Carrier-Mediated Process of Putrescine Elimination at the Rat Blood-Retinal Barrier.
blood–retinal barrier
choline transporter-like protein
polyamine
putrescine
transport
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 May 2023
19 May 2023
Historique:
received:
27
04
2023
revised:
15
05
2023
accepted:
16
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Putrescine is a bioactive polyamine. Its retinal concentration is strictly controlled to maintain a healthy sense of vision. The present study investigated putrescine transport at the blood-retinal barrier (BRB) to gain a better understanding of the mechanisms of putrescine regulation in the retina. Our microdialysis study showed that the elimination rate constant during the terminal phase was significantly greater (1.90-fold) than that of [
Identifiants
pubmed: 37240348
pii: ijms24109003
doi: 10.3390/ijms24109003
pmc: PMC10219508
pii:
doi:
Substances chimiques
Putrescine
V10TVZ52E4
Polyamines
0
Mannitol
3OWL53L36A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 20H03403
Organisme : Japan Society for the Promotion of Science
ID : 17K08409
Organisme : Japan Society for the Promotion of Science
ID : 23K14381
Organisme : Tamura Science and Technology Foundation
ID : N/A
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