Epigenetic dysregulation from chromosomal transit in micronuclei.

Animals Humans Mice Chromatin / genetics Chromosomal Instability / genetics Chromosomes / genetics Epigenesis, Genetic Histones / chemistry Neoplasms / genetics Micronuclei, Chromosome-Defective Chromosome Segregation Mitosis DNA Copy Number Variations Protein Processing, Post-Translational

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
Jul 2023
Historique:
received: 15 11 2021
accepted: 14 04 2023
medline: 7 7 2023
pubmed: 8 6 2023
entrez: 7 6 2023
Statut: ppublish

Résumé

Chromosomal instability (CIN) and epigenetic alterations are characteristics of advanced and metastatic cancers

Identifiants

DOI: 10.1038/s41586-023-06084-7 PMID: 37286593 PMC: PMC10322720
pubmed: 37286593
doi: 10.1038/s41586-023-06084-7
pii: 10.1038/s41586-023-06084-7
pmc: PMC10322720
doi:

Substances chimiques

Chromatin 0
Histones 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

176-183

Subventions

Organisme : NCI NIH HHS
ID : T32 CA009207
Pays : United States
Organisme : NIH HHS
ID : DP5 OD026395
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA192937
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA261183
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM138386
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM114362
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA256188
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA270102
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA264379
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA247749
Pays : United States
Organisme : NIH HHS
ID : S10 OD030286
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016359
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007739
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA212290
Pays : United States
Organisme : NIMHD NIH HHS
ID : L32 MD017781
Pays : United States

Informations de copyright

© 2023. The Author(s).

Références

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Auteurs

Albert S Agustinus (AS)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Pharmacology Graduate Program, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-2700-6475

Duaa Al-Rawi (D)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-9218-6513

Bhargavi Dameracharla (B)

Department of Computer Science, University of California, San Diego, La Jolla, CA, USA.

Ramya Raviram (R)

New York Genome Center, New York, NY, USA.

Bailey S C L Jones (BSCL)

Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT, USA.
ORCID: 0000-0003-0007-2074

Stephanie Stransky (S)

Department of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.
ORCID: 0000-0003-0844-2754

Lorenzo Scipioni (L)

School of Engineering, University of California, Irvine, Irvine, CA, USA.
ORCID: 0000-0003-2980-1912

Jens Luebeck (J)

Department of Computer Science, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0003-4391-979X

Melody Di Bona (M)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-8853-2604

Danguole Norkunaite (D)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Robert M Myers (RM)

New York Genome Center, New York, NY, USA.
Tri-institutional MD-PhD Program, New York, NY, USA.
ORCID: 0000-0003-1869-6467

Mercedes Duran (M)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Seongmin Choi (S)

Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Britta Weigelt (B)

Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0001-9927-1270

Shira Yomtoubian (S)

Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA.

Andrew McPherson (A)

Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Eléonore Toufektchan (E)

Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Kristina Keuper (K)

Department of Molecular Genetics, University of Kaiserslautern, Kaiserslautern, Germany.
ORCID: 0000-0002-9841-5516

Paul S Mischel (PS)

Department of Pathology, School of Medicine, Stanford University, Stanford, CA, USA.
ORCID: 0000-0002-4560-2211

Vivek Mittal (V)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-4764-7413

Sohrab P Shah (SP)

Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0001-6402-523X

John Maciejowski (J)

Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0001-8134-9308

Zuzana Storchova (Z)

Department of Molecular Genetics, University of Kaiserslautern, Kaiserslautern, Germany.
ORCID: 0000-0003-2376-7047

Enrico Gratton (E)

School of Engineering, University of California, Irvine, Irvine, CA, USA.

Peter Ly (P)

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
ORCID: 0000-0001-8946-7069

Dan Landau (D)

New York Genome Center, New York, NY, USA.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

Mathieu F Bakhoum (MF)

Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT, USA.
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Yale Cancer Center, Yale University, New Haven, CT, USA.

Richard P Koche (RP)

Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-6820-5083

Simone Sidoli (S)

Department of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.
ORCID: 0000-0001-9073-6641

Vineet Bafna (V)

Department of Computer Science, University of California, San Diego, La Jolla, CA, USA.
ORCID: 0000-0002-5810-6241

Yael David (Y)

Pharmacology Graduate Program, Weill Cornell Medicine, New York, NY, USA. davidshy@mskcc.org.
Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. davidshy@mskcc.org.
Tri-institutional PhD Program in Chemical Biology, New York, NY, USA. davidshy@mskcc.org.
ORCID: 0000-0003-1696-0025

Samuel F Bakhoum (SF)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. samuel.bakhoum@gmail.com.
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. samuel.bakhoum@gmail.com.
ORCID: 0000-0002-4779-8422

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Epigenetic dysregulation from chromosomal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Epigenetic dysregulation from chromosomal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Epigenetic dysregulation from chromosomal...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Epigenetic dysregulation from chromosomal...
questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › Instabilité des chromosomes › Epigenetic dysregulation from chromosomal...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Epigenetic dysregulation from chromosomal...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Epigenetic dysregulation from chromosomal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Epigenetic dysregulation from chromosomal...
questionsmedicales.fr › Tumeurs › Epigenetic dysregulation from chromosomal...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Aberrations des chromosomes › Micronoyaux à chromosomes défectueux › Epigenetic dysregulation from chromosomal...
questionsmedicales.fr › Phénomènes génétiques › Division du noyau cellulaire › Ségrégation des chromosomes › Epigenetic dysregulation from chromosomal...
questionsmedicales.fr › Phénomènes génétiques › Division du noyau cellulaire › Mitose › Epigenetic dysregulation from chromosomal...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Variation structurale du génome › Variations de nombre de copies de segment d'ADN › Epigenetic dysregulation from chromosomal...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Epigenetic dysregulation from chromosomal...