Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease.

Animals Mice Alzheimer Disease / metabolism Amyloid beta-Peptides / metabolism Disease Models, Animal Myelin Sheath / metabolism Plaque, Amyloid / genetics Axons / metabolism Microglia / metabolism Single-Cell Gene Expression Analysis Risk Factors Disease Progression

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
Jun 2023
Historique:
received: 30 07 2021
accepted: 21 04 2023
medline: 9 6 2023
pubmed: 1 6 2023
entrez: 31 5 2023
Statut: ppublish

Résumé

The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing affects oligodendrocytes and the structural integrity of myelin sheaths

Identifiants

DOI: 10.1038/s41586-023-06120-6 PMID: 37258678 PMC: PMC10247380
pubmed: 37258678
doi: 10.1038/s41586-023-06120-6
pii: 10.1038/s41586-023-06120-6
pmc: PMC10247380
doi:

Substances chimiques

Amyloid beta-Peptides 0
APP protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

349-357

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2023. The Author(s).

Références

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Auteurs

Constanze Depp (C)

Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. depp@mpinat.mpg.de.
ORCID: 0000-0003-2868-6932

Ting Sun (T)

Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
ORCID: 0000-0002-7104-7215

Andrew Octavian Sasmita (AO)

Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

Lena Spieth (L)

Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
German Center for Neurodegenerative Diseases, Munich, Germany.
ORCID: 0000-0002-0308-0144

Stefan A Berghoff (SA)

Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
German Center for Neurodegenerative Diseases, Munich, Germany.

Taisiia Nazarenko (T)

Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

Katharina Overhoff (K)

Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

Agnes A Steixner-Kumar (AA)

Clinical Neuroscience, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

Swati Subramanian (S)

Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

Sahab Arinrad (S)

Clinical Neuroscience, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

Torben Ruhwedel (T)

Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

Wiebke Möbius (W)

Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
ORCID: 0000-0002-2902-7165

Sandra Göbbels (S)

Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

Gesine Saher (G)

Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
ORCID: 0000-0003-3507-9604

Hauke B Werner (HB)

Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
ORCID: 0000-0002-7710-5738

Alkmini Damkou (A)

Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
German Center for Neurodegenerative Diseases, Munich, Germany.
ORCID: 0000-0002-5082-0790

Silvia Zampar (S)

Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany.
ORCID: 0000-0003-0134-0974

Oliver Wirths (O)

Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany.
ORCID: 0000-0002-4115-0334

Maik Thalmann (M)

Department of German Philology, Georg-August University, Göttingen, Germany.
ORCID: 0000-0002-0610-210X

Mikael Simons (M)

Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
German Center for Neurodegenerative Diseases, Munich, Germany.
Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.
ORCID: 0000-0001-5329-192X

Takashi Saito (T)

Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.
Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, Japan.

Takaomi Saido (T)

Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, Japan.
ORCID: 0000-0003-1970-6903

Dilja Krueger-Burg (D)

Department of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany.
Department of Molecular Neurobiology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

Riki Kawaguchi (R)

Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Michael Willem (M)

German Center for Neurodegenerative Diseases, Munich, Germany.
Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.
Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians University of Munich, Munich, Germany.

Christian Haass (C)

German Center for Neurodegenerative Diseases, Munich, Germany.
Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.
Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians University of Munich, Munich, Germany.
ORCID: 0000-0002-4869-1627

Daniel Geschwind (D)

Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
ORCID: 0000-0003-2896-3450

Hannelore Ehrenreich (H)

Clinical Neuroscience, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
ORCID: 0000-0001-8371-5711

Ruth Stassart (R)

Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Paul-Flechsig-Institute of Neuropathology, University Clinic Leipzig, Leipzig, Germany.

Klaus-Armin Nave (KA)

Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. nave@mpinat.mpg.de.
ORCID: 0000-0001-8724-9666

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Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Classifications MeSH

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