Follicle-Stimulating Hormone Biological Products: Does Potency Predict Clinical Efficacy?
follicle-stimulating hormone
glycoform
gonadotropin
heterogeneity
potency
reproduction
sialylation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 May 2023
19 May 2023
Historique:
received:
24
03
2023
revised:
12
05
2023
accepted:
15
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
Follicle-stimulating hormone (FSH), together with luteinizing hormone (LH) and human chorionic gonadotropin (hCG), plays a fundamental role in human reproduction. The discovery of FSH and other gonadotropins was a defining moment in our understanding of reproduction and led to the development of many treatments for infertility. In this regard, exogenous FSH has been used to treat infertility in women for decades. Today, several recombinant and highly purified urinary forms of FSH are used in medically assisted reproduction (MAR). However, differences in the macro- and micro-heterogeneity of FSH result in a variety of FSH glycoforms, with glycoform composition determining the bioactivity (or potency), pharmacokinetic/pharmacodynamic (PK/PD) profiles, and clinical efficacy of the different forms of FSH. This review illustrates how the structural heterogeneity of FSH glycoforms affects the biological activity of human FSH products, and why potency does not predict effects in humans in terms of PK, PD, and clinical response.
Identifiants
pubmed: 37240364
pii: ijms24109020
doi: 10.3390/ijms24109020
pmc: PMC10218858
pii:
doi:
Substances chimiques
Follicle Stimulating Hormone
9002-68-0
Follicle Stimulating Hormone, Human
0
Biological Products
0
Chorionic Gonadotropin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Merck (CrossRef Funder ID: 10.13039/100009945)
ID : N/A
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