Molecular Imaging of Myocardial Fibroblast Activation in Patients with Advanced Aortic Stenosis Before Transcatheter Aortic Valve Replacement: A Pilot Study.
Humans
Transcatheter Aortic Valve Replacement
/ methods
Pilot Projects
Stroke Volume
/ physiology
Ventricular Function, Left
/ physiology
Gallium Radioisotopes
Natriuretic Peptide, Brain
Treatment Outcome
Aortic Valve Stenosis
/ diagnostic imaging
Hypertension
/ surgery
Molecular Imaging
Fibroblasts
Aortic Valve
/ diagnostic imaging
PET
aortic stenosis
fibroblast activation protein
molecular imaging
myocardial fibrosis
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
07
11
2022
revised:
10
04
2023
medline:
3
8
2023
pubmed:
9
6
2023
entrez:
8
6
2023
Statut:
ppublish
Résumé
Using multimodal imaging, we investigated the extent and functional correlates of myocardial fibroblast activation in patients with aortic stenosis (AS) scheduled for transcatheter aortic valve replacement (TAVR). AS may cause myocardial fibrosis, which is associated with disease progression and may limit response to TAVR. Novel radiopharmaceuticals identify upregulation of fibroblast activation protein (FAP) as a cellular substrate of cardiac profibrotic activity.
Identifiants
pubmed: 37290793
pii: jnumed.122.265147
doi: 10.2967/jnumed.122.265147
doi:
Substances chimiques
Gallium Radioisotopes
0
Natriuretic Peptide, Brain
114471-18-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1279-1286Informations de copyright
© 2023 by the Society of Nuclear Medicine and Molecular Imaging.