DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo.
APOBEC3A
DNA deamination
DNA mutation
RNA editing
carcinogenesis
hepatocellular carcinoma
molecular mechanism
tumorigenesis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 May 2023
26 May 2023
Historique:
received:
28
04
2023
revised:
20
05
2023
accepted:
22
05
2023
medline:
12
6
2023
pubmed:
10
6
2023
entrez:
10
6
2023
Statut:
epublish
Résumé
Although the APOBEC3 family of single-stranded DNA cytosine deaminases is well-known for its antiviral factors, these enzymes are rapidly gaining attention as prominent sources of mutation in cancer. APOBEC3's signature single-base substitutions, C-to-T and C-to-G in TCA and TCT motifs, are evident in over 70% of human malignancies and dominate the mutational landscape of numerous individual tumors. Recent murine studies have established cause-and-effect relationships, with both human APOBEC3A and APOBEC3B proving capable of promoting tumor formation in vivo. Here, we investigate the molecular mechanism of APOBEC3A-driven tumor development using the murine
Identifiants
pubmed: 37298259
pii: ijms24119305
doi: 10.3390/ijms24119305
pmc: PMC10253583
pii:
doi:
Substances chimiques
APOBEC3A protein, human
EC 3.5.4.5
Cytidine Deaminase
EC 3.5.4.5
DNA
9007-49-2
APOBEC3B protein, human
EC 3.5.4.5
Minor Histocompatibility Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : P01 CA234228
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM118047
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM140936
Pays : United States
Organisme : NCI NIH HHS
ID : P01-CA234228
Pays : United States
Références
Mod Pathol. 2021 Feb;34(2):280-290
pubmed: 32632179
Nucleic Acids Res. 1996 Feb 1;24(3):478-85
pubmed: 8602361
J Virol. 2018 May 14;92(11):
pubmed: 29593034
Cell Cycle. 2016;15(7):998-1008
pubmed: 26918916
Nat Commun. 2016 Sep 21;7:12918
pubmed: 27650891
Nat Commun. 2017 Dec 4;8(1):1922
pubmed: 29203771
Nature. 2022 Jul;607(7920):799-807
pubmed: 35859169
Nat Commun. 2020 Jun 12;11(1):2971
pubmed: 32532990
Nat Genet. 2014 May;46(5):487-91
pubmed: 24728294
Blood. 2018 Sep 20;132(12):1304-1317
pubmed: 30061158
Sci Rep. 2017 Apr 21;7:46719
pubmed: 28429755
J Mol Biol. 2012 Jun 22;419(5):301-14
pubmed: 22446380
Cancer Res. 2017 Sep 1;77(17):4567-4578
pubmed: 28698210
Oncogene. 2016 Aug 18;35(33):4407-13
pubmed: 26640150
Hepatology. 2011 Mar;53(3):781-90
pubmed: 21374658
Nat Commun. 2015 Apr 21;6:6881
pubmed: 25898173
Nature. 2002 Jul 4;418(6893):99-103
pubmed: 12097915
Cancer Res. 2022 Oct 04;82(19):3435-3448
pubmed: 35930804
Nat Biotechnol. 2009 Mar;27(3):264-74
pubmed: 19234449
Nat Rev Cancer. 2017 Jun;17(6):381-392
pubmed: 28416802
Mol Cell. 2002 Nov;10(5):1247-53
pubmed: 12453430
PLoS One. 2017 Jan 31;12(1):e0171343
pubmed: 28141868
Nature. 2016 May 02;534(7605):47-54
pubmed: 27135926
Am J Hum Genet. 2002 Jan;70(1):38-50
pubmed: 11727199
Cancer Discov. 2015 Jul;5(7):704-12
pubmed: 26091828
J Inherit Metab Dis. 1998 Aug;21(5):518-31
pubmed: 9728332
Nat Rev Genet. 2018 Aug;19(8):473-490
pubmed: 29692414
Sci Rep. 2016 Jan 07;6:19035
pubmed: 26738439
Nucleic Acids Res. 2017 Apr 7;45(6):3231-3241
pubmed: 28100701
Am J Hum Genet. 1997 Feb;60(2):305-12
pubmed: 9012403
Nat Rev Cancer. 2021 Oct;21(10):619-637
pubmed: 34316057
Histopathology. 2023 Mar;82(4):608-621
pubmed: 36416305
Hepatology. 2008 May;47(5):1714-24
pubmed: 18435462
Nucleic Acids Res. 2018 Aug 21;46(14):e84
pubmed: 29746667
J Exp Med. 2003 May 5;197(9):1173-81
pubmed: 12732658
Blood Cancer J. 2021 Oct 8;11(10):166
pubmed: 34625538
ACS Synth Biol. 2021 May 21;10(5):1106-1115
pubmed: 33938211
CRISPR J. 2018 Jun;1:239-250
pubmed: 31021262
Nature. 2013 Feb 21;494(7437):366-70
pubmed: 23389445
Nat Rev Cancer. 2014 Dec;14(12):786-800
pubmed: 25568919
J Exp Med. 2020 Dec 7;217(12):
pubmed: 32870257
Viruses. 2013 Jul 30;5(8):1934-47
pubmed: 23903287
Nat Rev Genet. 2022 Aug;23(8):505-518
pubmed: 35256818
RNA Biol. 2021 Nov;18(11):1524-1539
pubmed: 33593231
Clin Cancer Res. 2020 Jul 1;26(13):3397-3407
pubmed: 32060098
Nature. 2013 Aug 22;500(7463):415-21
pubmed: 23945592
PLoS One. 2016 Dec 15;11(12):e0168090
pubmed: 27977754
PLoS Genet. 2019 Dec 16;15(12):e1008545
pubmed: 31841499
Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8483-7
pubmed: 7667315
Nat Commun. 2023 Oct 11;14(1):6382
pubmed: 37821454
Nature. 2013 Feb 28;494(7438):492-496
pubmed: 23446422
Nat Genet. 2013 Sep;45(9):977-83
pubmed: 23852168
Nat Cell Biol. 2014 Jan;16(1):2-9
pubmed: 24366029
Cell Rep Med. 2023 Oct 17;4(10):101211
pubmed: 37797615
Antibodies (Basel). 2019 Sep 10;8(3):
pubmed: 31544853
Sci Rep. 2019 Jan 24;9(1):497
pubmed: 30679582