Asthma symptoms, spirometry and air pollution exposure in schoolchildren in an informal settlement and an affluent area of Nairobi, Kenya.
asthma
asthma epidemiology
paediatric asthma
Journal
Thorax
ISSN: 1468-3296
Titre abrégé: Thorax
Pays: England
ID NLM: 0417353
Informations de publication
Date de publication:
11 2023
11 2023
Historique:
received:
23
01
2023
accepted:
03
05
2023
medline:
23
10
2023
pubmed:
7
6
2023
entrez:
6
6
2023
Statut:
ppublish
Résumé
Although 1 billion people live in informal (slum) settlements, the consequences for respiratory health of living in these settlements remain largely unknown. This study investigated whether children living in an informal settlement in Nairobi, Kenya are at increased risk of asthma symptoms. Children attending schools in Mukuru (an informal settlement in Nairobi) and a more affluent area (Buruburu) were compared. Questionnaires quantified respiratory symptoms and environmental exposures; spirometry was performed; personal exposure to particulate matter (PM 2373 children participated, 1277 in Mukuru (median age, IQR 11, 9-13 years, 53% girls), and 1096 in Buruburu (10, 8-12 years, 52% girls). Mukuru schoolchildren were from less affluent homes, had greater exposure to pollution sources and PM Children living in informal settlements are more likely to develop wheezing symptoms consistent with asthma that are more severe but less likely to be diagnosed as asthma. Self-reported but not objectively measured air pollution exposure was associated with increased risk of asthma symptoms.
Sections du résumé
BACKGROUND
Although 1 billion people live in informal (slum) settlements, the consequences for respiratory health of living in these settlements remain largely unknown. This study investigated whether children living in an informal settlement in Nairobi, Kenya are at increased risk of asthma symptoms.
METHODS
Children attending schools in Mukuru (an informal settlement in Nairobi) and a more affluent area (Buruburu) were compared. Questionnaires quantified respiratory symptoms and environmental exposures; spirometry was performed; personal exposure to particulate matter (PM
RESULTS
2373 children participated, 1277 in Mukuru (median age, IQR 11, 9-13 years, 53% girls), and 1096 in Buruburu (10, 8-12 years, 52% girls). Mukuru schoolchildren were from less affluent homes, had greater exposure to pollution sources and PM
CONCLUSION
Children living in informal settlements are more likely to develop wheezing symptoms consistent with asthma that are more severe but less likely to be diagnosed as asthma. Self-reported but not objectively measured air pollution exposure was associated with increased risk of asthma symptoms.
Identifiants
pubmed: 37280096
pii: thorax-2023-220057
doi: 10.1136/thorax-2023-220057
pmc: PMC10715514
doi:
Substances chimiques
Air Pollutants
0
Particulate Matter
0
Gases
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1118-1125Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S009027/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 218935/Z/19/Z
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: RD has declared employment by the University of Stirling for the duration of the study. ML has declared employment by the Institute of Occupational Medicine and funding for the study from UKRI MRC/Kenya National Research Fund. JKQ has declared personal funding from GlaxoSmithKline, Boehringer Ingelheim, AstraZeneca, Chiesi, Teva, Insmed, Bayer and institutional funding from UKRI MRC, Health Data Research UK, GlaxoSmithKline, Bayer, Boehringer Ingelheim, Chiesi, AstraZeneca and Asthma and Lung UK. All other authors have declared they have nothing to disclose.
Références
Thorax. 2014 Sep;69(9):805-10
pubmed: 24646659
Lancet. 2017 Feb 4;389(10068):547-558
pubmed: 27760703
Eur Respir Rev. 2015 Mar;24(135):92-101
pubmed: 25726560
Lancet Child Adolesc Health. 2017 Oct;1(2):114-123
pubmed: 29034296
Int J Environ Res Public Health. 2018 Jul 31;15(8):
pubmed: 30065166
Thorax. 1998 Nov;53(11):919-26
pubmed: 10193388
Environ Res. 2020 Jul;186:109606
pubmed: 32371276
Lancet. 2021 Mar 6;397(10277):928-940
pubmed: 33631128
Ann Trop Paediatr. 1994;14(1):15-9
pubmed: 7516128
Eur Respir J. 2012 Dec;40(6):1324-43
pubmed: 22743675
PLoS One. 2011 Jan 18;6(1):e16085
pubmed: 21267459
Dev World Bioeth. 2018 Dec;18(4):406-419
pubmed: 28816023
Emerg Themes Epidemiol. 2015 Sep 22;12:13
pubmed: 26396585
BMC Public Health. 2007 Aug 13;7:205
pubmed: 17697314
Environ Health. 2008 Dec 04;7:62
pubmed: 19055819
Chest. 2019 Feb;155(2):331-341
pubmed: 30359613
Int J Epidemiol. 1991 Mar;20(1):144-50
pubmed: 2066213
Afr Health Sci. 2018 Dec;18(4):965-971
pubmed: 30766561
Eur Respir J. 2022 Sep 15;60(3):
pubmed: 35210319
Environ Res. 2004 Oct;96(2):219-27
pubmed: 15325882
Eur Respir J. 2017 Jan 11;49(1):
pubmed: 28077477
Thorax. 2009 Jun;64(6):476-83
pubmed: 19237391
Clin Transl Allergy. 2014 Aug 04;4:24
pubmed: 25136441
Curr Opin Allergy Clin Immunol. 2012 Apr;12(2):171-8
pubmed: 22391754
Am J Respir Crit Care Med. 2016 Jan 1;193(1):23-30
pubmed: 26351837
Am J Respir Crit Care Med. 2019 Oct 15;200(8):e70-e88
pubmed: 31613151