Plasmacytoid dendritic cells: A dendritic cell in disguise.
Antigen presentation
Plasmacytoid dendritic cells
Transitional dendritic cells
Type I interferon
Journal
Molecular immunology
ISSN: 1872-9142
Titre abrégé: Mol Immunol
Pays: England
ID NLM: 7905289
Informations de publication
Date de publication:
07 2023
07 2023
Historique:
received:
14
03
2023
accepted:
20
05
2023
medline:
13
6
2023
pubmed:
4
6
2023
entrez:
3
6
2023
Statut:
ppublish
Résumé
Since their discovery, the identity of plasmacytoid dendritic cells (pDCs) has been at the center of a continuous dispute in the field, and their classification as dendritic cells (DCs) has been recently re-challenged. pDCs are different enough from the rest of the DC family members to be considered a lineage of cells on their own. Unlike the exclusive myeloid ontogeny of cDCs, pDCs may have dual origin developing from myeloid and lymphoid progenitors. Moreover, pDCs have the unique ability to quickly secrete abundant levels of type I interferon (IFN-I) in response to viral infections. In addition, pDCs undergo a differentiation process after pathogen recognition that allows them to activate T cells, a feature that has been shown to be independent of presumed contaminating cells. Here, we aim to provide an overview of the historic and current understanding of pDCs and argue that their classification as either lymphoid or myeloid may be an oversimplification. Instead, we propose that the capacity of pDCs to link the innate and adaptive immune response by directly sensing pathogens and activating adaptive immune responses justify their inclusion within the DC network.
Identifiants
pubmed: 37269733
pii: S0161-5890(23)00102-5
doi: 10.1016/j.molimm.2023.05.007
pmc: PMC10625168
mid: NIHMS1924445
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
38-45Subventions
Organisme : NIAID NIH HHS
ID : R01 AI158808
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI163775
Pays : United States
Informations de copyright
Published by Elsevier Ltd.
Références
J Immunol. 2004 Aug 1;173(3):1535-48
pubmed: 15265881
Virchows Arch B Cell Pathol. 1973;14(1):47-56
pubmed: 4201009
Nature. 2006 Nov 2;444(7115):115-8
pubmed: 17051151
Nature. 1997 Aug 21;388(6644):782-7
pubmed: 9285591
Immunity. 2018 Apr 17;48(4):730-744.e5
pubmed: 29669251
Int Rev Cell Mol Biol. 2019;349:177-211
pubmed: 31759431
J Immunol. 2016 Mar 15;196(6):2561-71
pubmed: 26851220
Nat Immunol. 2014 Feb;15(2):161-7
pubmed: 24362890
Immunity. 2006 Dec;25(6):885-94
pubmed: 17174123
J Exp Med. 1997 Mar 17;185(6):1101-11
pubmed: 9091583
Immunity. 2019 Apr 16;50(4):1054-1068.e3
pubmed: 30926235
J Exp Med. 1997 Dec 15;186(12):2075-80
pubmed: 9396779
Nat Rev Immunol. 2023 Jan;23(1):1-2
pubmed: 36380022
Science. 2017 Jun 9;356(6342):
pubmed: 28473638
J Leukoc Biol. 1988 Apr;43(4):323-34
pubmed: 2832497
Sci Immunol. 2021 Apr 2;6(58):
pubmed: 33811059
Nat Methods. 2018 May;15(5):379-386
pubmed: 29630061
J Exp Med. 2007 Oct 29;204(11):2561-8
pubmed: 17923504
Nat Immunol. 2011 Jan;12(1):21-7
pubmed: 21113163
Nature. 1998 Mar 19;392(6673):245-52
pubmed: 9521319
J Immunol. 2010 Apr 15;184(8):4276-83
pubmed: 20304825
Blood. 2013 Jan 3;121(1):11-9
pubmed: 23053574
Blood. 2008 Apr 15;111(8):4245-53
pubmed: 18258799
Nat Immunol. 2004 Sep;5(9):899-908
pubmed: 15322541
J Leukoc Biol. 2005 May;77(5):689-98
pubmed: 15728242
Immunity. 2013 May 23;38(5):943-57
pubmed: 23623382
J Clin Invest. 2005 Feb;115(2):407-17
pubmed: 15668740
Annu Rev Immunol. 2004;22:307-28
pubmed: 15032580
Nat Immunol. 2011 Oct 19;12(11):1035-44
pubmed: 22012443
J Immunol. 2001 Feb 15;166(4):2291-5
pubmed: 11160284
Science. 2007 Jan 5;315(5808):107-11
pubmed: 17204652
Lancet. 1975 May 3;1(7914):1031-2
pubmed: 48698
Blood. 2005 Nov 1;106(9):3227-33
pubmed: 16020505
Cell Metab. 2016 May 10;23(5):852-66
pubmed: 27166946
Nat Rev Immunol. 2008 Aug;8(8):594-606
pubmed: 18641647
Immunity. 2004 Jul;21(1):43-53
pubmed: 15345219
Cell Mol Immunol. 2020 Jun;17(6):587-599
pubmed: 32433540
Hum Pathol. 1988 Sep;19(9):1085-92
pubmed: 3262083
Nat Immunol. 2008 Nov;9(11):1244-52
pubmed: 18849989
Kidney Int. 2018 Feb;93(2):355-364
pubmed: 29061332
Nat Immun Cell Growth Regul. 1985;4(3):120-37
pubmed: 2995798
Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3491-6
pubmed: 18305173
J Exp Med. 2000 Jul 17;192(2):219-26
pubmed: 10899908
Science. 2017 Apr 21;356(6335):
pubmed: 28428369
Cancer Immunol Immunother. 2012 Aug;61(8):1279-88
pubmed: 22294456
Sci Rep. 2016 Apr 26;6:25060
pubmed: 27112985
Nat Rev Immunol. 2015 Aug;15(8):471-85
pubmed: 26160613
Immunity. 2022 Mar 8;55(3):405-422.e11
pubmed: 35180378
Histopathology. 1983 Nov;7(6):825-39
pubmed: 6229466
Nat Commun. 2018 Aug 20;9(1):3317
pubmed: 30127440
Eur J Immunol. 1983 Jun;13(6):471-6
pubmed: 6574913
J Immunol. 2021 Feb 15;206(4):785-796
pubmed: 33441439
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14745-50
pubmed: 20679228
J Exp Med. 2003 Jul 21;198(2):305-13
pubmed: 12874263
Immunity. 2008 Sep 19;29(3):352-61
pubmed: 18799143
PLoS One. 2016 Feb 12;11(2):e0148753
pubmed: 26871568
Blood. 2006 Aug 1;108(3):878-85
pubmed: 16507769
Eur J Immunol. 2011 Apr;41(4):1014-23
pubmed: 21413003
Nat Immunol. 2007 Nov;8(11):1217-26
pubmed: 17922015
Immunol Rev. 2005 Oct;207:191-205
pubmed: 16181337
Immunity. 2012 Mar 23;36(3):438-50
pubmed: 22444632
J Exp Med. 2001 Aug 20;194(4):379-91
pubmed: 11514596
Science. 1999 Jun 11;284(5421):1835-7
pubmed: 10364556
Immunity. 2017 Dec 19;47(6):1037-1050.e6
pubmed: 29221729
J Exp Med. 2021 Apr 5;218(4):
pubmed: 33533916
EMBO J. 1997 May 15;16(10):2851-60
pubmed: 9184229
Genes Immun. 2011 Sep;12(6):399-414
pubmed: 21490621
J Exp Med. 2002 Mar 18;195(6):695-704
pubmed: 11901196
Crit Rev Immunol. 2012;32(6):463-88
pubmed: 23428224
Front Immunol. 2021 Apr 29;12:672729
pubmed: 33995415
Immunity. 2020 Aug 18;53(2):335-352.e8
pubmed: 32610077
Nat Immunol. 2000 Oct;1(4):305-10
pubmed: 11017101
Blood. 2006 Mar 15;107(6):2423-31
pubmed: 16293610
Nat Immunol. 2018 Jul;19(7):711-722
pubmed: 29925996
J Exp Med. 2004 Dec 6;200(11):1519-24
pubmed: 15557348
Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5598-603
pubmed: 15034168
J Exp Med. 2006 Jul 10;203(7):1629-35
pubmed: 16785312
Nat Immunol. 2019 Jul;20(7):852-864
pubmed: 31213723
Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12551-6
pubmed: 9356487
Nat Rev Immunol. 2023 May;23(5):336-337
pubmed: 36959479
Eur J Immunol. 2006 Sep;36(9):2286-92
pubmed: 16892183
Semin Immunol. 2009 Oct;21(5):265-72
pubmed: 19524453
Nat Immunol. 2020 Sep;21(9):983-997
pubmed: 32690951
Elife. 2014 Oct 13;3:
pubmed: 25310240
Cell Rep. 2019 Dec 10;29(11):3736-3750.e8
pubmed: 31825848
Clin Mol Allergy. 2021 Nov 17;19(1):23
pubmed: 34789269
Blood. 2003 May 1;101(9):3520-6
pubmed: 12511409
J Immunol. 2003 Sep 15;171(6):3296-302
pubmed: 12960360
J Exp Med. 2004 Feb 16;199(4):567-79
pubmed: 14970182
Immunity. 2010 Dec 14;33(6):905-16
pubmed: 21145760
Nat Immunol. 2008 Nov;9(11):1253-60
pubmed: 18836452
Nat Med. 1999 Aug;5(8):919-23
pubmed: 10426316
Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8122-E8130
pubmed: 27911806
Cell. 2008 Oct 3;135(1):37-48
pubmed: 18854153
J Exp Med. 2007 Jan 22;204(1):105-15
pubmed: 17200410
Nat Immunol. 2018 Jan;19(1):63-75
pubmed: 29203862
Immunity. 2007 Sep;27(3):481-92
pubmed: 17869134
Acta Haematol. 1958 Feb;19(2):99-113
pubmed: 13520253
Sci Rep. 2018 Jan 9;8(1):154
pubmed: 29317685
Eur J Immunol. 2013 Jul;43(7):1706-15
pubmed: 23553052
PLoS One. 2009 Sep 22;4(9):e7111
pubmed: 19771163
Cell Rep. 2020 Sep 22;32(12):108180
pubmed: 32966789
Nat Immunol. 2004 Dec;5(12):1227-34
pubmed: 15531885
Science. 1999 Feb 19;283(5405):1183-6
pubmed: 10024247
Immunity. 2019 Jan 15;50(1):37-50
pubmed: 30650380
J Exp Med. 1973 May 1;137(5):1142-62
pubmed: 4573839
Eur J Immunol. 1998 Feb;28(2):473-8
pubmed: 9521055
Nat Immunol. 2007 Nov;8(11):1207-16
pubmed: 17922016
Viruses. 2021 Sep 15;13(9):
pubmed: 34578420
Eur J Immunol. 2013 May;43(5):1264-73
pubmed: 23436642
Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1988-1993
pubmed: 28167780