Hmrbase2: a comprehensive database of hormones and their receptors.
Hormone receptors
Hormones
Knowledgebase
Non-peptide hormones
Peptide hormones
Steroid hormones
Journal
Hormones (Athens, Greece)
ISSN: 2520-8721
Titre abrégé: Hormones (Athens)
Pays: Switzerland
ID NLM: 101142469
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
15
03
2023
accepted:
19
05
2023
medline:
25
8
2023
pubmed:
9
6
2023
entrez:
8
6
2023
Statut:
ppublish
Résumé
Hormones play a critical role in regulating various physiological processes and any hormonal imbalances can lead to major endocrine disorders. Thus, studying hormones is essential for both the therapeutics and the diagnostics of hormonal diseases. To facilitate this need, we have developed Hmrbase2, a comprehensive platform that provides extensive information on hormones. Hmrbase2 is a web-based database which is an update of a previously published database, Hmrbase ( http://crdd.osdd.net/raghava/hmrbase/ ). We collected a large amount of information on peptide and non-peptide hormones and hormone receptors, this information being sourced from Hmrbase, HMDB, UniProt, HORDB, ENDONET, PubChem, and the medical literature. Hmrbase2 contains a total of 12,056 entries, which is more than twice the number of entries contained in the previous version Hmrbase. These include 7406, 753, and 3897 entries for peptide hormones, non-peptide hormones, and hormone receptors, respectively, from 803 organisms compared to the 562 organisms in the previous version. The database also hosts 5662 hormone receptor pairs. The source organism, function, and subcellular location are provided for peptide hormones and receptors and properties such as melting point and water solubility is provided for non-peptide hormones. Besides browsing and keyword search, an advanced search option has also been supplied. Additionally, a similarity search module has been incorporated enabling users to run similarity searches against peptide hormone sequences using BLAST and Smith-Waterman. To make the database accessible to various users, we designed a user-friendly, responsive website that can be easily used on smartphones, tablets, and desktop computers. The updated database version, Hmrbase2, offers improved data content compared to the previous version. Hmrbase2 is freely available at https://webs.iiitd.edu.in/raghava/hmrbase2 .
Identifiants
pubmed: 37291365
doi: 10.1007/s42000-023-00455-5
pii: 10.1007/s42000-023-00455-5
doi:
Substances chimiques
Hormones
0
Peptide Hormones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
359-366Subventions
Organisme : Department of Biotechnology, Ministry of Science and Technology, India
ID : BT/PR40158/BTIS/137/24/2021
Informations de copyright
© 2023. The Author(s), under exclusive licence to Hellenic Endocrine Society.
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