Genes Involved in miRNA Biogenesis Are Not Downregulated in SARS-CoV-2 Infection.
Ago2
COVID-19
DGCR8
Dicer
Drosha
Exportin-5
RNA interference
SARS-CoV-2
miRNA
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
16 05 2023
16 05 2023
Historique:
received:
21
04
2023
revised:
11
05
2023
accepted:
12
05
2023
medline:
29
5
2023
pubmed:
27
5
2023
entrez:
27
5
2023
Statut:
epublish
Résumé
miRNAs, small non-coding RNAs that regulate gene expression, are involved in various pathological processes, including viral infections. Virus infections may interfere with the miRNA pathway through the inhibition of genes involved in miRNA biogenesis. A reduction in the number and the levels of miRNAs expressed in nasopharyngeal swabs of patients with severe COVID-19 was lately observed by us, pointing towards the potential of miRNAs as possible diagnostic or prognostic biomarkers for predicting outcomes among patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The objective of the present study was to investigate whether SARS-CoV-2 infection influences the expression levels of messenger RNAs (mRNAs) of key genes involved in miRNA biogenesis. mRNA levels of
Identifiants
pubmed: 37243263
pii: v15051177
doi: 10.3390/v15051177
pmc: PMC10222706
pii:
doi:
Substances chimiques
MicroRNAs
0
RNA-Binding Proteins
0
RNA, Messenger
0
DICER1 protein, human
EC 3.1.26.3
Ribonuclease III
EC 3.1.26.3
DEAD-box RNA Helicases
EC 3.6.4.13
XPO5 protein, human
0
Karyopherins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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