Four new eudesmane-type and one new eremophilane-type sesquiterpenes from the whole plant of Carpesium abrotanoides L.
Carpesium abrotanoides L.
Eremophilane
Eudesmane
Inhibitory activity
SARS-CoV-2 main protease
Sesquiterpene
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
09
03
2023
revised:
18
05
2023
accepted:
20
05
2023
medline:
21
8
2023
pubmed:
27
5
2023
entrez:
26
5
2023
Statut:
ppublish
Résumé
The extract of the whole plant of Carpesium abrotanoides L. yielded five new sesquiterpenes including four eudesmanes (1-4) and one eremophilane (5). The new compounds were characterized by spectroscopic analysis especially 1D and 2D NMR spectroscopy and HRESIMS data. Structurally, both compounds 1 and 2 were sesquiterpene epoxides and 2 owned an epoxy group at C-4/C-15 position to form a spiro skeleton. Compounds 4 and 5 were two sesquiterpenes without lactones and 5 possessed a carboxy group in the molecule. Additionally, all the isolated compounds were preliminarily evaluated for the inhibitory activity against SARS-CoV-2 main protease. As a result, compound 2 showed moderate activity with an IC
Identifiants
pubmed: 37236512
pii: S0367-326X(23)00123-5
doi: 10.1016/j.fitote.2023.105548
pii:
doi:
Substances chimiques
Polycyclic Sesquiterpenes
0
Sesquiterpenes
0
eudesmane
473-11-0
Sesquiterpenes, Eudesmane
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105548Informations de copyright
Copyright © 2023. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no conflicts of interest.