Necrotizing enterocolitis: recent advances in treatment with translational potential.
Fecal microbiota transplantation
Immunotherapy
Necrotizing enterocolitis
Remote ischemic conditioning
Stem cell
Treatment
Journal
Pediatric surgery international
ISSN: 1437-9813
Titre abrégé: Pediatr Surg Int
Pays: Germany
ID NLM: 8609169
Informations de publication
Date de publication:
29 May 2023
29 May 2023
Historique:
accepted:
19
04
2023
medline:
31
5
2023
pubmed:
29
5
2023
entrez:
29
5
2023
Statut:
epublish
Résumé
Necrotizing enterocolitis (NEC) is one of the most prevalent and devastating gastrointestinal disorders in neonates. Despite advances in neonatal care, the incidence and mortality due to NEC remain high, highlighting the need to devise novel treatments for this disease. There have been a number of recent advancements in therapeutic approaches for the treatment of NEC; these involve remote ischemic conditioning (RIC), stem cell therapy, breast milk components (human milk oligosaccharides, exosomes, lactoferrin), fecal microbiota transplantation, and immunotherapy. This review summarizes the most recent advances in NEC treatment currently underway as well as their applicability and associated challenges and limitations, with the aim to provide new insight into the paradigm of care for NEC worldwide.
Identifiants
pubmed: 37247104
doi: 10.1007/s00383-023-05476-0
pii: 10.1007/s00383-023-05476-0
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
205Subventions
Organisme : CIHR
ID : 353857
Pays : Canada
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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