Modulation of T cells by tryptophan metabolites in the kynurenine pathway.
3-hydroxyanthranilic acid
AHR
GPR35
IDO
IL4i1
T cells
autoimmunity
cancer therapy
immune tolerance
indoleamine 2,3-dioxygenase
kynurenic acid
kynurenine
tryptophan
Journal
Trends in pharmacological sciences
ISSN: 1873-3735
Titre abrégé: Trends Pharmacol Sci
Pays: England
ID NLM: 7906158
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
received:
28
03
2023
revised:
26
04
2023
accepted:
26
04
2023
medline:
12
6
2023
pubmed:
30
5
2023
entrez:
29
5
2023
Statut:
ppublish
Résumé
Lymphocytes maturing in the thymus (T cells) are key factors in adaptive immunity and the regulation of inflammation. The kynurenine pathway of tryptophan metabolism includes several enzymes and compounds that can modulate T cell function, but manipulating these pharmacologically has not achieved the expected therapeutic activity for the treatment of autoimmune disorders and cancer. With increasing knowledge of other pathways interacting with kynurenines, the expansion of screening methods, and the application of virtual techniques to understanding enzyme structures and mechanisms, details of interactions between kynurenines and other pathways are being revealed. This review surveys some of these alternative approaches to influence T cell function indirectly via the kynurenine pathway and summarizes the most recent work on the development of compounds acting directly on the kynurenine pathway.
Identifiants
pubmed: 37248103
pii: S0165-6147(23)00089-5
doi: 10.1016/j.tips.2023.04.006
pii:
doi:
Substances chimiques
Kynurenine
343-65-7
Tryptophan
8DUH1N11BX
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
442-456Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.