Perinatal and postnatal exposure to phthalates and early neurodevelopment at 6 months in healthy infants born at term.
Griffiths development scales
endocrine disruptors
infants
neurodevelopment
newborns
perinatal exposure
phthalates
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
23
02
2023
accepted:
08
05
2023
medline:
12
6
2023
pubmed:
9
6
2023
entrez:
9
6
2023
Statut:
epublish
Résumé
Phthalates are non-persistent chemicals largely used as plasticizers and considered ubiquitous pollutants with endocrine disrupting activity. The exposure during sensible temporal windows as pregnancy and early childhood, may influence physiological neurodevelopment. The aim of this study is to analyze the relationship between the urinary levels of phthalate metabolites in newborn and infants and the global development measured by the Griffiths Scales of Children Development (GSCD) at six months. Longitudinal cohort study in healthy Italian term newborn and their mothers from birth to the first 6 months of life. Urine samples were collected at respectively 0 (T0), 3 (T3), 6 (T6) months, and around the delivery for mothers. Urine samples were analyzed for a total of 7 major phthalate metabolites of 5 of the most commonly used phthalates. At six months of age a global child development assessment using the third edition of the Griffith Scales of Child Development (GSCD III) was performed in 104 participants. In a total of 387 urine samples, the seven metabolites analyzed appeared widespread and were detected in most of the urine samples collected at any time of sampling (66-100%). At six months most of the Developmental Quotients (DQs) falls in average range, except for the subscale B, which presents a DQ median score of 87 (85-95). Adjusted linear regressions between DQs and urinary phthalate metabolite concentrations in mothers at T0 and in infants at T0, T3 and T6 identified several negative associations both for infants' and mothers especially for DEHP and MBzP. Moreover, once stratified by children's sex, negative associations were found in boys while positive in girls. Phthalates exposure is widespread, especially for not regulated compounds. Urinary phthalate metabolites were found to be associated to GSCD III scores, showing inverse association with higher phthalate levels related to lower development scores. Our data suggested differences related to the child's sex.
Sections du résumé
Background
UNASSIGNED
Phthalates are non-persistent chemicals largely used as plasticizers and considered ubiquitous pollutants with endocrine disrupting activity. The exposure during sensible temporal windows as pregnancy and early childhood, may influence physiological neurodevelopment.
Aims and Scope
UNASSIGNED
The aim of this study is to analyze the relationship between the urinary levels of phthalate metabolites in newborn and infants and the global development measured by the Griffiths Scales of Children Development (GSCD) at six months.
Methods
UNASSIGNED
Longitudinal cohort study in healthy Italian term newborn and their mothers from birth to the first 6 months of life. Urine samples were collected at respectively 0 (T0), 3 (T3), 6 (T6) months, and around the delivery for mothers. Urine samples were analyzed for a total of 7 major phthalate metabolites of 5 of the most commonly used phthalates. At six months of age a global child development assessment using the third edition of the Griffith Scales of Child Development (GSCD III) was performed in 104 participants.
Results
UNASSIGNED
In a total of 387 urine samples, the seven metabolites analyzed appeared widespread and were detected in most of the urine samples collected at any time of sampling (66-100%). At six months most of the Developmental Quotients (DQs) falls in average range, except for the subscale B, which presents a DQ median score of 87 (85-95). Adjusted linear regressions between DQs and urinary phthalate metabolite concentrations in mothers at T0 and in infants at T0, T3 and T6 identified several negative associations both for infants' and mothers especially for DEHP and MBzP. Moreover, once stratified by children's sex, negative associations were found in boys while positive in girls.
Conclusions
UNASSIGNED
Phthalates exposure is widespread, especially for not regulated compounds. Urinary phthalate metabolites were found to be associated to GSCD III scores, showing inverse association with higher phthalate levels related to lower development scores. Our data suggested differences related to the child's sex.
Identifiants
pubmed: 37293488
doi: 10.3389/fendo.2023.1172743
pmc: PMC10244530
doi:
Substances chimiques
phthalic acid
6O7F7IX66E
Phthalic Acids
0
Environmental Pollutants
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1172743Informations de copyright
Copyright © 2023 Lucaccioni, Palandri, Passini, Trevisani, Calandra Buonaura, Bertoncelli, Talucci, Ferrari, Ferrari, Predieri, Facchinetti, Iughetti and Righi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Mol Nutr Food Res. 2011 Jan;55(1):7-31
pubmed: 20564479
Sci Total Environ. 2015 Jun 1;517:125-31
pubmed: 25725197
Neurotoxicol Teratol. 2023 Mar-Apr;96:107161
pubmed: 36690047
Eur J Pediatr. 2023 Mar;182(3):1173-1181
pubmed: 36604347
Environ Health Perspect. 2011 Oct;119(10):1495-500
pubmed: 21737372
Curr Opin Pediatr. 2020 Aug;32(4):554-559
pubmed: 32692053
Neurotoxicology. 2019 Jul;73:199-212
pubmed: 31004626
Nat Rev Endocrinol. 2017 Mar;13(3):161-173
pubmed: 27857130
Am J Public Health. 2021 Apr;111(4):551-552
pubmed: 33689442
Lancet Diabetes Endocrinol. 2020 Aug;8(8):703-718
pubmed: 32707118
World J Biol Chem. 2017 May 26;8(2):108-119
pubmed: 28588754
BMC Pediatr. 2019 Dec 12;19(1):489
pubmed: 31830946
Environ Pollut. 2021 Dec 15;291:118106
pubmed: 34520948
Mol Nutr Food Res. 2007 Jul;51(7):899-911
pubmed: 17604388
Cogn Neurosci. 2021 Jul-Oct;12(3-4):155-162
pubmed: 32902364
Neurotoxicology. 2015 May;48:21-34
pubmed: 25749100
J Neuroendocrinol. 2004 Oct;16(10):809-18
pubmed: 15500540
Infant Behav Dev. 2019 Nov;57:101352
pubmed: 31445432
J Steroid Biochem. 1980 Jan;12:25-36
pubmed: 6448322
Environ Pollut. 2021 Feb 15;271:116380
pubmed: 33387779
Br J Nutr. 2013 Mar 28;109(6):1105-8
pubmed: 22784704
Am J Public Health. 2021 Apr;111(4):687-695
pubmed: 33600256
Neurotoxicology. 2020 Sep;80:20-28
pubmed: 32479765
Int J Hyg Environ Health. 2007 Oct;210(5):623-34
pubmed: 17889607
PLoS One. 2013 Apr 23;8(4):e62442
pubmed: 23626820
Am J Clin Nutr. 1996 Mar;63(3 Suppl):448S-451S
pubmed: 8615340
Environ Health Perspect. 2015 Mar;123(3):210-6
pubmed: 25402001
PLoS One. 2014 Dec 10;9(12):e114003
pubmed: 25493564
Environ Res. 2019 May;172:604-614
pubmed: 30878731
Toxics. 2019 Apr 05;7(2):
pubmed: 30959800
Environ Health Perspect. 2022 Apr;130(4):47006
pubmed: 35452257
Pediatrics. 2003 Jun;111(6 Pt 1):1467-74
pubmed: 12777573
Eur J Obstet Gynecol Reprod Biol. 2019 Sep;240:293-299
pubmed: 31400564
Early Hum Dev. 2006 Apr;82(4):257-66
pubmed: 16360292
Int J Hyg Environ Health. 2014 Jan;217(1):78-87
pubmed: 23623597
Environ Health Perspect. 2019 Oct;127(10):107010
pubmed: 31652105
Int J Public Health. 2022 Jun 20;67:1604804
pubmed: 35795098
Toxicol Res (Camb). 2017 Apr 26;6(4):505-520
pubmed: 30090519
Curr Probl Pediatr Adolesc Health Care. 2008 Feb;38(2):34-49
pubmed: 18237855
Neonatology. 2018;114(2):169-176
pubmed: 29898453
Int J Mol Sci. 2021 Apr 14;22(8):
pubmed: 33920043
Environ Res. 2008 Feb;106(2):257-69
pubmed: 17976571
Best Pract Res Clin Endocrinol Metab. 2021 Sep;35(5):101478
pubmed: 33608224
Environ Health. 2019 Aug 30;18(1):80
pubmed: 31470855
J Hazard Mater. 2017 Oct 15;340:360-383
pubmed: 28800814
Front Public Health. 2020 Aug 28;8:366
pubmed: 32984231
Toxics. 2023 Jan 11;11(1):
pubmed: 36668792
Int J Obes Relat Metab Disord. 1997 Nov;21(11):1082-4
pubmed: 9368835
Front Psychol. 2022 Nov 07;13:874264
pubmed: 36420380
Environ Res. 2023 Feb 15;219:115068
pubmed: 36528043
Early Hum Dev. 2014 Sep;90(9):477-85
pubmed: 25038557
Int J Hyg Environ Health. 2007 Jan;210(1):21-33
pubmed: 17182278
J Clin Endocrinol Metab. 2017 Jun 1;102(6):1870-1878
pubmed: 28324030
Child Care Health Dev. 2010 May;36(3):354-60
pubmed: 20507327