Protein phase separation: new insights into cell division.
biomolecular condensate
cell division
liquid-liquid phase separation
Journal
Acta biochimica et biophysica Sinica
ISSN: 1745-7270
Titre abrégé: Acta Biochim Biophys Sin (Shanghai)
Pays: China
ID NLM: 101206716
Informations de publication
Date de publication:
30 May 2023
30 May 2023
Historique:
medline:
11
8
2023
pubmed:
30
5
2023
entrez:
30
5
2023
Statut:
ppublish
Résumé
As the foundation for the development of multicellular organisms and the self-renewal of single cells, cell division is a highly organized event which segregates cellular components into two daughter cells equally or unequally, thus producing daughters with identical or distinct fates. Liquid-liquid phase separation (LLPS), an emerging biophysical concept, provides a new perspective for us to understand the mechanisms of a wide range of cellular events, including the organization of membrane-less organelles. Recent studies have shown that several key organelles in the cell division process are assembled into membrane-free structures via LLPS of specific proteins. Here, we summarize the regulatory functions of protein phase separation in centrosome maturation, spindle assembly and polarity establishment during cell division.
Identifiants
pubmed: 37249333
doi: 10.3724/abbs.2023093
pmc: PMC10415187
doi:
Substances chimiques
Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1042-1051Références
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