Osteoporosis medication adherence tools: a systematic review.
Medication adherence
Medication persistence
Osteoporosis
Patient compliance
Journal
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
ISSN: 1433-2965
Titre abrégé: Osteoporos Int
Pays: England
ID NLM: 9100105
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
30
07
2022
accepted:
09
05
2023
medline:
16
8
2023
pubmed:
8
6
2023
entrez:
7
6
2023
Statut:
ppublish
Résumé
Poor adherence reduces the effectiveness of osteoporosis treatment, resulting in lower bone mineral density and subsequently higher fracture rates. Reliable and practical tools are needed to measure medication adherence. The aim of this systematic review was to find osteoporosis medication adherence measurement tools and assess their applicability. Osteoporosis adherence measurement tools and all their related keywords in PubMed, Embase, Web of Science, and Scopus databases were searched on 4 December, 2022. After excluding duplicates in the Endnote software, two researchers independently investigated the remaining articles and included all those that used a method for measuring adherence to osteoporosis pharmacotherapy. Articles that did not specify the medications evaluated or if the primary focus was not adherence excluded. Two common measures of adherence, i.e., compliance and persistence were included. Four separate tables were designed, one for direct methods, one for formulas, one for questionnaires, and one for electronic methods of measuring adherence to treatment. Quality assessment was performed for selected articles by the Newcastle-Ottawa Quality Assessment Scale (NOS). A total of 3821 articles were found, of which 178 articles met the inclusion and exclusion criteria. In general, five types of methods were observed to measure medication adherence of osteoporosis, including direct methods (n = 4), pharmacy records (n = 17), questionnaires (n = 13), electronic methods (n = 1), and tablet counting (n = 1). The most commonly used adherence measurement tool, based on pharmacy records, was medication possession ratio (MPR). Among questionnaires, Morisky Medication Adherence Scale was mostly used. Our findings show what tools have been used to measure medication adherence in osteoporosis patients. Among these tools, direct methods and electronic methods are the most accurate methods. However, due to their high cost, they are practically not used in measuring osteoporosis medication adherence. Questionnaires are the most popular among them and are mostly used in osteoporosis.
Identifiants
pubmed: 37286664
doi: 10.1007/s00198-023-06789-5
pii: 10.1007/s00198-023-06789-5
doi:
Substances chimiques
Bone Density Conservation Agents
0
Types de publication
Systematic Review
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1535-1548Informations de copyright
© 2023. International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation.
Références
Tu KN, Lie JD, Wan CKV, Cameron M, Austel AG, Nguyen JK et al (2018) Osteoporosis: a review of treatment options. Pharm Ther 43(2):92
Eastell R (1998) Treatment of postmenopausal osteoporosis. N Engl J Med 338(11):736–746
pubmed: 9494151
doi: 10.1056/NEJM199803123381107
FallahMehrabadi E, Pakgohar M, Asadi S, Haghani H (2017) Lifestyle of elderly people with osteoporosis and its related factors. Iranian J Ageing 12(2):132–145
Vijayakumar R, Büsselberg D (2016) Osteoporosis: an under-recognized public health problem: local and global risk factors and its regional and worldwide prevalence. J Local Global Health Sci 2016(1):2
doi: 10.5339/jlghs.2016.2
Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. The Lancet 359(9319):1761–1767
doi: 10.1016/S0140-6736(02)08657-9
Gupta P, Johnson JT, Cherian KE, Asha HS, Kapoor N, Paul TV (2020) Secondary osteoporosis: case-based review. Curr Med Issues 18(3):229
doi: 10.4103/cmi.cmi_60_20
Nie B, Chapman SC, Chen Z, Wang X, Wei L (2019) Utilization of the beliefs about medicine questionnaire and prediction of medication adherence in China: a systematic review and meta-analysis. J Psychosom Res 122:54–68
pubmed: 31006535
doi: 10.1016/j.jpsychores.2019.03.184
Rosen CJ (2020) The epidemiology and pathogenesis of osteoporosis. In: Feingold KR, Anawalt B, Blackman MR et al (eds) Endotext [Internet]. MDText.com, Inc., South Dartmouth, MA. Available from: https://www.ncbi.nlm.nih.gov/sites/books/NBK279134/
Papaioannou A, Kennedy CC, Dolovich L, Lau E, Adachi JD (2007) Patient adherence to osteoporosis medications. Drugs Aging 24(1):37–55
pubmed: 17233546
doi: 10.2165/00002512-200724010-00003
Weycker D, Macarios D, Edelsberg J, Oster G (2006) Compliance with drug therapy for postmenopausal osteoporosis. Osteoporos Int 17(11):1645–1652
pubmed: 16862397
doi: 10.1007/s00198-006-0179-x
Kothawala P, Badamgarav E, Ryu S, Miller RM, Halbert R (2007) Systematic review and meta-analysis of real-world adherence to drug therapy for osteoporosis. Mayo Clin Proc 82(12):1493–501
pubmed: 18053457
doi: 10.1016/S0025-6196(11)61093-8
Morley J, Moayyeri A, Ali L, Taylor A, Feudjo-Tepie M, Hamilton L et al (2020) Persistence and compliance with osteoporosis therapies among postmenopausal women in the UK Clinical Practice Research Datalink. Osteoporos Int 31(3):533–545
pubmed: 31758206
doi: 10.1007/s00198-019-05228-8
Fahimfar N, Noorali S, Yousefi S, Gharibzadeh S, Shafiee G, Panahi N et al (2021) Prevalence of osteoporosis among the elderly population of Iran. Arch Osteoporos 16(1):16
pubmed: 33475880
doi: 10.1007/s11657-020-00872-8
Addo B, Sencherey S, Babayara MNK (2018) Medication noncompliance among patients with chronic diseases attending a primary health facility in a Periurban District in Ghana. Int J Chron Dis 2018:7187284
Yeam C, Chia S, Tan H, Kwan Y, Fong W, Seng J (2018) A systematic review of factors affecting medication adherence among patients with osteoporosis. Osteoporos Int 29(12):2623–2637
pubmed: 30417253
doi: 10.1007/s00198-018-4759-3
Hiligsmann M, Boonen A, Rabenda V, Reginster J-Y (2012) The importance of integrating medication adherence into pharmacoeconomic analyses: the example of osteoporosis. Expert Rev Pharmacoecon Outcomes Res 12(2):159–166
pubmed: 22458617
doi: 10.1586/erp.12.8
Naik-Panvelkar P, Norman S, Elgebaly Z, Elliott J, Pollack A, Thistlethwaite J et al (2020) Osteoporosis management in Australian general practice: an analysis of current osteoporosis treatment patterns and gaps in practice. BMC Fam Pract 21(1):1–13
doi: 10.1186/s12875-020-01103-2
Alsous M, Alhalaiqa F, Abu Farha R, Abdel Jalil M, McElnay J, Horne R (2017) Reliability and validity of Arabic translation of Medication Adherence Report Scale (MARS) and Beliefs about Medication Questionnaire (BMQ)–specific for use in children and their parents. PLoS ONE 12(2):e0171863
pubmed: 28192467
pmcid: 5305281
doi: 10.1371/journal.pone.0171863
Koller G, Goetz V, Vandermeer B, Homik J, McAlister F, Kendler D et al (2020) Persistence and adherence to parenteral osteoporosis therapies: a systematic review. Osteo Int 31(11):2093–102
doi: 10.1007/s00198-020-05507-9
Jaleel A, Saag KG, Danila MI (2018) Improving drug adherence in osteoporosis: an update on more recent studies. Ther Adv Musculoskelet Dis 10(7):141–149
pubmed: 30023009
pmcid: 6047244
doi: 10.1177/1759720X18785539
Senay A, Fernandes JC, Delisle J, Morin SN, Perreault S (2019) Persistence and compliance to osteoporosis therapy in a fracture liaison service: a prospective cohort study. Arch Osteoporos 14(1):1–11
doi: 10.1007/s11657-019-0633-y
Monnette A, Zhang Y, Shao H, Shi L (2018) Concordance of adherence measurement using self-reported adherence questionnaires and medication monitoring devices: an updated review. Pharmacoeconomics 36(1):17–27
pubmed: 28895104
doi: 10.1007/s40273-017-0570-9
La Caze A, Cottrell N (2016) Validated adherence scales used in a measurement-guided medication management approach to target and tailor a medication adherence intervention: a randomised controlled trial. BMJ Open 6(11):e013375
pubmed: 27903564
pmcid: 5168495
doi: 10.1136/bmjopen-2016-013375
Ahmadizadeh MJ, Ebadi A (2019) Development and psychometric evaluation of the treatment adherence questionnaire for patients with combat post-traumatic stress disorder. Patient Prefer Adherence 13:419
pubmed: 30962678
pmcid: 6434911
doi: 10.2147/PPA.S175353
Al-Hassany L, Kloosterboer SM, Dierckx B, Koch BC (2019) Assessing methods of measuring medication adherence in chronically ill children–a narrative review. Patient Prefer Adherence 13:1175
pubmed: 31413546
pmcid: 6660631
doi: 10.2147/PPA.S200058
McRae-Clark AL, Baker NL, Sonne SC, DeVane CL, Wagner A, Norton J (2015) Concordance of direct and indirect measures of medication adherence in a treatment trial for cannabis dependence. J Subst Abuse Treat 57:70–74
pubmed: 26028133
pmcid: 4561011
doi: 10.1016/j.jsat.2015.05.002
Morisky DE, Green LW, Levine DM (1986) Concurrent and predictive validity of a self-reported measure of medication adherence. Med Care 24(1):67–74
pubmed: 3945130
doi: 10.1097/00005650-198601000-00007
Cabral AC, Moura-Ramos M, Castel-Branco M, Caramona M, Fernandez-Llimos F, Figueiredo IV (2017) Influence of the mode of administration on the results of medication adherence questionnaires. J Eval Clin Pract 23(6):1252–1257
pubmed: 28714551
doi: 10.1111/jep.12773
Chan AHY, Horne R, Hankins M, Chisari C (2020) The medication adherence report scale: a measurement tool for eliciting patients’ reports of nonadherence. Br J Clin Pharmacol 86(7):1281–1288
pubmed: 31823381
pmcid: 7319010
doi: 10.1111/bcp.14193
Karve S, Cleves MA, Helm M, Hudson TJ, West DS, Martin BC (2009) Prospective validation of eight different adherence measures for use with administrative claims data among patients with schizophrenia. Value Health 12(6):989–995
pubmed: 19402852
doi: 10.1111/j.1524-4733.2009.00543.x
Foster BJ, Pai A, Zhao H, Furth S (2014) The TAKE-IT study: aims, design, and methods. BMC Nephrol 15(1):1–9
doi: 10.1186/1471-2369-15-139
Lam WY, Fresco P (2015) Medication adherence measures: an overview. BioMed Res Int 2015:217047
Medication Adherence and Persistence Special Interest Group 2021. Available from: https://www.ispor.org/member-groups/special-interest-groups/medication-adherence-and-persistence . Accessed 28 May 2022
Liu S, Liao E, Wu X, Cao X, Shan P, Su X (2006) Age-related and menopause-related changes of urinary excretion of C-and N-terminal cross-linked telopeptides of type I collagen and the relationships thereof with menopause-related bone loss. Zhonghua Yi Xue Za Zhi 86(6):371–375
pubmed: 16677543
Eastell R, Vrijens B, Cahall DL, Ringe JD, Garnero P, Watts NB (2011) Bone turnover markers and bone mineral density response with risedronate therapy: relationship with fracture risk and patient adherence. J Bone Mineral Res 26(7):1662–1669
doi: 10.1002/jbmr.342
Yamashita M (2016) Urinary cross-linked N-terminal telopeptide of type I collagen levels of infants with Osteogenesis Imperfecta and healthy infants
Chubb SP (2012) Measurement of C-terminal telopeptide of type I collagen (CTX) in serum. Clin Biochem 45(12):928–935
pubmed: 22504058
doi: 10.1016/j.clinbiochem.2012.03.035
Eastell R, Vrijens B, Cahall DL, Ringe JD, Garnero P, Watts NB (2011) Bone turnover markers and bone mineral density response with risedronate therapy: relationship with fracture risk and patient adherence. J Bone Miner Res 26(7):1662–1669
pubmed: 21312265
doi: 10.1002/jbmr.342
Geusens P, Hochberg MC, van der Voort DJ, Pols H, van der Klift M, Siris E et al (2002) editors. Performance of risk indices for identifying low bone density in postmenopausal women. Mayo Clinic Proceedings; Elsevier
Sperber CM, Samarasinghe SR, Lomax GP (2017) An upper and lower bound of the medication possession ratio. Patient Prefer Adherence 11:1469
pubmed: 28919719
pmcid: 5590759
doi: 10.2147/PPA.S136890
Nau DP (2012) Proportion of days covered (PDC) as a preferred method of measuring medication adherence. Pharmacy Quality Alliance, Springfield, VA
Lee JY, Kusek JW, Greene PG, Bernhard S, Norris K, Smith D et al (1996) Assessing medication adherence by pill count and electronic monitoring in the African American Study of Kidney Disease and Hypertension (AASK) Pilot Study. Am J Hypertens 9(8):719–725
pubmed: 8862216
doi: 10.1016/0895-7061(96)00056-8
Svarstad BL, Chewning BA, Sleath BL, Claesson C (1999) The Brief Medication Questionnaire: a tool for screening patient adherence and barriers to adherence. Patient Educ Couns 37(2):113–124
pubmed: 14528539
doi: 10.1016/S0738-3991(98)00107-4
Jiménez V, ML FF (1992) Descriptive study of patient compliance in pharmacologic antihypertensive treatment and validation of the Morisky and Green test. Atencion Primaria. 10(5):767–70
McHorney CA (2009) The adherence estimator: a brief, proximal screener for patient propensity to adhere to prescription medications for chronic disease. Curr Med Res Opin 25(1):215–238
pubmed: 19210154
doi: 10.1185/03007990802619425
Carr A, Hughes R, Vincent K, Carr M, Thwaites C (2004) editors. The impact and implications of new treatments in arthritis: validation of a questionnaire to measure the ‘real life’effectiveness of medication. rheumatology; oxford univ press great clarendon st, Oxford ox2 6DP, ENGLAND
Breuil V, Cortet B, Cotté F-E, Arnould B, Dias-Barbosa C, Gaudin A-F et al (2012) Validation of the adherence evaluation of osteoporosis treatment (ADEOS) questionnaire for osteoporotic post-menopausal women. Osteoporos Int 23(2):445–455
pubmed: 21625889
doi: 10.1007/s00198-011-1555-8
Reynolds K, Viswanathan HN, Muntner P, Harrison TN, Cheetham TC, Hsu J-WY et al (2014) Validation of the Osteoporosis-Specific Morisky Medication Adherence Scale in long-term users of bisphosphonates. Quality Life Res 23(7):2109–20
doi: 10.1007/s11136-014-0662-3
Atkinson MJ, Sinha A, Hass SL, Colman SS, Kumar RN, Brod M et al (2004) Validation of a general measure of treatment satisfaction, the Treatment Satisfaction Questionnaire for Medication (TSQM), using a national panel study of chronic disease. Health Qual Life Outcomes 2(1):1–13
doi: 10.1186/1477-7525-2-1
Thompson K, Kulkarni J, Sergejew A (2000) Reliability and validity of a new Medication Adherence Rating Scale (MARS) for the psychoses. Schizophr Res 42(3):241–247
pubmed: 10785582
doi: 10.1016/S0920-9964(99)00130-9
El Alili M, Vrijens B, Demonceau J, Evers SM, Hiligsmann M (2016) A scoping review of studies comparing the medication event monitoring system (MEMS) with alternative methods for measuring medication adherence. Br J Clin Pharmacol 82(1):268–279
pubmed: 27005306
pmcid: 4917812
doi: 10.1111/bcp.12942
Hawkshead J, Krousel-Wood MA (2007) Techniques for measuring medication adherence in hypertensive patients in outpatient settings. Dis Manag Health Out 15(2):109–118
doi: 10.2165/00115677-200715020-00006
Basu S, Garg S, Sharma N, Singh MM (2019) Improving the assessment of medication adherence: challenges and considerations with a focus on low-resource settings. Tzu-Chi Med J 31(2):73
pmcid: 6450154
doi: 10.4103/tcmj.tcmj_177_18
Culig J, Leppee M (2014) From Morisky to Hill-bone; self-reports scales for measuring adherence to medication. Coll Antropol 38(1):55–62
pubmed: 24851597
Lehmann A, Aslani P, Ahmed R, Celio J, Gauchet A, Bedouch P et al (2014) Assessing medication adherence: options to consider. Int J Clin Pharm 36(1):55–69
pubmed: 24166659
doi: 10.1007/s11096-013-9865-x
Clowes JA, Peel NF, Eastell R (2004) The impact of monitoring on adherence and persistence with antiresorptive treatment for postmenopausal osteoporosis: a randomized controlled trial. J Clin Endocrinol Metab 89(3):1117–1123
pubmed: 15001596
doi: 10.1210/jc.2003-030501
Karve S, Cleves MA, Helm M, Hudson TJ, West DS, Martin BC (2009) Good and poor adherence: optimal cut-point for adherence measures using administrative claims data. Curr Med Res Opin 25(9):2303–2310
pubmed: 19635045
doi: 10.1185/03007990903126833
Bijlsma MJ, Janssen F, Hak E (2016) Estimating time-varying drug adherence using electronic records: extending the proportion of days covered (PDC) method. Pharmacoepidemiol Drug Saf 25(3):325–332
pubmed: 26687394
doi: 10.1002/pds.3935
Allmark P (2005) Bayes and health care research. Med Health Care Philos 7(3):321–332
doi: 10.1007/s11019-004-0804-4
Fairman KA, Motheral B (2000) Evaluating medication adherence: which measure is right for your program? J Manag Care Pharm 6(6):499–506
Durand H, Hayes P, Harhen B, Conneely A, Finn DP, Casey M et al (2018) Medication adherence for resistant hypertension: assessing theoretical predictors of adherence using direct and indirect adherence measures. Br J Health Psychol 23(4):949–966
pubmed: 30014548
doi: 10.1111/bjhp.12332
Tegegn HG, D’Espaignet ET, Wark S, Spark MJ (2020) Self-reported medication adherence tools in cardiovascular disease: protocol for a systematic review of measurement properties. JBI Evid Synth 18(7):1546–1556
pubmed: 32813394
Morisky DE, DiMatteo MR (2011) Improving the measurement of self-reported medication nonadherence: response to authors. J Clin Epidemiol 64(3):255–257
pubmed: 21144706
doi: 10.1016/j.jclinepi.2010.09.002