9
Vitamin E
1406-18-4
Antioxidants
0
Vitamins
0
Free Radicals
0
Lipid Peroxides
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
102328Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL141146
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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