The Controversial Roles of Areca Nut: Medicine or Toxin?
areca nut
component
pharmacological activity
toxicological effect
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 May 2023
19 May 2023
Historique:
received:
14
04
2023
revised:
12
05
2023
accepted:
17
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Areca nut (AN) is used for traditional herbal medicine and social activities in several countries. It was used as early as about A.D. 25-220 as a remedy. Traditionally, AN was applied for several medicinal functions. However, it was also reported to have toxicological effects. In this review article, we updated recent trends of research in addition to acquire new knowledge about AN. First, the history of AN usage from ancient years was described. Then, the chemical components of AN and their biological functions was compared; arecoline is an especially important compound in AN. AN extract has different effects caused by different components. Thus, the dual effects of AN with pharmacological and toxicological effects were summarized. Finally, we described perspectives, trends and challenges of AN. It will provide the insight of removing or modifying the toxic compounds of AN extractions for enhancing their pharmacological activity to treat several diseases in future applications.
Identifiants
pubmed: 37240342
pii: ijms24108996
doi: 10.3390/ijms24108996
pmc: PMC10219234
pii:
doi:
Substances chimiques
Plant Extracts
0
Arecoline
4ALN5933BH
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science and Technology Council
ID : 108-2314-B-037-075
Organisme : National Science and Technology Council
ID : 109-2320-B-037-015-MY3
Organisme : Kaohsiung Medical University Research Foundation
ID : KMU-M103001
Organisme : Kaohsiung Medical University Research Foundation
ID : KMU-M104003
Organisme : Kaohsiung Medical University Research Foundation
ID : KMU-TP104PR16
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