Deferoxamine Promotes Peripheral Nerve Regeneration by Enhancing Schwann Cell Function and Promoting Axon Regeneration of Dorsal Root Ganglion.

Humans Nerve Regeneration / physiology Ganglia, Spinal Axons Deferoxamine / metabolism Cells, Cultured Schwann Cells / metabolism Nerve Growth Factors / metabolism Peripheral Nerve Injuries / metabolism
Schwann cells axon regeneration cell function deferoxamine dorsal root ganglion peripheral nerve regeneration

Journal

Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074

Informations de publication

Date de publication:
01 08 2023
Historique:
received: 26 11 2022
revised: 13 05 2023
accepted: 27 05 2023
medline: 26 7 2023
pubmed: 8 6 2023
entrez: 7 6 2023
Statut: ppublish

Résumé

Deferoxamine (DFO) is a potent iron chelator for clinical treatment of various diseases. Recent studies have also shown its potential to promote vascular regeneration during peripheral nerve regeneration. However, the effect of DFO on the Schwann cell function and axon regeneration remains unclear. In this study, we investigated the effects of different concentrations of DFO on Schwann cell viability, proliferation, migration, expression of key functional genes, and axon regeneration of dorsal root ganglia (DRG) through a series of in vitro experiments. We found that DFO improves Schwann cell viability, proliferation, and migration in the early stages, with an optimal concentration of 25 μM. DFO also upregulates the expression of myelin-related genes and nerve growth-promoting factors in Schwann cells, while inhibiting the expression of Schwann cell dedifferentiation genes. Moreover, the appropriate concentration of DFO promotes axon regeneration in DRG. Our findings demonstrate that DFO, with suitable concentration and duration of action, can positively affect multiple stages of peripheral nerve regeneration, thereby improving the effectiveness of nerve injury repair. This study also enriches the theory of DFO promoting peripheral nerve regeneration and provides a basis for the design of sustained-release DFO nerve grafts.

Identifiants

DOI: 10.1016/j.neuroscience.2023.05.029 PMID: 37286159
pubmed: 37286159
pii: S0306-4522(23)00249-X
doi: 10.1016/j.neuroscience.2023.05.029
pii:
doi:

Substances chimiques

Deferoxamine J06Y7MXW4D
Nerve Growth Factors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

149-157

Informations de copyright

Copyright © 2023 IBRO. Published by Elsevier Ltd. All rights reserved.

Auteurs

Tieyuan Zhang (T)

Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Department of Orthopedics, the Fourth Medical Center, Chinese PLA General Hospital, Beijing 100048, China; Medical School of Chinese PLA, Beijing 100853, China.

Jinjuan Zhao (J)

Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Department of Orthopedics, the Fourth Medical Center, Chinese PLA General Hospital, Beijing 100048, China.

Yanjun Guan (Y)

Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Department of Orthopedics, the Fourth Medical Center, Chinese PLA General Hospital, Beijing 100048, China; Medical School of Chinese PLA, Beijing 100853, China.

Xiangling Li (X)

Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Department of Orthopedics, the Fourth Medical Center, Chinese PLA General Hospital, Beijing 100048, China; The School of Medicine, Jinzhou Medical University, Jinzhou 121099, China.

Jun Bai (J)

Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Department of Orthopedics, the Fourth Medical Center, Chinese PLA General Hospital, Beijing 100048, China; Medical School of Chinese PLA, Beijing 100853, China.

Xiangyu Song (X)

Hebei North University, Zhangjiakou 075000, China.

Zhibo Jia (Z)

Hebei North University, Zhangjiakou 075000, China.

Shengfeng Chen (S)

Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Department of Orthopedics, the Fourth Medical Center, Chinese PLA General Hospital, Beijing 100048, China; Guizhou Medical University, Guiyang 550025, China.

Chaochao Li (C)

Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Department of Orthopedics, the Fourth Medical Center, Chinese PLA General Hospital, Beijing 100048, China; Medical School of Chinese PLA, Beijing 100853, China.

Yifan Xu (Y)

Medical School of Chinese PLA, Beijing 100853, China.

Jiang Peng (J)

Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Department of Orthopedics, the Fourth Medical Center, Chinese PLA General Hospital, Beijing 100048, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226007, China.

Yu Wang (Y)

Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma and War Injuries PLA, Department of Orthopedics, the Fourth Medical Center, Chinese PLA General Hospital, Beijing 100048, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226007, China. Electronic address: wangwangdian628@126.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Deferoxamine Promotes Peripheral Nerve...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Régénération nerveuse › Deferoxamine Promotes Peripheral Nerve...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Nerfs spinaux › Racines des nerfs spinaux › Ganglions sensitifs des nerfs spinaux › Deferoxamine Promotes Peripheral Nerve...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Deferoxamine Promotes Peripheral Nerve...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Acides hydroxamiques › Déferoxamine › Deferoxamine Promotes Peripheral Nerve...
questionsmedicales.fr › Cellules › Cellules cultivées › Deferoxamine Promotes Peripheral Nerve...
questionsmedicales.fr › Cellules › Névroglie › Cellules de Schwann › Deferoxamine Promotes Peripheral Nerve...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Deferoxamine Promotes Peripheral Nerve...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Lésions des nerfs périphériques › Deferoxamine Promotes Peripheral Nerve...