Cell-type specific molecular architecture for mu opioid receptor function in pain and addiction circuits.
Cell types
Mu opioid receptor
Nervous system
Opioid addiction
Opioid analgesia
Single cell RNA-Sequencing
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
01 11 2023
01 11 2023
Historique:
received:
12
04
2023
accepted:
13
05
2023
pmc-release:
01
11
2024
medline:
7
8
2023
pubmed:
5
6
2023
entrez:
4
6
2023
Statut:
ppublish
Résumé
Opioids are potent analgesics broadly used for pain management; however, they can produce dangerous side effects including addiction and respiratory depression. These harmful effects have led to an epidemic of opioid abuse and overdose deaths, creating an urgent need for the development of both safer pain medications and treatments for opioid use disorders. Both the analgesic and addictive properties of opioids are mediated by the mu opioid receptor (MOR), making resolution of the cell types and neural circuits responsible for each of the effects of opioids a critical research goal. Single-cell RNA sequencing (scRNA-seq) technology is enabling the identification of MOR-expressing cell types throughout the nervous system, creating new opportunities for mapping distinct opioid effects onto newly discovered cell types. Here, we describe molecularly defined MOR-expressing neuronal cell types throughout the peripheral and central nervous systems and their potential contributions to opioid analgesia and addiction.
Identifiants
pubmed: 37271281
pii: S0028-3908(23)00187-9
doi: 10.1016/j.neuropharm.2023.109597
pmc: PMC10494323
mid: NIHMS1917837
pii:
doi:
Substances chimiques
Analgesics, Opioid
0
Receptors, Opioid, mu
0
Analgesics
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
109597Subventions
Organisme : NIDA NIH HHS
ID : R01 DA044481
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA054583
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA049241
Pays : United States
Organisme : NIDA NIH HHS
ID : F32 DA057779
Pays : United States
Organisme : NIDA NIH HHS
ID : F30 DA057839
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have no competiting interests to disclose.
Références
Neuroscience. 1991;43(1):197-209
pubmed: 1717884
Neuron. 2017 May 17;94(4):759-773.e8
pubmed: 28521131
Aging (Albany NY). 2019 Sep 12;11(17):6638-6656
pubmed: 31514171
Annu Rev Neurosci. 2018 Jul 8;41:453-473
pubmed: 29852083
Science. 2022 Apr;376(6588):86-90
pubmed: 35357926
Br J Pharmacol. 2020 May;177(10):2320-2332
pubmed: 31971607
Pain. 2020 Jul;161(7):1636-1649
pubmed: 32102022
Biol Psychiatry. 2017 May 1;81(9):778-788
pubmed: 28185645
Trends Neurosci. 2015 Nov;38(11):741-750
pubmed: 26603560
Elife. 2020 Jun 22;9:
pubmed: 32568072
Brain Res Mol Brain Res. 1998 Mar 1;54(2):321-6
pubmed: 9555078
Neuron. 2009 Mar 12;61(5):786-800
pubmed: 19285474
Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1544-9
pubmed: 9037090
Pharmaceuticals (Basel). 2021 Oct 27;14(11):
pubmed: 34832873
iScience. 2019 Apr 26;14:47-57
pubmed: 30925410
Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10811-6
pubmed: 19528663
Neuropsychopharmacology. 2011 Feb;36(3):589-602
pubmed: 21048703
Neuron. 2022 Aug 17;110(16):2664-2679.e8
pubmed: 35700737
J Neurosci. 2008 Dec 24;28(52):14007-17
pubmed: 19109484
J Neurosci. 2014 Sep 3;34(36):11929-47
pubmed: 25186741
Neuropharmacology. 2013 Dec;75:78-85
pubmed: 23891638
Arch Surg. 1988 Jan;123(1):66-7
pubmed: 3337659
Mol Psychiatry. 2021 Apr;26(4):1178-1193
pubmed: 31413370
Front Cell Neurosci. 2022 Aug 29;16:933874
pubmed: 36106013
FEBS Lett. 1994 Apr 18;343(1):42-6
pubmed: 8163014
Neuroscience. 1996 Dec;75(4):1231-8
pubmed: 8938756
Neuron. 2014 Jun 18;82(6):1346-56
pubmed: 24857021
Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):11078-11083
pubmed: 30297409
Pain. 2012 Oct;153(10):2017-2030
pubmed: 22703890
Neuron. 2011 Jan 13;69(1):6-8
pubmed: 21318174
J Comp Neurol. 1995 Apr 3;354(2):253-81
pubmed: 7782502
J Clin Invest. 2015 Oct 1;125(10):3782-94
pubmed: 26426077
Exp Neurobiol. 2018 Apr;27(2):120-128
pubmed: 29731678
Pharmacol Biochem Behav. 2021 Jan;200:173072
pubmed: 33227308
Cell. 2018 Aug 9;174(4):1015-1030.e16
pubmed: 30096299
Neuropsychopharmacology. 2020 Jan;45(2):247-255
pubmed: 31005059
Neuropharmacology. 2020 Jun 15;170:108052
pubmed: 32188569
Nat Neurosci. 2013 Feb;16(2):183-92
pubmed: 23292683
Cell Rep. 2018 Aug 21;24(8):2179-2190.e7
pubmed: 30134177
Brain. 2022 Jul 29;145(7):2586-2601
pubmed: 35598161
Nat Neurosci. 2018 Jun;21(6):869-880
pubmed: 29686262
Adv Pharmacol. 2018;82:261-291
pubmed: 29413524
Science. 1971 Dec 24;174(4016):1351-4
pubmed: 5167502
Nature. 2007 Jan 11;445(7124):168-76
pubmed: 17151600
eNeuro. 2020 May 29;7(3):
pubmed: 32381649
Mol Pharmacol. 2008 Oct;74(4):972-9
pubmed: 18612077
Curr Opin Neurobiol. 2004 Jun;14(3):370-8
pubmed: 15194118
Immunity. 2019 Jan 15;50(1):253-271.e6
pubmed: 30471926
J Neurosci. 2020 Nov 11;40(46):8853-8869
pubmed: 33046548
Glia. 2001 Oct;36(1):78-88
pubmed: 11571786
Neuroscience. 1994 Oct;62(3):829-41
pubmed: 7870310
Cell. 2018 Aug 9;174(4):999-1014.e22
pubmed: 30096314
J Physiol. 2019 Mar;597(6):1661-1675
pubmed: 30578671
Mol Neurodegener. 2020 May 7;15(1):28
pubmed: 32381088
Nature. 1980 Mar 27;284(5754):351-3
pubmed: 6244504
Neuron. 2019 May 8;102(3):529-552
pubmed: 31071288
Biol Psychiatry. 2015 Feb 1;77(3):236-245
pubmed: 25433903
Neuropsychopharmacology. 2001 Jul;25(1):41-54
pubmed: 11377918
Brain Res Rev. 2009 Apr;60(1):214-25
pubmed: 19146877
Cell. 2009 Jun 12;137(6):1148-59
pubmed: 19524516
Pharmacol Res. 2023 Apr;190:106734
pubmed: 36933754
Cell Rep. 2016 Jul 26;16(4):1126-1137
pubmed: 27425622
J Comp Neurol. 1994 Jul 1;345(1):46-68
pubmed: 8089277
Nature. 2019 Jun;570(7761):332-337
pubmed: 31042697
Neuropsychopharmacology. 2012 Apr;37(5):1164-76
pubmed: 22169942
Science. 1973 Mar 9;179(4077):1011-4
pubmed: 4687585
Neuron. 2019 Feb 20;101(4):748-761.e5
pubmed: 30638902
J Pharmacol Sci. 2008 Apr;106(4):667-70
pubmed: 18403901
Neuron. 1993 Nov;11(5):903-13
pubmed: 8240812
J Neurophysiol. 2005 Sep;94(3):1825-36
pubmed: 16105955
PLoS One. 2013 Sep 12;8(9):e74706
pubmed: 24069332
J Neurophysiol. 2020 Sep 1;124(3):790-801
pubmed: 32755331
Neuron. 2013 Nov 20;80(4):1039-53
pubmed: 24267654
Brain Res. 1985 Dec 16;359(1-2):131-9
pubmed: 4075141
Front Psychiatry. 2019 Jan 04;9:726
pubmed: 30662412
Neuropsychopharmacology. 2020 Jul;45(8):1251-1262
pubmed: 31747681
Neuroscience. 2014 Sep 26;277:595-609
pubmed: 25086313
Mol Pain. 2020 Jan-Dec;16:1744806920966144
pubmed: 33108956
Front Behav Neurosci. 2018 Oct 09;12:238
pubmed: 30356828
J Neurosci. 2003 May 15;23(10):4324-32
pubmed: 12764121
Elife. 2018 Oct 30;7:
pubmed: 30373717
Brain Res Mol Brain Res. 1995 Jun;30(2):203-10
pubmed: 7543648
Brain Res. 2020 Feb 15;1729:146623
pubmed: 31881186
Cell. 2021 Jun 10;184(12):3222-3241.e26
pubmed: 34004146
J Neurosci. 2008 Oct 22;28(43):11030-41
pubmed: 18945911
Cell Rep. 2022 Apr 5;39(1):110616
pubmed: 35385745
Nat Commun. 2022 Feb 9;13(1):764
pubmed: 35140231
Cell Rep. 2018 Feb 20;22(8):2216-2225
pubmed: 29466745
Neuron. 2015 Dec 16;88(6):1227-1239
pubmed: 26671460
Elife. 2019 May 17;8:
pubmed: 31099753
Science. 1974 Sep 20;185(4156):1055-7
pubmed: 4604871
Nature. 2020 Jan;577(7790):392-398
pubmed: 31915380
J Chem Neuroanat. 1995 May;8(4):283-305
pubmed: 7669273
J Neurosci Res. 2022 Jan;100(1):48-65
pubmed: 33957003
Nat Rev Neurosci. 2013 Jul;14(7):502-11
pubmed: 23719569
Pain. 1977 Oct;4(1):23-40
pubmed: 927879
Neuropharmacology. 2017 Sep 1;123:420-432
pubmed: 28645621
J Neurosci. 2015 Sep 16;35(37):12917-31
pubmed: 26377476
Sci Adv. 2020 Jun 24;6(26):eaba4221
pubmed: 32637607
Nature. 2021 Oct;598(7882):646-651
pubmed: 34646022
Elife. 2019 Apr 12;8:
pubmed: 30977723
Neurosci Biobehav Rev. 2021 Jan;120:417-430
pubmed: 33152423
J Neurosci. 2015 May 6;35(18):7264-71
pubmed: 25948274
Trends Neurosci. 2015 Apr;38(4):217-25
pubmed: 25637939
Science. 2002 Mar 1;295(5560):1737-40
pubmed: 11834781
Pain. 2006 May;122(1-2):63-7
pubmed: 16527398
Neuropsychopharmacology. 2016 Jul;41(8):2122-32
pubmed: 26792442
Brain Behav Immun. 2012 Mar;26(3):489-99
pubmed: 22281280
J Appl Physiol (1985). 2022 Jun 1;132(6):1407-1422
pubmed: 35421320
Prog Brain Res. 2000;122:245-53
pubmed: 10737063
Brain Res. 1979 Jul 6;170(1):95-111
pubmed: 223722
Neuropharmacology. 1993 Dec;32(12):1299-303
pubmed: 8152521
Neuropsychopharmacology. 2021 Oct;46(11):1990-1999
pubmed: 34341495
Transl Psychiatry. 2023 Mar 3;13(1):78
pubmed: 36869037
Nat Rev Neurosci. 2018 Aug;19(8):499-514
pubmed: 29934561
Pain. 2018 Dec;159(12):2512-2521
pubmed: 30086115
Nat Commun. 2017 Mar 22;8:14611
pubmed: 28327612
J Neurosci. 2002 Dec 15;22(24):10847-55
pubmed: 12486178
Neuroreport. 1993 Dec 13;5(3):341-4
pubmed: 8298100
J Comp Neurol. 1994 Dec 15;350(3):412-38
pubmed: 7884049
Biol Psychiatry. 2023 Jun 15;93(12):1108-1117
pubmed: 36496267
Pain. 2020 Jul;161(7):1497-1517
pubmed: 32197039
Handb Behav Neurosci. 2020;26:101-113
pubmed: 33889063
J Neurosci. 1997 Apr 1;17(7):2585-94
pubmed: 9065518
Int J Neuropharmacol. 1966 Jan;5(1):35-42
pubmed: 5913738
Regul Pept. 2002 Dec 31;110(1):75-83
pubmed: 12468112
Psychopharmacology (Berl). 2013 Dec;230(4):525-35
pubmed: 23793269
Nat Med. 2017 Feb;23(2):164-173
pubmed: 28092666
Handb Exp Pharmacol. 2018;247:87-114
pubmed: 28993838
Commun Biol. 2021 Sep 14;4(1):1070
pubmed: 34522000
Sci Rep. 2019 Nov 28;9(1):17837
pubmed: 31780740
J Neurosci. 1983 Dec;3(12):2545-52
pubmed: 6317812
Elife. 2022 Nov 01;11:
pubmed: 36317965
Neurosci Lett. 1995 Jan 30;184(3):149-52
pubmed: 7715834
Harm Reduct J. 2018 Dec 22;15(1):64
pubmed: 30577844
Neuron. 2020 Oct 14;108(1):128-144.e9
pubmed: 32810432
Neuroscience. 2004;129(3):841-7
pubmed: 15541905
Neurosci Res. 1994 Jan;18(4):315-22
pubmed: 8190373
Neurosci Bull. 2020 Oct;36(10):1095-1106
pubmed: 32451910
Proc Natl Acad Sci U S A. 1976 Oct;73(10):3729-33
pubmed: 185626
Nat Rev Neurosci. 2010 Dec;11(12):823-36
pubmed: 21068766
Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10230-4
pubmed: 8234282
Ann N Y Acad Sci. 2013 Apr;1282:1-11
pubmed: 23496247
Neuron. 2021 Apr 21;109(8):1365-1380.e5
pubmed: 33740416
Nat Neurosci. 2016 Feb;19(2):335-46
pubmed: 26727548
Neuron. 2018 Jun 6;98(5):963-976.e5
pubmed: 29754753
eNeuro. 2020 Sep 21;7(5):
pubmed: 32859725
Neuron. 2020 Sep 23;107(6):1113-1123.e4
pubmed: 32679036
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14857-62
pubmed: 20682748
Peptides. 1983 Sep-Oct;4(5):603-8
pubmed: 6657509
FEBS Lett. 1994 Jan 31;338(2):217-22
pubmed: 7905839
J Neurosci. 2017 Oct 18;37(42):10154-10172
pubmed: 28924009
Nat Neurosci. 2021 Dec;24(12):1757-1771
pubmed: 34663959
Science. 2019 Jan 18;363(6424):276-281
pubmed: 30655440
Neuron. 2017 Feb 22;93(4):822-839.e6
pubmed: 28162807
Neuron. 2014 Mar 19;81(6):1443
pubmed: 28898633
Neuron. 2018 Apr 4;98(1):90-108.e5
pubmed: 29576387
Brain Res. 1977 Mar 18;124(1):53-67
pubmed: 191149
Science. 1973 Nov 2;182(4111):490-2
pubmed: 4582903
Pain. 2020 Mar;161(3):609-618
pubmed: 31725062
Front Mol Neurosci. 2022 Jun 15;15:919773
pubmed: 35782382
Science. 1976 Jun 25;192(4246):1357-8
pubmed: 1273597
Science. 2001 Jul 13;293(5528):311-5
pubmed: 11452128
Cell. 2005 Aug 26;122(4):619-31
pubmed: 16122428
Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):
pubmed: 34074761
Cell Rep. 2019 Dec 24;29(13):4320-4333.e5
pubmed: 31875543
Addict Biol. 2021 May;26(3):e12942
pubmed: 32686251
Pain. 2023 Apr 1;164(4):703-716
pubmed: 35973045
J Neurosci. 2011 Nov 30;31(48):17729-35
pubmed: 22131433
Neuron. 2022 Mar 2;110(5):857-873.e9
pubmed: 34921781
Pain. 2016 Jan;157(1):166-173
pubmed: 26335909
Neuropharmacology. 1970 Nov;9(6):539-51
pubmed: 5537123
Pharmacol Biochem Behav. 1981 Mar;14(3):325-31
pubmed: 7232458
Front Pharmacol. 2020 Jul 15;11:1078
pubmed: 32760281
Trends Neurosci. 1995 Jan;18(1):22-9
pubmed: 7535487
J Neurosci. 1995 May;15(5 Pt 1):3328-41
pubmed: 7751913
Eur J Pharmacol. 1987 Jan 28;134(1):53-9
pubmed: 3030781
J Neurosci. 1996 Jul 1;16(13):4162-73
pubmed: 8753878
Trends Neurosci. 2012 Nov;35(11):681-90
pubmed: 22824232
Nature. 1996 Oct 31;383(6603):819-23
pubmed: 8893006
Elife. 2019 Aug 14;8:
pubmed: 31411560
Neuron. 2020 May 6;106(3):498-514.e8
pubmed: 32145184
eNeuro. 2018 Feb 6;5(1):
pubmed: 29445764
Exp Neurol. 2004 Jul;188(1):139-48
pubmed: 15191810
Front Synaptic Neurosci. 2021 Dec 14;13:799274
pubmed: 34970134
Genesis. 2020 Jan;58(1):e23341
pubmed: 31651080
Nat Neurosci. 2014 Feb;17(2):254-61
pubmed: 24413699
Prog Neuropsychopharmacol Biol Psychiatry. 2000 Aug;24(6):993-1006
pubmed: 11041539
Brain Res. 1976 Sep 10;114(1):83-103
pubmed: 963546
Exp Neurol. 2006 Jan;197(1):22-30
pubmed: 15996657
Sci Transl Med. 2021 Nov 10;13(619):eabj7360
pubmed: 34757810
Nature. 2016 Feb 11;530(7589):219-22
pubmed: 26840481
Mol Neurodegener. 2018 Jun 28;13(1):34
pubmed: 29954413
Neuroreport. 1995 Mar 27;6(5):725-9
pubmed: 7605935
Front Syst Neurosci. 2022 Aug 15;16:963812
pubmed: 36045708
J Neurochem. 2004 Nov;91(4):881-90
pubmed: 15525342
Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9241-6
pubmed: 8799185
J Neurosci. 2022 Mar 9;42(10):2011-2024
pubmed: 35031576
Neuron. 2020 Sep 9;107(5):864-873.e4
pubmed: 32610039
Nature. 1973 Oct 26;245(5426):447-50
pubmed: 4127185
Br J Pharmacol. 2020 Mar;177(5):1187-1205
pubmed: 31655493
Neurosci Lett. 2019 May 29;702:15-23
pubmed: 30503916
Nat Neurosci. 2015 Jan;18(1):145-53
pubmed: 25420068
Brain Struct Funct. 2015 Mar;220(2):677-702
pubmed: 24623156
Science. 1977 Nov 25;198(4319):842-5
pubmed: 199942
Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):E1738-46
pubmed: 26884166
Neuroscience. 2000;98(2):221-31
pubmed: 10854753
Pain. 2010 Sep;150(3):401-413
pubmed: 20573450
J Neurosci. 2000 Jun 1;20(11):4345-54
pubmed: 10818170
Neuropharmacology. 2020 Aug 15;173:108131
pubmed: 32422213
J Comp Neurol. 1996 Apr 08;367(3):375-402
pubmed: 8698899
Neurochem Res. 1996 Nov;21(11):1315-31
pubmed: 8947922
J Neurosci. 2014 Oct 29;34(44):14707-16
pubmed: 25355223
iScience. 2022 Nov 04;25(12):105497
pubmed: 36425768
Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16446-50
pubmed: 21930931
J Pharmacol Exp Ther. 1965 Oct;150(1):135-9
pubmed: 5322549
J Neurosci Res. 2022 Jan;100(1):66-98
pubmed: 33314372
Neuropsychopharmacology. 2018 Dec;43(13):2514-2520
pubmed: 30250308
J Neurosci. 2011 Jul 13;31(28):10119-27
pubmed: 21752988
Nat Neurosci. 2019 Nov;22(11):1925-1935
pubmed: 31527803
Pain. 2011 Jun;152(6):1238-1248
pubmed: 21295407
Mol Cells. 2016 Sep;39(9):645-53
pubmed: 27506251
Science. 2020 Mar 6;367(6482):
pubmed: 32139519
Eur J Neurosci. 2002 Apr;15(8):1306-16
pubmed: 11994125
Pain Res Manag. 2017;2017:8296501
pubmed: 29302197
Neuroscience. 1999;88(4):1093-135
pubmed: 10336124
Int Rev Neurobiol. 2021;157:31-68
pubmed: 33648672
Pharmacol Biochem Behav. 1980 Jun;12(6):965-8
pubmed: 7403209
J Neurosci. 2019 Oct 16;39(42):8225-8230
pubmed: 31619491
Nature. 2012 Nov 8;491(7423):212-7
pubmed: 23064228
Neuron. 2016 Sep 7;91(5):1069-1084
pubmed: 27568516
Elife. 2020 Jun 10;9:
pubmed: 32519950
Neuroreport. 2012 Apr 18;23(6):378-84
pubmed: 22362187
Trends Neurosci. 2018 May;41(5):280-293
pubmed: 29703377
Nat Commun. 2021 Sep 29;12(1):5722
pubmed: 34588430
Neuroscience. 2015 Aug 20;301:529-41
pubmed: 26116518
Neuron. 2009 Aug 27;63(4):533-43
pubmed: 19709634
Neuropharmacology. 2014 Jan;76 Pt B:204-17
pubmed: 24035914
J Neurochem. 2017 Aug;142 Suppl 2:130-143
pubmed: 28791703
J Pharmacol Exp Ther. 1967 Jul;157(1):185-95
pubmed: 6029484
PLoS One. 2022 Dec 19;17(12):e0270317
pubmed: 36534642