A genome-wide association study of antidepressant-induced mania.

Humans Mania / drug therapy Genome-Wide Association Study Hypothalamo-Hypophyseal System Pituitary-Adrenal System Antidepressive Agents / therapeutic use
Antidepressant-induced mania Bipolar disorder Depression Genome-wide association study Pharmacogenetics

Journal

Progress in neuro-psychopharmacology & biological psychiatry
ISSN: 1878-4216
Titre abrégé: Prog Neuropsychopharmacol Biol Psychiatry
Pays: England
ID NLM: 8211617

Informations de publication

Date de publication:
20 12 2023
Historique:
received: 25 01 2023
revised: 20 05 2023
accepted: 21 05 2023
medline: 7 9 2023
pubmed: 27 5 2023
entrez: 26 5 2023
Statut: ppublish

Résumé

Antidepressant-induced mania (AIM) is a side effect of antidepressant treatment that is characterized by mania or hypomania after the start of medication. It is likely polygenic, but its genetic component remains largely unexplored. We aim to conduct the first genome-wide association study of AIM in 814 bipolar disorder patients of European ancestry. We report no significant findings from our single-marker or gene-based analyses. Our polygenic risk score analyses also did not yield significant results with bipolar disorder, antidepressant response, or lithium response. Our suggestive findings on the hypothalamic-pituitary-adrenal axis and the opioid system in AIM require independent replications.

Identifiants

DOI: 10.1016/j.pnpbp.2023.110800 PMID: 37236419
pubmed: 37236419
pii: S0278-5846(23)00086-6
doi: 10.1016/j.pnpbp.2023.110800
pii:
doi:

Substances chimiques

Antidepressive Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

110800

Informations de copyright

Copyright © 2023. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of Competing Interest CCZ, AKT, and JLK hold patents for genetic markers related to psychotropic medication outcomes. JLK is a member of the Scientific Advisory Board of Myriad Neuroscience. The other authors reported no conflicts of interest related to this study.

Auteurs

Clement C Zai (CC)

Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; Department of Psychiatry, University of Toronto, Canada; Institute of Medical Science, University of Toronto, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Canada; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, United States of America. Electronic address: clement.zai@camh.ca.

Alessio Squassina (A)

Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Cagliari, Italy.

Arun K Tiwari (AK)

Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; Department of Psychiatry, University of Toronto, Canada.

Claudia Pisanu (C)

Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Cagliari, Italy.

Marco Pinna (M)

Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09124 Cagliari, Italy; Lucio Bini Mood Disorders Center, Cagliari, Italy.

Federica Pinna (F)

Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09124 Cagliari, Italy; Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09124 Cagliari, Italy.

Anna Meloni (A)

Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, 09042 Cagliari, Italy.

Pasquale Paribello (P)

Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09124 Cagliari, Italy; Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09124 Cagliari, Italy.

Bernardo Carpiniello (B)

Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09124 Cagliari, Italy; Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09124 Cagliari, Italy.

Leonardo Tondo (L)

Lucio Bini Mood Disorders Center, Cagliari, Italy; McLean Hospital-Harvard Medical School, Boston, USA.

Mark A Frye (MA)

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.

Joanna M Biernacka (JM)

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

Brandon J Coombes (BJ)

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.

James L Kennedy (JL)

Tanenbaum Centre for Pharmacogenetics, Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; Department of Psychiatry, University of Toronto, Canada; Institute of Medical Science, University of Toronto, Canada.

Mirko Manchia (M)

Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, 09124 Cagliari, Italy; Unit of Clinical Psychiatry, University Hospital Agency of Cagliari, 09124 Cagliari, Italy; Department of Pharmacology, Dalhousie University, Halifax, NS B3H 4R2, Canada; McLean Hospital-Harvard Medical School, Boston, USA.

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Classifications MeSH

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questionsmedicales.fr › Comportement et mécanismes comportementaux › Manifestations neurocomportementales › Manie › A genome-wide association study of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › A genome-wide association study of...
questionsmedicales.fr › Système nerveux › Système neuroendocrinien › Axe hypothalamohypophysaire › A genome-wide association study of...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Axe hypophyso-surrénalien › A genome-wide association study of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Antidépresseurs › A genome-wide association study of...