Assay discrepancies using human coagulation factor VIII chromogenic kits: Results from a plasma-derived factor VIII collaborative study (BSP112).
BSP
Biological Standardisation Programme
FVIII assay discrepancy
FX activation
Factor VIII
chromogenic kit
Journal
Pharmeuropa bio & scientific notes
ISSN: 2075-2504
Titre abrégé: Pharmeur Bio Sci Notes
Pays: France
ID NLM: 101510163
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
6
6
2023
pubmed:
5
6
2023
entrez:
5
6
2023
Statut:
ppublish
Résumé
Chromogenic assay discrepancies were reported at General European Official Medicines Control Laboratories Network (GEON) meetings by laboratories testing FVIII-products. The objectives of the present investigation were to carry out a controlled collaborative study to examine these reports and to delineate the reasons for these discrepancies by assessing affected and unaffected FVIII products. The laboratories followed a strict study protocol, which included assessing their own individual observed factor X (FX) activation times, i.e. the time to reach 50% of maximal FX activation (T
Substances chimiques
Factor VIII
9001-27-8
Chromogenic Compounds
0
Hemostatics
0
Factor X
9001-29-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-14Informations de copyright
© Council of Europe, 2023.