Multi-view carotid ultrasound is stronger associated with cardiovascular risk factors than presence of plaque or single carotid intima media thickness measurements in subclinical atherosclerosis.
Male
Middle Aged
Humans
Female
Carotid Intima-Media Thickness
Cardiovascular Diseases
/ diagnostic imaging
Carotid Artery Diseases
/ diagnostic imaging
Ultrasonography, Carotid Arteries
Risk Factors
Predictive Value of Tests
Plaque, Atherosclerotic
Atherosclerosis
/ complications
Carotid Arteries
/ diagnostic imaging
Heart Disease Risk Factors
Atherosclerosis
Cardiovascular disease
Carotid intima media thickness
Carotid plaque
Carotid ultrasound
Journal
The international journal of cardiovascular imaging
ISSN: 1875-8312
Titre abrégé: Int J Cardiovasc Imaging
Pays: United States
ID NLM: 100969716
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
03
12
2022
accepted:
03
05
2023
medline:
17
8
2023
pubmed:
30
5
2023
entrez:
30
5
2023
Statut:
ppublish
Résumé
We aimed to explore the prevalence of atherosclerosis by using multi-view ultrasound examination of the carotid arteries and its association with clinical risk factors in a middle-aged population at low to intermediate risk of cardiovascular disease (CVD). Carotid vascular ultrasound was performed in 3532 participants in the VIPVIZA trial. Mean and maximal carotid intima media thickness (cIMT) at prespecified angles and plaque presence were examined on the left and right side. Associations between CVD risk factors and ultrasound variables were quantified by partial least squares (PLS) regression. A combined ultrasound variable was computed using weights of the first PLS component. Associations between CVD risk factors and the combined multi-view ultrasound variable, single cIMT and plaque measurements, respectively, were determined using linear regression modelling. The participants' mean age was 55.7 years and 52.9% were women. Plaque prevalence was 51.1% in men and 39.0% in women. cIMT was higher in men than in women and in the left compared with the right carotid artery. The strongest association of CVD risk factors was observed with the combined multi-view ultrasound variable (R2 = 24%), compared with single cIMT variables (R2 = 14-18%) and plaque presence (R2 = 15%). The pattern was similar in both sexes. The association with CVD risk factors and the combined ultrasound variable was stronger in 40-year olds (R2 = 22%) compared with 50- or 60-year olds (R = 12%). CVD risk factors are stronger associated with a combined ultrasound variable than plaque presence or single cIMT measures suggesting that carotid multi-view ultrasonography better captures the focality of early atherosclerosis.Clinical Trial Registration: ClinicalTrials.gov, number NCT01849575. May 8, 2013.
Identifiants
pubmed: 37249653
doi: 10.1007/s10554-023-02868-0
pii: 10.1007/s10554-023-02868-0
pmc: PMC10427531
doi:
Banques de données
ClinicalTrials.gov
['NCT01849575']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1461-1471Informations de copyright
© 2023. The Author(s).
Références
Mortality GBD, Causes of Death C (2016) Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the global burden of Disease Study 2015. Lancet 388:1459–1544. https://doi.org/10.1016/S0140-6736(16)31012-1
doi: 10.1016/S0140-6736(16)31012-1
O’Donnell MJ, Xavier D, Liu L, Zhang H, Chin SL, Rao-Melacini P, Rangarajan S, Islam S, Pais P, McQueen MJ, Mondo C, Damasceno A, Lopez-Jaramillo P, Hankey GJ, Dans AL, Yusoff K, Truelsen T, Diener HC, Sacco RL, Ryglewicz D, Czlonkowska A, Weimar C, Wang X, Yusuf S (2010) investigators I Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet 376:112 – 23. https://doi.org/10.1016/S0140-6736(10)60834-3
Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, McQueen M, Budaj A, Pais P, Varigos J, Lisheng L, Investigators IS (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 364:937–952. https://doi.org/10.1016/S0140-6736(04)17018-9
doi: 10.1016/S0140-6736(04)17018-9
pubmed: 15364185
Bauer M, Delaney JA, Mohlenkamp S, Jockel KH, Kronmal RA, Lehmann N, Mukamal KJ, Moebus S, Polak JF, Dragano N, Budoff MJ, Erbel R, McClelland RL, Investigator Group of the Heinz Nixdorf Recall S (2013) Multi-Ethnic Study of A, Comparison of factors associated with carotid intima-media thickness in the Multi-ethnic Study of Atherosclerosis (MESA) and the Heinz Nixdorf Recall Study (HNR). Journal of the American Society of Echocardiography 26:667 – 73. https://doi.org/10.1016/j.echo.2013.03.011
Bian L, Xia L, Wang Y, Jiang J, Zhang Y, Li D, Li W, He Y (2018) Risk factors of subclinical atherosclerosis and plaque burden in high risk individuals: results from a community-based study. Front Physiol 9:739. https://doi.org/10.3389/fphys.2018.00739
doi: 10.3389/fphys.2018.00739
pubmed: 29988372
pmcid: 6023999
Nilsson Wadstrom B, Engstrom G, Nilsson PM (2021) Exploring and comparing definitions of healthy vascular ageing in the population: characteristics and prospective cardiovascular risk. J Hum Hypertens 35:428–436. https://doi.org/10.1038/s41371-020-0353-1
doi: 10.1038/s41371-020-0353-1
pubmed: 32415282
Fernandez-Alvarez V, Linares Sanchez M, Lopez Alvarez F, Suarez Nieto C, Makitie AA, Olsen KD, Ferlito A (2022) Evaluation of Intima-Media thickness and arterial stiffness as early ultrasound biomarkers of carotid artery atherosclerosis. Cardiol Ther 11:231–247. https://doi.org/10.1007/s40119-022-00261-x
doi: 10.1007/s40119-022-00261-x
pubmed: 35362868
pmcid: 9135926
Gepner AD, Young R, Delaney JA, Tattersall MC, Blaha MJ, Post WS, Gottesman RF, Kronmal R, Budoff MJ, Burke GL, Folsom AR, Liu K, Kaufman J, Stein JH (2015) Comparison of coronary artery calcium presence, carotid plaque presence, and carotid intima-media thickness for cardiovascular disease prediction in the multi-ethnic study of atherosclerosis. Circulation Cardiovasc imaging 8. https://doi.org/10.1161/CIRCIMAGING.114.002262
Paraskevas KI, Sillesen HH, Rundek T, Mathiesen EB, Spence JD (2020) Carotid intima-media thickness Versus Carotid Plaque Burden for Predicting Cardiovascular Risk. Angiology 71:108–111. https://doi.org/10.1177/0003319719878582
doi: 10.1177/0003319719878582
pubmed: 31569951
Georgiopoulos G, Mavraganis G, Delialis D, Georgiou S, Aivalioti E, Patras R, Petropoulos I, Dimopoulou MA, Angelidakis L, Sianis A, Bampatsias D, Dimoula A, Maneta E, Kosmopoulos M, Vardavas C, Stellos K, Stamatelopoulos K (2022) Carotid ultrasonography improves residual risk stratification in guidelines-defined high cardiovascular risk patients. Eur J Prev Cardiol 29:1773–1784. https://doi.org/10.1093/eurjpc/zwac095
doi: 10.1093/eurjpc/zwac095
pubmed: 35580589
Naqvi TZ, Lee MS (2014) Carotid intima-media thickness and plaque in cardiovascular risk assessment. JACC Cardiovasc imaging 7:1025–1038. https://doi.org/10.1016/j.jcmg.2013.11.014
doi: 10.1016/j.jcmg.2013.11.014
pubmed: 25051948
Polak JF, O’Leary DH (2016) Carotid intima-media thickness as surrogate for and predictor of CVD. Glob Heart 11:295–312. https://doi.org/10.1016/j.gheart.2016.08.006
doi: 10.1016/j.gheart.2016.08.006
pubmed: 27741977
Stein JH, Korcarz CE, Hurst RT, Lonn E, Kendall CB, Mohler ER, Najjar SS, Rembold CM, Post WS, American Society of Echocardiography Carotid Intima-Media Thickness, Task F (2008) Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am Soc Echocardiogr 21:93–111 quiz 189 – 90. https://doi.org/10.1016/j.echo.2007.11.011
doi: 10.1016/j.echo.2007.11.011
pubmed: 18261694
Luo X, Yang Y, Cao T, Li Z (2011) Differences in left and right carotid intima-media thickness and the associated risk factors. Clin Radiol 66:393–398. https://doi.org/10.1016/j.crad.2010.12.002
doi: 10.1016/j.crad.2010.12.002
pubmed: 21324442
Ma SM, Wei CK, Liang CC, Chou JM, Lee SY (2011) The age correlation of the carotid intima-media thickness according to sex and side in asymptomatic subjects. Acta Neurol Taiwan 20:29–34
pubmed: 21249586
Peters SA, den Ruijter HM, Palmer MK, Grobbee DE, Crouse JR 3rd, O’Leary DH, Evans GW, Raichlen JS, Bots ML, Investigators MS (2012) Extensive or restricted ultrasound protocols to measure carotid intima-media thickness: analysis of completeness rates and impact on observed rates of change over time. J Am Soc Echocardiogr 25:91–100. https://doi.org/10.1016/j.echo.2011.09.009
Polak JF, Pencina MJ, Meisner A, Pencina KM, Brown LS, Wolf PA, D’Agostino RBS (2010) Associations of carotid artery intima-media thickness (IMT) with risk factors and prevalent cardiovascular disease: comparison of mean common carotid artery IMT with maximum internal carotid artery IMT. J Ultrasound Med 29:1759–1768. https://doi.org/10.7863/jum.2010.29.12.1759
doi: 10.7863/jum.2010.29.12.1759
pubmed: 21098848
pmcid: 3186063
Kuo F, Gardener H, Dong C, Cabral D, Della-Morte D, Blanton SH, Elkind MS, Sacco RL, Rundek T (2012) Traditional cardiovascular risk factors explain the minority of the variability in carotid plaque. Stroke 43:1755–1760. https://doi.org/10.1161/STROKEAHA.112.651059
doi: 10.1161/STROKEAHA.112.651059
pubmed: 22550054
pmcid: 3383876
Polak JF, Person SD, Wei GS, Godreau A, Jacobs DR Jr, Harrington A, Sidney S, O’Leary DH (2010) Segment-specific associations of carotid intima-media thickness with cardiovascular risk factors: the coronary artery Risk Development in Young adults (CARDIA) study. Stroke 41:9–15. https://doi.org/10.1161/STROKEAHA.109.566596
Naslund U, Ng N, Lundgren A, Fharm E, Gronlund C, Johansson H, Lindahl B, Lindahl B, Lindvall K, Nilsson SK, Nordin M, Nordin S, Nyman E, Rocklov J, Vanoli D, Weinehall L, Wennberg P, Wester P, Norberg M, group Vt (2019) Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention (VIPVIZA): a pragmatic, open-label, randomised controlled trial. Lancet 393:133–142. https://doi.org/10.1016/S0140-6736(18)32818-6
doi: 10.1016/S0140-6736(18)32818-6
pubmed: 30522919
Norberg M, Wall S, Boman K, Weinehall L (2010) The Vasterbotten Intervention Programme: background, design and implications. Global health action 3. https://doi.org/10.3402/gha.v3i0.4643
Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. https://doi.org/10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S. 15:539 – 53
doi: 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
pubmed: 9829761
Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972 Jun;18(6):499–502
Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N, Csiba L, Desvarieux M, Ebrahim S, Fatar M, Hernandez Hernandez R, Jaff M, Kownator S, Prati P, Rundek T, Sitzer M, Schminke U, Tardif JC, Taylor A, Vicaut E, Woo KS, Zannad F, Zureik M (2007) Mannheim carotid intima-media thickness consensus (2004–2006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006. Cerebrovasc Dis 23:75–80. https://doi.org/10.1159/000097034
Nyman E, Vanoli D, Naslund U, Gronlund C (2020) Inter-sonographer reproducibility of carotid ultrasound plaque detection using Mannheim consensus in subclinical atherosclerosis. Clin Physiol Funct Imaging 40:46–51. https://doi.org/10.1111/cpf.12602
doi: 10.1111/cpf.12602
pubmed: 31605665
Vanoli D, Lindqvist P, Wiklund U, Henein M, Naslund U Fully automated on-screen carotid intima-media thickness measurement: a screening tool for subclinical atherosclerosis.Journal of clinical ultrasound41:333–9. https://doi.org/10.1002/jcu.22041
Krishnan A, Williams LJ, McIntosh AR, Abdi H (2011) Partial least squares (PLS) methods for neuroimaging: a tutorial and review. NeuroImage 56:455–475. https://doi.org/10.1016/j.neuroimage.2010.07.034
doi: 10.1016/j.neuroimage.2010.07.034
pubmed: 20656037
Thorsson B, Eiriksdottir G, Sigurdsson S, Gudmundsson EF, Bots ML, Aspelund T, Arntzen KA, Mathiesen EB, Gudnason V (2018) Population distribution of traditional and the emerging cardiovascular risk factors carotid plaque and IMT: the REFINE-Reykjavik study with comparison with the Tromso study. BMJ open 8:e019385. https://doi.org/10.1136/bmjopen-2017-019385
doi: 10.1136/bmjopen-2017-019385
pubmed: 29858406
pmcid: 5988050
Zeb I, Budoff MJ (2011) MESA: the NIH-sponsored study that validates atherosclerosis imaging for primary prevention. Curr Atheroscler Rep 13:353–358. https://doi.org/10.1007/s11883-011-0191-2
doi: 10.1007/s11883-011-0191-2
pubmed: 21785969
Polak JF, Szklo M, O’Leary DH Associations of Coronary Heart Disease with Common Carotid Artery Near and Far Wall Intima-Media thickness: the multi-ethnic study of atherosclerosis.Journal of the American Society of Echocardiography28:1114–21. https://doi.org/10.1016/j.echo.2015.04.001
Barnett PA, Spence JD, Manuck SB, Jennings JR (1997) Psychological stress and the progression of carotid artery disease. J Hypertens 15:49–55. https://doi.org/10.1097/00004872-199715010-00004
doi: 10.1097/00004872-199715010-00004
pubmed: 9050970
Zanchetti A, Bond MG, Hennig M, Neiss A, Mancia G, Dal Palu C, Hansson L, Magnani B, Rahn KH, Reid J, Rodicio J, Safar M, Eckes L, Ravinetto R (1998) Risk factors associated with alterations in carotid intima-media thickness in hypertension: baseline data from the european Lacidipine study on atherosclerosis. J Hypertens 16:949–961. https://doi.org/10.1097/00004872-199816070-00008
doi: 10.1097/00004872-199816070-00008
pubmed: 9794735
Sturlaugsdottir R, Aspelund T, Bjornsdottir G, Sigurdsson S, Thorsson B, Eiriksdottir G, Gudnason V (2016) Prevalence and determinants of carotid plaque in the cross-sectional REFINE-Reykjavik study. BMJ open 6:e012457. https://doi.org/10.1136/bmjopen-2016-012457
doi: 10.1136/bmjopen-2016-012457
pubmed: 27884845
pmcid: 5168519
Ihle-Hansen H, Vigen T, Ihle-Hansen H, Ronning OM, Berge T, Thommessen B, Lyngbakken MN, Orstad EB, Enger S, Nygard S, Rosjo H, Tveit A (2018) Prevalence of Carotid Plaque in a 63- to 65-Year-old norwegian cohort from the General Population: the ACE (Akershus Cardiac examination) 1950 study. J Am Heart Association 7. https://doi.org/10.1161/JAHA.118.008562
Ostgren CJ, Soderberg S, Festin K, Angeras O, Bergstrom G, Blomberg A, Brandberg J, Cederlund K, Eliasson M, Engstrom G, Erlinge D, Fagman E, Hagstrom E, Lind L, Mannila M, Nilsson U, Oldgren J, Ostenfeld E, Persson A, Persson J, Persson M, Rosengren A, Sundstrom J, Swahn E, Engvall JE, Jernberg T (2020) Systematic coronary risk evaluation estimated risk and prevalent subclinical atherosclerosis in coronary and carotid arteries: a population-based cohort analysis from the swedish cardiopulmonary Bioimage Study. Eur J Prev Cardiol 3:2047487320909300. https://doi.org/10.1177/2047487320909300
doi: 10.1177/2047487320909300
Li R, Duncan BB, Metcalf PA, Crouse JR 3rd, Sharrett AR, Tyroler HA, Barnes R, Heiss G (1994) B-mode-detected carotid artery plaque in a general population. Atherosclerosis risk in Communities (ARIC) Study investigators. Stroke 25:2377–2383. https://doi.org/10.1161/01.str.25.12.2377
Norberg M, Blomstedt Y, Lonnberg G, Nystrom L, Stenlund H, Wall S, Weinehall L (2012) Community participation and sustainability–evidence over 25 years in the Vasterbotten intervention Programme. Global health action 5:1–9. https://doi.org/10.3402/gha.v5i0.19166
doi: 10.3402/gha.v5i0.19166
pubmed: 23528041
Polonsky TS, Greenland P (2012) CVD screening in low-risk, asymptomatic adults: clinical trials needed. Nat reviews Cardiol 9:599–604. https://doi.org/10.1038/nrcardio.2012.114
doi: 10.1038/nrcardio.2012.114
Bengtsson A, Norberg M, Ng N, Carlberg B, Gronlund C, Hultdin J, Lindahl B, Lindahl B, Nordin S, Nyman E, Wennberg P, Wester P, Naslund U (2021) The beneficial effect over 3 years by pictorial information to patients and their physician about subclinical atherosclerosis and cardiovascular risk: results from the VIPVIZA randomized clinical trial. Am J Prev Cardiol 7:100199. https://doi.org/10.1016/j.ajpc.2021.100199
doi: 10.1016/j.ajpc.2021.100199
pubmed: 34611639
pmcid: 8387279
Spence JD, Eliasziw M, DiCicco M, Hackam DG, Galil R, Lohmann T (2002) Carotid plaque area: a tool for targeting and evaluating vascular preventive therapy. Stroke 33:2916–2922. https://doi.org/10.1161/01.str.0000042207.16156.b9
doi: 10.1161/01.str.0000042207.16156.b9
pubmed: 12468791
Herder M, Johnsen SH, Arntzen KA, Mathiesen EB (2012) Risk factors for progression of carotid intima-media thickness and total plaque area: a 13-year follow-up study: the Tromso Study. Stroke 43:1818–1823. https://doi.org/10.1161/STROKEAHA.111.646596
doi: 10.1161/STROKEAHA.111.646596
pubmed: 22550052
Fenster A, Landry A, Downey DB, Hegele RA, Spence JD (2004) 3D ultrasound imaging of the carotid arteries. Curr Drug Targets Cardiovasc Haematol Disord 4:161–175. https://doi.org/10.2174/1568006043336311
doi: 10.2174/1568006043336311
pubmed: 15180488