Loss of Residues 119-136, Including the First β-strand of Human Prion Protein, Generates an Aggregation-competent Partially "Open" Form.

Humans Prion Proteins / chemistry Protein Conformation, beta-Strand Protein Folding
biophysics hydrogen-deuterium exchange neurodegeneration prion protein

Journal

Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R

Informations de publication

Date de publication:
01 08 2023
Historique:
received: 18 11 2022
revised: 18 05 2023
accepted: 19 05 2023
medline: 21 7 2023
pubmed: 28 5 2023
entrez: 27 5 2023
Statut: ppublish

Résumé

In prion replication, the cellular form of prion protein (PrP

Identifiants

DOI: 10.1016/j.jmb.2023.168158 PMID: 37244570
pubmed: 37244570
pii: S0022-2836(23)00243-7
doi: 10.1016/j.jmb.2023.168158
pii:
doi:

Substances chimiques

Prion Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

168158

Subventions

Organisme : Medical Research Council
ID : MC_UU_00024/6
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R21 NS101588
Pays : United States

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: J.C. is a Director and shareholder of D-Gen Limited, an academic spin-out company working in the field of prion disease diagnosis, decontamination, and therapeutics. The other authors declare no competing interests.

Auteurs

Laszlo L P Hosszu (LLP)

MRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London W1W 7FF, UK(†).

Daljit Sangar (D)

MRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London W1W 7FF, UK(†).

Mark Batchelor (M)

MRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London W1W 7FF, UK(†).

Emmanuel Risse (E)

MRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London W1W 7FF, UK(†).

Andrea M Hounslow (AM)

Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK.

John Collinge (J)

MRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London W1W 7FF, UK(†).

Jonathan P Waltho (JP)

Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK; Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK.

Jan Bieschke (J)

MRC Prion Unit at UCL, UCL Institute of Prion Diseases, 33 Cleveland Street, London W1W 7FF, UK(†). Electronic address: j.bieschke@prion.ucl.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Loss of Residues 119-136, Including the First...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Prions › Protéines prion › Loss of Residues 119-136, Including the First...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Structure en brin bêta › Loss of Residues 119-136, Including the First...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Pliage des protéines › Loss of Residues 119-136, Including the First...