Lu AF35700 reverses the phencyclidine-induced disruption of thalamo-cortical activity by blocking dopamine D

Rats Animals Phencyclidine / pharmacology Clozapine / pharmacology Haloperidol / pharmacology Dopamine Antipsychotic Agents / pharmacology Dopamine Antagonists / pharmacology Receptors, Dopamine D1
D(1) receptor D(2) receptor Phencyclidine Thalamo-cortical activity cfos

Journal

European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354

Informations de publication

Date de publication:
15 Aug 2023
Historique:
received: 14 02 2023
revised: 16 05 2023
accepted: 17 05 2023
medline: 30 6 2023
pubmed: 10 6 2023
entrez: 9 6 2023
Statut: ppublish

Résumé

Antipsychotic drugs of different chemical/pharmacological families show preferential dopamine (DA) D

Identifiants

DOI: 10.1016/j.ejphar.2023.175802 PMID: 37295763
pubmed: 37295763
pii: S0014-2999(23)00313-8
doi: 10.1016/j.ejphar.2023.175802
pii:
doi:

Substances chimiques

Phencyclidine J1DOI7UV76
Clozapine J60AR2IKIC
Haloperidol J6292F8L3D
Dopamine VTD58H1Z2X
Lu AF35700 0
Antipsychotic Agents 0
Dopamine Antagonists 0
Receptors, Dopamine D1 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

175802

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest FA and PC were PI and co-PI from a grant from Lundbeck A/S FA has also received educational fees from Lundbeck A/S. MD is a Lundbeck A/S employee. The rest of authors declares no conflict of interest.

Auteurs

Maurizio S Riga (MS)

Department of Neuroscience and Experimental Therapeutics, CSIC-Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: mauririga@gmail.com.

Veronica Paz (V)

Department of Neuroscience and Experimental Therapeutics, CSIC-Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.

Michael Didriksen (M)

H. Lundbeck A/S, Synaptic Transmission, Neuroscience Research DK, Valby, Denmark.

Pau Celada (P)

Department of Neuroscience and Experimental Therapeutics, CSIC-Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.

Francesc Artigas (F)

Department of Neuroscience and Experimental Therapeutics, CSIC-Institut d'Investigacions Biomèdiques de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Lu AF35700 reverses the phencyclidine-induced...
questionsmedicales.fr › Eucaryotes › Animaux › Lu AF35700 reverses the phencyclidine-induced...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Phencyclidine › Lu AF35700 reverses the phencyclidine-induced...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Dibenzazépines › Clozapine › Lu AF35700 reverses the phencyclidine-induced...
questionsmedicales.fr › Composés chimiques organiques › Cétones › Butyrophénones › Halopéridol › Lu AF35700 reverses the phencyclidine-induced...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Dopamine › Lu AF35700 reverses the phencyclidine-induced...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Tranquillisants › Neuroleptiques › Lu AF35700 reverses the phencyclidine-induced...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents dopaminergiques › Antagonistes de la dopamine › Lu AF35700 reverses the phencyclidine-induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs catécholaminergiques › Récepteurs dopaminergiques › Récepteur dopamine D1 › Lu AF35700 reverses the phencyclidine-induced...