Effects of mixed nut consumption on LDL cholesterol, lipoprotein(a), and other cardiometabolic risk factors in overweight and obese adults.
Cardiovascular disease
Inflammation
LDL cholesterol
Lipid profiles
Lipoprotein(a)[Lp(a)]
Mixed nuts
Obesity
Journal
Nutrition, metabolism, and cardiovascular diseases : NMCD
ISSN: 1590-3729
Titre abrégé: Nutr Metab Cardiovasc Dis
Pays: Netherlands
ID NLM: 9111474
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
30
09
2022
revised:
06
05
2023
accepted:
09
05
2023
medline:
10
7
2023
pubmed:
2
6
2023
entrez:
1
6
2023
Statut:
ppublish
Résumé
Elevated LDL-C, lipoprotein(a) [Lp(a)], and inflammation are associated with greater risk for atherosclerotic cardiovascular events. Consumption of individual nut types decreases these risk factors but knowledge about the effect of mixed nuts on Lp(a) is limited. The objective of this study was to determine the effects of consuming 42.5 g/day of mixed nuts on LDL-C, Lp(a), and inflammatory markers in individuals with overweight or obesity. In a 16-week randomized control trial, 29 participants with overweight or obesity (BMI 25-40 kg/m Consumption of mixed nuts had no evidence of an effect on LDL-C or Lp(a) throughout the intervention. Notably, mixed nut consumption lowered body fat percentage without significant changes in body weight or BMI. Future studies with larger sample sizes investigating the changing trends of CRP, 8-oxodG, and TAC are warranted. NCT03375866.
Sections du résumé
BACKGROUND AND AIMS
OBJECTIVE
Elevated LDL-C, lipoprotein(a) [Lp(a)], and inflammation are associated with greater risk for atherosclerotic cardiovascular events. Consumption of individual nut types decreases these risk factors but knowledge about the effect of mixed nuts on Lp(a) is limited. The objective of this study was to determine the effects of consuming 42.5 g/day of mixed nuts on LDL-C, Lp(a), and inflammatory markers in individuals with overweight or obesity.
METHODS AND RESULTS
RESULTS
In a 16-week randomized control trial, 29 participants with overweight or obesity (BMI 25-40 kg/m
CONCLUSION
CONCLUSIONS
Consumption of mixed nuts had no evidence of an effect on LDL-C or Lp(a) throughout the intervention. Notably, mixed nut consumption lowered body fat percentage without significant changes in body weight or BMI. Future studies with larger sample sizes investigating the changing trends of CRP, 8-oxodG, and TAC are warranted.
CLINICAL TRIAL REGISTER
UNASSIGNED
NCT03375866.
Identifiants
pubmed: 37263914
pii: S0939-4753(23)00196-5
doi: 10.1016/j.numecd.2023.05.013
pii:
doi:
Substances chimiques
Cholesterol, LDL
0
Lipoprotein(a)
0
Adiponectin
0
8-Hydroxy-2'-Deoxyguanosine
88847-89-6
Banques de données
ClinicalTrials.gov
['NCT03375866']
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1529-1538Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors disclose no conflict of interest.