Dynamic changes of phenotype and function of natural killer cells in peripheral blood before and after thermal ablation of hepatitis B associated hepatocellular carcinoma and their correlation with tumor recurrence.
Hepatocellular carcinoma
Natural killer cells
Thermal ablation
Journal
BMC cancer
ISSN: 1471-2407
Titre abrégé: BMC Cancer
Pays: England
ID NLM: 100967800
Informations de publication
Date de publication:
30 May 2023
30 May 2023
Historique:
received:
10
03
2022
accepted:
06
04
2023
medline:
1
6
2023
pubmed:
31
5
2023
entrez:
30
5
2023
Statut:
epublish
Résumé
Thermal therapy induces an immune response in patients with hepatocellular carcinoma (HCC), but the dynamic characteristics of the natural killer (NK) cell immune response post-thermal ablation remain unclear. We conducted a prospective longitudinal cohort study to observe the dynamic changes of phenotype and function of NK cells in peripheral blood before and after thermal ablation of hepatitis B-associated HCC and their correlation with tumor recurrence. Fifty-six patients clinically and pathologically confirmed with hepatitis B-associated HCC were selected for thermal ablation. Peripheral blood was collected on day 0, day 7, and month 1. NK cell subsets, receptors, and killing function were detected by flow cytometry, and the LDH levels were examined. Overall recurrence and associated variables were estimated using Kaplan-Meier, log-rank, and Cox proportional-hazards analyses. The frequency of CD3 Thermal ablation increased the frequency and function of CD3
Sections du résumé
BACKGROUND
BACKGROUND
Thermal therapy induces an immune response in patients with hepatocellular carcinoma (HCC), but the dynamic characteristics of the natural killer (NK) cell immune response post-thermal ablation remain unclear. We conducted a prospective longitudinal cohort study to observe the dynamic changes of phenotype and function of NK cells in peripheral blood before and after thermal ablation of hepatitis B-associated HCC and their correlation with tumor recurrence.
METHODS
METHODS
Fifty-six patients clinically and pathologically confirmed with hepatitis B-associated HCC were selected for thermal ablation. Peripheral blood was collected on day 0, day 7, and month 1. NK cell subsets, receptors, and killing function were detected by flow cytometry, and the LDH levels were examined. Overall recurrence and associated variables were estimated using Kaplan-Meier, log-rank, and Cox proportional-hazards analyses.
RESULTS
RESULTS
The frequency of CD3
CONCLUSION
CONCLUSIONS
Thermal ablation increased the frequency and function of CD3
Identifiants
pubmed: 37254046
doi: 10.1186/s12885-023-10823-4
pii: 10.1186/s12885-023-10823-4
pmc: PMC10228897
doi:
Substances chimiques
Granzymes
EC 3.4.21.-
Perforin
126465-35-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
486Informations de copyright
© 2023. The Author(s).
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