Emerging functions of thrombospondin-1 in immunity.
Antigen presenting cells
Antitumor immunity
Autoimmune disease
CD47
Natural killer cells
T cells
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
01 Mar 2024
01 Mar 2024
Historique:
received:
10
05
2023
accepted:
24
05
2023
pmc-release:
29
11
2024
medline:
7
11
2023
pubmed:
1
6
2023
entrez:
31
5
2023
Statut:
ppublish
Résumé
Thrombospondin-1 is a secreted matricellular glycoprotein that modulates cell behavior by interacting with components of the extracellular matrix and with several cell surface receptors. Its presence in the extracellular matrix is induced by injuries that cause thrombospondin-1 release from platelets and conditions including hyperglycemia, ischemia, and aging that stimulate its expression by many cell types. Conversely, rapid receptor-mediated clearance of thrombospondin-1 from the extracellular space limits its sustained presence in the extracellular space and maintains sub-nanomolar physiological concentrations in blood plasma. Roles for thrombospondin-1 signaling, mediated by specific cellular receptors or by activation of latent TGFβ, have been defined in T and B lymphocytes, natural killer cells, macrophages, neutrophils, and dendritic cells. In addition to regulating physiological nitric oxide signaling and responses of cells to stress, studies in mice lacking thrombospondin-1 or its receptors have revealed important roles for thrombospondin-1 in regulating immune responses in infectious and autoimmune diseases and antitumor immunity.
Identifiants
pubmed: 37258315
pii: S1084-9521(23)00117-9
doi: 10.1016/j.semcdb.2023.05.008
pmc: PMC10684827
mid: NIHMS1905548
pii:
doi:
Substances chimiques
CD47 Antigen
0
Thrombospondins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
22-31Subventions
Organisme : Intramural NIH HHS
ID : Z01 SC009172
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA SC009172
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA SC009174
Pays : United States
Informations de copyright
Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.
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