Prevalence and molecular analysis of glucose-6-phosphate dehydrogenase deficiency in Chin State, Myanmar.
Chin State
Glucose-6-phosphate dehydrogenase deficiency
Myanmar
variant
Journal
Parasites, hosts and diseases
ISSN: 2982-6799
Titre abrégé: Parasites Hosts Dis
Pays: Korea (South)
ID NLM: 9918574074806676
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
10
01
2023
accepted:
05
04
2023
medline:
2
6
2023
pubmed:
1
6
2023
entrez:
31
5
2023
Statut:
ppublish
Résumé
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is caused by X-linked recessive disorderliness. It induces severe anemia when a patient with G6PD deficiency is exposed to oxidative stress that occurs with administration of an antimalarial drug, primaquine. The distribution of G6PD deficiency remains unknown while primaquine has been used for malaria treatment in Myanmar. This study aimed to investigate the prevalence of G6PD deficiency and its variants in Chin State, Myanmar. Among 322 participants, 18 (11 males and 7 females) demonstrated a G6PD deficiency. Orissa variant was dominant in the molecular analysis. This would be related to neighboring Indian and Bangladeshi population, in which Orissa variant was also reported as the main mutation type. The screening test for G6PD deficiency before primaquine treatment appears to be important in Myanmar.
Identifiants
pubmed: 37258262
pii: PHD.23004
doi: 10.3347/PHD.23004
pmc: PMC10234822
doi:
Substances chimiques
Primaquine
MVR3634GX1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
154-162Références
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