The Many Ways to Deal with STING.
IFN
STING
antiviral response
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 May 2023
20 May 2023
Historique:
received:
24
04
2023
revised:
15
05
2023
accepted:
16
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
The stimulator of interferon genes (STING) is an adaptor protein involved in the activation of IFN-β and many other genes associated with the immune response activation in vertebrates. STING induction has gained attention from different angles such as the potential to trigger an early immune response against different signs of infection and cell damage, or to be used as an adjuvant in cancer immune treatments. Pharmacological control of aberrant STING activation can be used to mitigate the pathology of some autoimmune diseases. The STING structure has a well-defined ligand binding site that can harbor natural ligands such as specific purine cyclic di-nucleotides (CDN). In addition to a canonical stimulation by CDNs, other non-canonical stimuli have also been described, whose exact mechanism has not been well defined. Understanding the molecular insights underlying the activation of STING is important to realize the different angles that need to be considered when designing new STING-binding molecules as therapeutic drugs since STING acts as a versatile platform for immune modulators. This review analyzes the different determinants of STING regulation from the structural, molecular, and cell biology points of view.
Identifiants
pubmed: 37240378
pii: ijms24109032
doi: 10.3390/ijms24109032
pmc: PMC10219357
pii:
doi:
Substances chimiques
Nucleotides, Cyclic
0
Adjuvants, Immunologic
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
PLoS Pathog. 2018 Nov 2;14(11):e1007435
pubmed: 30388174
Viruses. 2019 Feb 01;11(2):
pubmed: 30717138
J Hepatol. 2013 Jul;59(1):52-8
pubmed: 23542348
J Exp Med. 2020 Jul 6;217(7):
pubmed: 32383759
J Virol. 2020 Apr 16;94(9):
pubmed: 32075929
Cell. 2020 Aug 20;182(4):1009-1026.e29
pubmed: 32730809
Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):8947-52
pubmed: 26150511
EMBO J. 2020 Nov 16;39(22):e104106
pubmed: 32926474
Clin Cancer Res. 2022 Feb 15;28(4):677-688
pubmed: 34716197
Front Pharmacol. 2021 Nov 15;12:779425
pubmed: 34867409
PLoS Pathog. 2015 Dec 08;11(12):e1005324
pubmed: 26646986
Cell Immunol. 2012 Jul-Aug;278(1-2):113-9
pubmed: 23121983
J Med Chem. 2022 Nov 24;65(22):15048-15065
pubmed: 36069713
Cell. 2019 Jul 11;178(2):290-301.e10
pubmed: 31230712
EMBO J. 2013 May 15;32(10):1440-50
pubmed: 23604073
Nat Immunol. 2019 Feb;20(2):152-162
pubmed: 30643259
J Med Chem. 2020 Apr 23;63(8):3785-3816
pubmed: 31820978
J Clin Invest. 2014 Dec;124(12):5516-20
pubmed: 25401470
Nat Commun. 2016 Jun 21;7:11932
pubmed: 27324217
ChemMedChem. 2018 Oct 8;13(19):2057-2064
pubmed: 30079976
Front Immunol. 2020 Apr 28;11:615
pubmed: 32411126
Immunity. 2018 Apr 17;48(4):688-701.e7
pubmed: 29625897
Sci Rep. 2016 Feb 26;6:22142
pubmed: 26917047
Cell Res. 2016 Dec;26(12):1302-1319
pubmed: 27801882
Nature. 2022 Mar;603(7901):439-444
pubmed: 35296845
PLoS Pathog. 2019 Apr 3;15(4):e1007680
pubmed: 30943264
Nat Immunol. 2012 Jun 17;13(8):737-43
pubmed: 22706339
Fac Rev. 2021 Jun 08;10:54
pubmed: 34195693
Cell Mol Immunol. 2019 Mar;16(3):236-241
pubmed: 30796349
Acta Pharm Sin B. 2020 Dec;10(12):2272-2298
pubmed: 33354501
Nat Commun. 2022 Jan 10;13(1):26
pubmed: 35013136
Cell Death Differ. 2021 Jan;28(1):139-155
pubmed: 32678307
Drug Discov Today. 2020 Jan;25(1):230-237
pubmed: 31758915
Nat Rev Immunol. 2021 Sep;21(9):548-569
pubmed: 33833439
Sci Rep. 2022 May 20;12(1):8579
pubmed: 35595822
Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):
pubmed: 34099558
Nat Commun. 2016 Feb 19;7:10680
pubmed: 26893169
J Gen Virol. 2013 Jul;94(Pt 7):1554-1567
pubmed: 23596270
Nature. 2021 Mar;591(7849):275-280
pubmed: 33442058
Nature. 2020 Oct;586(7829):429-433
pubmed: 32877915
Angew Chem Int Ed Engl. 2021 Apr 26;60(18):10172-10178
pubmed: 33616279
Cell Host Microbe. 2015 Aug 12;18(2):157-68
pubmed: 26235147
Science. 2020 Aug 14;369(6505):823-828
pubmed: 32792394
Nature. 2022 Aug;608(7924):803-807
pubmed: 35859168
PLoS Pathog. 2015 Jun 26;11(6):e1005012
pubmed: 26114947
Nat Commun. 2017 Feb 10;8:14391
pubmed: 28186168
Science. 2020 Aug 21;369(6506):993-999
pubmed: 32820126
PLoS Pathog. 2012;8(10):e1002934
pubmed: 23055924
Nat Commun. 2017 Oct 16;8(1):945
pubmed: 29038422
EMBO Rep. 2020 Dec 3;21(12):e51345
pubmed: 33155371
Cells. 2022 Sep 28;11(19):
pubmed: 36231006
J Virol. 2016 Sep 29;90(20):9406-19
pubmed: 27512060
Nature. 2018 Dec;564(7736):439-443
pubmed: 30405246
J Virol. 2015 Feb;89(4):2287-300
pubmed: 25505063
Nat Immunol. 2016 Sep;17(9):1057-66
pubmed: 27428826
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20842-6
pubmed: 19926846
J Biomol Struct Dyn. 1989 Feb;6(4):801-14
pubmed: 2619941
Virus Res. 2017 Mar 15;232:13-21
pubmed: 28119118
Immunity. 2013 May 23;38(5):870-80
pubmed: 23706668
ACS Chem Biol. 2013 Jul 19;8(7):1396-401
pubmed: 23683494
N Engl J Med. 2014 Aug 7;371(6):507-518
pubmed: 25029335
Nat Commun. 2017 May 23;8:15534
pubmed: 28534493
Adv Drug Deliv Rev. 2021 Dec;179:114020
pubmed: 34756942
Nature. 2020 Nov;587(7835):668-672
pubmed: 32911482
Eur J Med Chem. 2022 Dec 15;244:114814
pubmed: 36228412
Sci Rep. 2012;2:347
pubmed: 22470840
Nat Commun. 2020 Dec 3;11(1):6182
pubmed: 33273464
Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16544-9
pubmed: 24052526
Microb Biotechnol. 2012 Mar;5(2):168-76
pubmed: 21958423
FEMS Microbiol Rev. 2016 Sep;40(5):753-73
pubmed: 27354347
PLoS Genet. 2018 Apr 16;14(4):e1007342
pubmed: 29659565
Front Immunol. 2021 Nov 18;12:771744
pubmed: 34868032
J Bacteriol. 2022 Feb 15;204(2):e0043321
pubmed: 34606374
Cold Spring Harb Perspect Biol. 2011 Jun 01;3(6):
pubmed: 21441595
EMBO Rep. 2022 Jun 7;23(6):e53932
pubmed: 35403787
J Clin Invest. 2016 Jul 1;126(7):2404-11
pubmed: 27367184
Cell Rep. 2020 Oct 20;33(3):108297
pubmed: 33086059
Cell. 2013 Aug 15;154(4):748-62
pubmed: 23910378
Immunity. 2009 Mar 20;30(3):397-407
pubmed: 19285439
PLoS Pathog. 2015 Mar 27;11(3):e1004783
pubmed: 25815785
Nat Struct Mol Biol. 2012 Jun 24;19(7):722-4
pubmed: 22728658
Nat Commun. 2020 Nov 26;11(1):6000
pubmed: 33243993
Nat Rev Immunol. 2015 Dec;15(12):760-70
pubmed: 26603901
Sci Rep. 2017 Jun 15;7(1):3594
pubmed: 28620207
Mol Cell. 2012 Jun 29;46(6):735-45
pubmed: 22705373
Signal Transduct Target Ther. 2021 Mar 15;6(1):123
pubmed: 33723219
Genes Immun. 2019 Jan;20(1):82-89
pubmed: 29728611
PLoS Pathog. 2018 Aug 16;14(8):e1007148
pubmed: 30114241
Immunity. 2014 Dec 18;41(6):919-33
pubmed: 25526307
Cytokine Growth Factor Rev. 2020 Oct;55:1-14
pubmed: 32563552
EMBO Rep. 2017 Oct;18(10):1707-1715
pubmed: 28801534
Protein Cell. 2014 May;5(5):369-81
pubmed: 24622840
Nature. 2019 Mar;567(7747):262-266
pubmed: 30842662
JCI Insight. 2021 Aug 9;6(15):
pubmed: 34156982
Nature. 2019 Feb;566(7743):259-263
pubmed: 30728498
Crit Rev Microbiol. 2015 Jun;41(2):150-64
pubmed: 25168431
Cell Rep. 2017 Dec 12;21(11):3234-3242
pubmed: 29241549
J Exp Med. 2017 Apr 3;214(4):991-1010
pubmed: 28254948
J Immunol. 2018 Nov 1;201(9):2641-2653
pubmed: 30282750
J Biol Chem. 2012 Aug 17;287(34):28646-55
pubmed: 22745133
Cell Rep. 2014 Sep 25;8(6):1668-1676
pubmed: 25199835
J Adv Res. 2023 Feb;44:119-133
pubmed: 35636721
Signal Transduct Target Ther. 2021 Apr 30;6(1):170
pubmed: 33927185
Nature. 2022 Apr;604(7906):557-562
pubmed: 35388221
J Biol Chem. 2013 Apr 12;288(15):10715-21
pubmed: 23443666
J Allergy Clin Immunol. 2017 Aug;140(2):543-552.e5
pubmed: 28087229
Trends Parasitol. 2020 Sep;36(9):773-784
pubmed: 32736985
J Med Chem. 2021 May 27;64(10):6902-6923
pubmed: 34000802
Cancer Immunol Res. 2017 Jun;5(6):468-479
pubmed: 28483787
Curr Opin Struct Biol. 2019 Dec;59:178-187
pubmed: 31593902
Mol Ther. 2022 Mar 2;30(3):1006-1017
pubmed: 35121107
J Immunol. 2013 May 15;190(10):5216-25
pubmed: 23585680
Curr Opin Virol. 2022 Apr;53:101206
pubmed: 35180533
Sci Immunol. 2017 May 5;2(11):
pubmed: 28763789
J Allergy Clin Immunol. 2022 Mar;149(3):819-832
pubmed: 34893352
Immunity. 2021 May 11;54(5):962-975.e8
pubmed: 33857420
Cell Rep. 2018 Dec 18;25(12):3405-3421.e7
pubmed: 30566866
Cell. 2013 Oct 24;155(3):688-98
pubmed: 24119841
Sci Signal. 2022 Apr 12;15(729):eabg8744
pubmed: 35412852
Nature. 2009 Oct 8;461(7265):788-92
pubmed: 19776740
PLoS Pathog. 2020 Mar 3;16(3):e1008387
pubmed: 32126128
Oncoimmunology. 2020 Jun 16;9(1):1777624
pubmed: 32934881
mBio. 2020 Aug 4;11(4):
pubmed: 32753499
Science. 2013 Feb 15;339(6121):786-91
pubmed: 23258413
Sci Rep. 2022 Aug 24;12(1):14464
pubmed: 36002507
EMBO Rep. 2018 Aug;19(8):
pubmed: 29880709
Nat Rev Microbiol. 2018 Jun;16(6):330
pubmed: 29666420
Nat Commun. 2018 Jun 13;9(1):2329
pubmed: 29899553
Immunohorizons. 2018 Dec 11;2(11):363-376
pubmed: 31026807
Sci Adv. 2020 Nov 20;6(47):
pubmed: 33219031
Science. 2013 Feb 15;339(6121):826-30
pubmed: 23258412
Molecules. 2021 Jul 12;26(14):
pubmed: 34299503
PLoS One. 2013 Oct 21;8(10):e77846
pubmed: 24204993
Nat Chem Biol. 2014 Dec;10(12):1043-8
pubmed: 25344812
Immunity. 2013 Sep 19;39(3):482-95
pubmed: 23993650
J Med Chem. 2022 Feb 24;65(4):3518-3538
pubmed: 35108011
Annu Rev Immunol. 2008;26:535-84
pubmed: 18303999
PLoS Pathog. 2019 Aug 15;15(8):e1007899
pubmed: 31415679
ChemMedChem. 2021 Jun 7;16(11):1740-1743
pubmed: 33522135
J Immunol. 2019 Apr 15;202(8):2397-2406
pubmed: 30814308
Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15408-13
pubmed: 26607445
Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6310-E6318
pubmed: 29915078
Front Immunol. 2020 Jan 31;10:3147
pubmed: 32082307
PLoS Pathog. 2018 Jan 3;14(1):e1006829
pubmed: 29298342
PLoS Pathog. 2020 Jan 22;16(1):e1008178
pubmed: 31968013
Mol Cell. 2013 Jul 25;51(2):135-9
pubmed: 23870141
Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2058-E2067
pubmed: 29440426
Immunity. 2012 Jun 29;36(6):1073-86
pubmed: 22579474
Front Cell Infect Microbiol. 2017 Jun 21;7:273
pubmed: 28680857
J Immunol. 2017 Jul 15;199(2):397-402
pubmed: 28615418
J Virol. 2018 Sep 26;92(20):
pubmed: 30045990
J Virol. 2020 Jun 1;94(12):
pubmed: 32238587
Signal Transduct Target Ther. 2021 Jun 2;6(1):208
pubmed: 34078874
Front Immunol. 2019 Dec 05;10:2770
pubmed: 31866997
Microbiol Spectr. 2015 Apr;3(2):MB-0003-2014
pubmed: 26104694
EMBO J. 2016 Jul 1;35(13):1385-99
pubmed: 27234299
PLoS Pathog. 2020 Oct 15;16(10):e1008999
pubmed: 33057424
Nat Commun. 2020 Nov 2;11(1):5536
pubmed: 33139700
J Biol Chem. 2006 Nov 24;281(47):35686-98
pubmed: 16887803
Br J Cancer. 2013 Apr 2;108(6):1306-15
pubmed: 23481185
Cell Rep. 2020 Apr 7;31(1):107492
pubmed: 32268090
Nature. 2019 Mar;567(7748):389-393
pubmed: 30842659
Nature. 2019 Oct;574(7780):691-695
pubmed: 31533127
Science. 2020 Aug 21;369(6506):
pubmed: 32820094
Front Immunol. 2022 May 06;13:888147
pubmed: 35603197
Cell Discov. 2022 Dec 13;8(1):133
pubmed: 36513640
PLoS Pathog. 2014 Sep 25;10(9):e1004358
pubmed: 25254379
Mol Cell. 2018 Sep 6;71(5):745-760.e5
pubmed: 30193098
Mol Cell. 2015 Sep 17;59(6):891-903
pubmed: 26300263
Mol Cell. 2013 Jul 25;51(2):226-35
pubmed: 23747010
EMBO J. 2018 Apr 13;37(8):
pubmed: 29496741
Hepatology. 2013 Jan;57(1):46-58
pubmed: 22911572
Nature. 2018 Jul;559(7713):269-273
pubmed: 29973723
Science. 2013 Sep 20;341(6152):1390-4
pubmed: 23989956
J Med Chem. 2022 May 12;65(9):6593-6611
pubmed: 35452223
ACS Med Chem Lett. 2018 Dec 06;10(1):92-97
pubmed: 30655953
Elife. 2020 Nov 16;9:
pubmed: 33191912
J Immunol. 2019 Dec 15;203(12):3374-3385
pubmed: 31704883
Annu Rev Virol. 2018 Sep 29;5(1):385-405
pubmed: 29949725
Cell Mol Immunol. 2021 Aug;18(8):1945-1955
pubmed: 32879469
PLoS One. 2020 Sep 10;15(9):e0237743
pubmed: 32911484
Nature. 2008 Oct 2;455(7213):674-8
pubmed: 18724357
Nat Immunol. 2010 Jun;11(6):487-94
pubmed: 20453844
Nature. 2011 Sep 25;478(7370):515-8
pubmed: 21947006
Cell Host Microbe. 2017 Feb 8;21(2):231-243
pubmed: 28132838
FASEB J. 2020 Nov;34(11):15417-15430
pubmed: 32969062
Nature. 2019 Mar;567(7748):394-398
pubmed: 30842653
PLoS One. 2019 May 23;14(5):e0216678
pubmed: 31120925
J Allergy Clin Immunol. 2017 Apr;139(4):1396-1399.e12
pubmed: 28041677
Nat Microbiol. 2017 Mar 27;2:17037
pubmed: 28346446
J Med Chem. 2021 Aug 12;64(15):10967-10980
pubmed: 34338527
Cell. 2012 Apr 13;149(2):358-70
pubmed: 22500802
J Immunol. 2014 Nov 15;193(10):4779-82
pubmed: 25320273
J Med Chem. 2019 Dec 12;62(23):10676-10690
pubmed: 31715099
Immunity. 2010 Nov 24;33(5):765-76
pubmed: 21074459
PLoS One. 2012;7(2):e30802
pubmed: 22312431
Trends Immunol. 2017 Oct;38(10):733-743
pubmed: 28416447
Genes Immun. 2011 Jun;12(4):263-9
pubmed: 21248775
J Virol. 2017 Jul 27;91(16):
pubmed: 28592536
Cell Death Differ. 2019 Sep;26(9):1735-1749
pubmed: 30568238
Nat Microbiol. 2019 Dec;4(12):2552-2564
pubmed: 31659299
Immunity. 2016 Sep 20;45(3):555-569
pubmed: 27637147
Annu Rev Immunol. 2014;32:513-45
pubmed: 24555472