Structural basis of a bi-functional malonyl-CoA reductase (MCR) from the photosynthetic green non-sulfur bacterium
3-hydroxypropionate
Roseiflexus castenholzii
bi-functional enzyme
malonyl-CoA reductase
short-chain dehydrogenase/reductase
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
31 08 2023
31 08 2023
Historique:
medline:
4
9
2023
pubmed:
6
6
2023
entrez:
6
6
2023
Statut:
ppublish
Résumé
Malonyl-CoA reductase (MCR) is a NADPH-dependent bi-functional enzyme that performs alcohol dehydrogenase and aldehyde dehydrogenase (CoA-acylating) activities in the N- and C-terminal fragments, respectively. It catalyzes the two-step reduction of malonyl-CoA to 3-hydroxypropionate (3-HP), a key reaction in the autotrophic CO
Identifiants
pubmed: 37278533
doi: 10.1128/mbio.03233-22
pmc: PMC10470521
doi:
Substances chimiques
malonyl-Coa reductase
EC 1.-
Alcohol Dehydrogenase
EC 1.1.1.1
NADP
53-59-8
Oxidoreductases
EC 1.-
Aldehyde Dehydrogenase
EC 1.2.1.3
Malonyl Coenzyme A
524-14-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0323322Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Acta Crystallogr D Biol Crystallogr. 1994 Sep 1;50(Pt 5):760-3
pubmed: 15299374
Protein Eng. 1999 Oct;12(10):851-6
pubmed: 10556245
J Chem Theory Comput. 2015 Aug 11;11(8):3696-713
pubmed: 26574453
Crit Rev Biotechnol. 2017 Nov;37(7):933-941
pubmed: 28078904
Protein Sci. 2021 Jan;30(1):70-82
pubmed: 32881101
Eur J Biochem. 1993 Aug 1;215(3):633-43
pubmed: 8354269
Environ Microbiol. 2020 Feb;22(2):752-765
pubmed: 31814251
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21
pubmed: 20124702
Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21317-22
pubmed: 19955419
Bioresour Technol. 2016 Jan;200:897-904
pubmed: 26606325
Acc Chem Res. 2000 Dec;33(12):889-97
pubmed: 11123888
Science. 2007 Dec 14;318(5857):1782-6
pubmed: 18079405
J Struct Biol. 2007 Jan;157(1):281-7
pubmed: 16963278
J Struct Biol. 2012 Dec;180(3):519-30
pubmed: 23000701
J Comput Chem. 2005 Dec;26(16):1668-88
pubmed: 16200636
J Comput Chem. 2004 Jul 15;25(9):1157-74
pubmed: 15116359
Biophys J. 2000 Mar;78(3):1606-19
pubmed: 10692345
Nat Methods. 2014 Jan;11(1):63-5
pubmed: 24213166
Molecules. 2019 Apr 21;24(8):
pubmed: 31010072
Biopolymers. 1999 Oct 5;50(4):373-80
pubmed: 10423546
J Biosci Bioeng. 2017 Oct;124(4):392-399
pubmed: 28522285
J Struct Biol. 2015 Nov;192(2):216-21
pubmed: 26278980
Nat Methods. 2017 Mar;14(3):290-296
pubmed: 28165473
J Bacteriol. 2010 Aug;192(16):4089-102
pubmed: 20400551
Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):240-55
pubmed: 15299926
Acta Crystallogr D Biol Crystallogr. 1999 Jan;55(Pt 1):191-205
pubmed: 10089410
Protein Eng. 1999 Feb;12(2):85-94
pubmed: 10195279
PLoS One. 2013 Sep 20;8(9):e75554
pubmed: 24073271
Metab Eng. 2016 Mar;34:104-111
pubmed: 26791242
J Biotechnol. 2012 Feb 20;157(4):633-40
pubmed: 21723339
Expert Opin Drug Discov. 2015 May;10(5):449-61
pubmed: 25835573
J Mol Graph Model. 2022 Jan;110:108058
pubmed: 34736054
J Bacteriol. 2003 Feb;185(3):938-47
pubmed: 12533469
J Struct Biol. 2005 Oct;152(1):36-51
pubmed: 16182563
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32
pubmed: 15572765
J Bacteriol. 2002 May;184(9):2404-10
pubmed: 11948153
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32
pubmed: 20124692
Int J Syst Evol Microbiol. 2002 Jan;52(Pt 1):187-193
pubmed: 11837302
Metab Eng. 2016 Mar;34:60-70
pubmed: 26546088
Arch Microbiol. 1974;100(1):5-24
pubmed: 4374148
J Chem Inf Model. 2018 Aug 27;58(8):1652-1661
pubmed: 29993249
Nat Methods. 2017 Apr;14(4):331-332
pubmed: 28250466
J Appl Crystallogr. 2007 Aug 1;40(Pt 4):658-674
pubmed: 19461840
Ann Rev Mar Sci. 2011;3:261-89
pubmed: 21329206
Metab Eng. 2020 May;59:142-150
pubmed: 32061966
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4226-30
pubmed: 7027257
J Mol Biol. 1968 Apr 28;33(2):491-7
pubmed: 5700707