The Replacement of Only One Portion of Starchy Carbohydrates with Green Leafy Vegetables Regresses Mid and Advanced Stages of NAFLD: Results from a Prospective Pilot Study.

FibroScan green leafy vegetables non-alcoholic fatty liver disease (NAFLD) transient elastography

Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
12 May 2023
Historique:
received: 29 03 2023
revised: 04 05 2023
accepted: 09 05 2023
medline: 29 5 2023
pubmed: 27 5 2023
entrez: 27 5 2023
Statut: epublish

Résumé

The gold standard treatment for NAFLD is weight loss and lifestyle interventions, which require a diet enriched in fiber and reduced in sugars and saturated fats. Fibres may be advantageous for NAFLD patients since they reduce and slow the absorption of carbohydrates, lipids, and proteins, lowering the energy density of the meal and increasing their sense of satiety. Furthermore, the polyphenol content and other bioactive compounds of vegetables have antioxidant and anti-inflammatory properties preventing disease progression. The aim of this study is to ascertain the effects of a diet enriched by green leafy vegetables and with a moderate restriction of carbohydrate intake in patients with NAFLD over a three month period. Among the forty patients screened, twenty four patients completed the clinical trial consisting of swapping one portion of carbohydrate-rich food for one portion of green leafy vegetables, and liver and metabolic markers of NAFLD were evaluated. All patients underwent routine blood tests, anthropometric measurements, bioelectrical impedance analysis, fibroscan, and fatty liver index (FLI) evaluation before and at the end of the study. The population under study (

Identifiants

pubmed: 37242172
pii: nu15102289
doi: 10.3390/nu15102289
pmc: PMC10222437
pii:
doi:

Substances chimiques

Starch 9005-25-8

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Références

Clin Chem. 1990 Jan;36(1):15-9
pubmed: 2297909
Hepatology. 2019 Jun;69(6):2672-2682
pubmed: 30179269
Nutrients. 2018 Jan 31;10(2):
pubmed: 29385034
Liver Int. 2012 May;32(5):701-11
pubmed: 22221818
J Clin Invest. 2021 Dec 15;131(24):
pubmed: 34907907
World J Gastroenterol. 2016 Aug 21;22(31):7006-16
pubmed: 27610012
Ann Intern Med. 2020 Jun 16;172(12):786-794
pubmed: 32423348
Eur J Clin Invest. 2022 Mar;52(3):e13659
pubmed: 34309833
Food Funct. 2022 Aug 15;13(16):8348-8362
pubmed: 35899794
BMC Gastroenterol. 2022 May 27;22(1):265
pubmed: 35624410
Eur J Clin Nutr. 2019 Feb;73(2):194-199
pubmed: 30297760
Nutrients. 2022 Oct 29;14(21):
pubmed: 36364821
Asia Pac J Clin Nutr. 2020;29(3):483-490
pubmed: 32990607
Clin Gastroenterol Hepatol. 2022 Dec;20(12):2809-2817.e28
pubmed: 34890795
Lancet Gastroenterol Hepatol. 2022 Sep;7(9):851-861
pubmed: 35798021
Nutr Metab Cardiovasc Dis. 2021 Jun 7;31(6):1691-1701
pubmed: 33838994
J Clin Endocrinol Metab. 2014 Dec;99(12):E2599-609
pubmed: 25157543
Clin Nutr ESPEN. 2020 Feb;35:47-62
pubmed: 31987121
Nutr Metab Cardiovasc Dis. 2009 Oct;19(8):563-70
pubmed: 19176282
Hepatology. 2016 Jul;64(1):73-84
pubmed: 26707365
Nat Rev Gastroenterol Hepatol. 2018 Jan;15(1):11-20
pubmed: 28930295
J Hepatol. 2016 Jun;64(6):1388-402
pubmed: 27062661
BMJ. 2008 Sep 11;337:a1344
pubmed: 18786971
Clin Endocrinol (Oxf). 2003 Aug;59(2):258-62
pubmed: 12864805
ESC Heart Fail. 2022 Oct;9(5):3198-3209
pubmed: 35769032
Hepatology. 2018 Jan;67(1):328-357
pubmed: 28714183
Nutr Res Rev. 2022 Dec;35(2):252-267
pubmed: 34176536
Nutrients. 2019 Dec 05;11(12):
pubmed: 31817398
Sci Rep. 2015 Aug 10;5:12951
pubmed: 26256414
Aliment Pharmacol Ther. 2020 Oct;52(7):1185-1194
pubmed: 33016540
J Sport Health Sci. 2019 May;8(3):197-200
pubmed: 31193291
Front Nutr. 2020 Nov 19;7:593735
pubmed: 33330594
Horm Res. 2008;70(1):51-7
pubmed: 18493150
Drug Discov Ther. 2015 Dec;9(6):380-5
pubmed: 26781921
Ultrasound Med Biol. 2018 Dec;44(12):2419-2440
pubmed: 30209008
Liver Int. 2017 Dec;37(12):1907-1915
pubmed: 28581252
Nutrition. 2017 Jun;38:54-60
pubmed: 28526383
Nutrients. 2019 Jun 07;11(6):
pubmed: 31181664
Lancet Gastroenterol Hepatol. 2020 Apr;5(4):362-373
pubmed: 32027858
Public Health Nutr. 2018 Aug;21(11):2088-2095
pubmed: 29607802
Nutrients. 2020 Sep 01;12(9):
pubmed: 32883047
Curr Opin Clin Nutr Metab Care. 2023 Mar 1;26(2):65-71
pubmed: 36892956
Molecules. 2017 Dec 23;23(1):
pubmed: 29295478
Lancet. 2021 Jun 5;397(10290):2212-2224
pubmed: 33894145
Prim Care Diabetes. 2016 Aug;10(4):272-80
pubmed: 26778708

Auteurs

Sara De Nucci (S)

Unit of Geriatrics and Internal Medicine, National Institute of Gastroenterology-IRCCS "Saverio de Bellis", Via Turi 27, 70013 Castellana Grotte, Bari, Italy.

Roberta Rinaldi (R)

Unit of Geriatrics and Internal Medicine, National Institute of Gastroenterology-IRCCS "Saverio de Bellis", Via Turi 27, 70013 Castellana Grotte, Bari, Italy.

Martina Di Chito (M)

Unit of Geriatrics and Internal Medicine, National Institute of Gastroenterology-IRCCS "Saverio de Bellis", Via Turi 27, 70013 Castellana Grotte, Bari, Italy.

Rossella Donghia (R)

Unit of Data Science, National Institute of Gastroenterology-IRCCS "Saverio de Bellis", Via Turi 27, 70013 Castellana Grotte, Bari, Italy.

Vito Giannuzzi (V)

Department of Gastroenterology, National Institute of Gastroenterology-IRCCS "Saverio de Bellis", Via Turi 27, 70013 Castellana Grotte, Bari, Italy.

Endrit Shahini (E)

Department of Gastroenterology, National Institute of Gastroenterology-IRCCS "Saverio de Bellis", Via Turi 27, 70013 Castellana Grotte, Bari, Italy.

Raffaele Cozzolongo (R)

Department of Gastroenterology, National Institute of Gastroenterology-IRCCS "Saverio de Bellis", Via Turi 27, 70013 Castellana Grotte, Bari, Italy.

Pasqua Letizia Pesole (PL)

National Institute of Gastroenterology-IRCCS "Saverio de Bellis", Via Turi 27, 70013 Castellana Grotte, Bari, Italy.

Sergio Coletta (S)

National Institute of Gastroenterology-IRCCS "Saverio de Bellis", Via Turi 27, 70013 Castellana Grotte, Bari, Italy.

Giovanni De Pergola (G)

Unit of Geriatrics and Internal Medicine, National Institute of Gastroenterology-IRCCS "Saverio de Bellis", Via Turi 27, 70013 Castellana Grotte, Bari, Italy.

Gianluigi Giannelli (G)

Scientific Direction, National Institute of Gastroenterology-IRCCS "Saverio de Bellis", Via Turi 27, 70013 Castellana Grotte, Bari, Italy.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH