Relative Humidity and Its Impact on the Immune System and Infections.
allergic rhinitis
asthma
infection
molecular mechanisms
prevention
respiratory diseases
risk factors
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 May 2023
29 May 2023
Historique:
received:
05
05
2023
revised:
24
05
2023
accepted:
25
05
2023
medline:
12
6
2023
pubmed:
10
6
2023
entrez:
10
6
2023
Statut:
epublish
Résumé
Relative humidity (RH) represents an underestimated outdoor and indoor environmental parameter. Conditions below and above the optimal range could facilitate infectious transmission as well as the exacerbation of respiratory diseases. The aim of this review is to outline the consequences for health of suboptimal RH in the environment and how to limit this negative impact. RH primarily affects the rheological properties of the mucus, modifying its osmolarity and thus the mucociliary clearance. The integrity of the physical barrier, maintained by mucus and tight junctions, is critical for protection from pathogens or irritants. Moreover, the control of RH seems to be a strategy to prevent and control the spread of viruses and bacteria. However, the imbalance of RH in the outdoor and indoor environments is frequently associated with the presence of other irritants, allergens, and pathogens, and therefore the burden of a single risk factor is not clearly defined in different situations. Nonetheless, RHmay have a synergistic negative effect with these risk factors, and its normalization, if possible, may have a positive impact on a healthier environment.
Identifiants
pubmed: 37298409
pii: ijms24119456
doi: 10.3390/ijms24119456
pmc: PMC10253274
pii:
doi:
Substances chimiques
Irritants
0
Allergens
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Allergy Clin Immunol. 2017 Jun;139(6):1752-1761
pubmed: 28583447
PLoS One. 2016 May 18;11(5):e0155742
pubmed: 27191186
Heliyon. 2023 Mar 07;9(3):e14271
pubmed: 36942216
Indoor Air. 2004;14 Suppl 7:74-81
pubmed: 15330775
Asian Pac J Allergy Immunol. 2015 Jun;33(2):129-35
pubmed: 26141034
Environ Int. 2023 Feb;172:107786
pubmed: 36738582
Exp Eye Res. 2012 Jan;94(1):150-6
pubmed: 22166618
PLoS One. 2013;8(2):e57485
pubmed: 23460865
Annu Rev Pathol. 2017 Jan 24;12:331-357
pubmed: 27959637
J Eur Acad Dermatol Venereol. 2016 Aug;30(8):1285-94
pubmed: 27306376
J Allergy Clin Immunol. 2018 May;141(5):1553-1560
pubmed: 29731101
Ecotoxicol Environ Saf. 2022 Aug;241:113786
pubmed: 35738102
Infect Dis Poverty. 2021 Dec 23;10(1):139
pubmed: 34937575
Sci Rep. 2021 Nov 15;11(1):22175
pubmed: 34782650
Int J Environ Res Public Health. 2019 Jul 22;16(14):
pubmed: 31336583
Children (Basel). 2021 Nov 19;8(11):
pubmed: 34828780
Environ Sci Pollut Res Int. 2023 Apr;30(20):58041-58057
pubmed: 36977878
Sci Bull (Beijing). 2022 Sep 30;67(18):1833-1836
pubmed: 36546293
Front Cell Infect Microbiol. 2020 May 14;10:213
pubmed: 32477966
Clin Exp Allergy. 2005 Jun;35(6):723-7
pubmed: 15969661
Exp Appl Acarol. 2020 Mar;80(3):381-398
pubmed: 32030607
Environ Res. 2010 May;110(4):372-4
pubmed: 20338555
Clin Transl Allergy. 2022 Feb 02;12(2):e12116
pubmed: 35136540
PLoS One. 2018 Jan 11;13(1):e0191165
pubmed: 29324816
Sci Total Environ. 2017 Mar 1;581-582:750-755
pubmed: 28063655
Clin Exp Allergy. 2008 Aug;38(8):1264-74
pubmed: 18537982
Sci Total Environ. 2021 Nov 1;793:148621
pubmed: 34328976
Environ Health. 2010 Sep 03;9:55
pubmed: 20815876
N Engl J Med. 2005 May 12;352(19):1992-2001
pubmed: 15888700
World Allergy Organ J. 2019 Jul 03;12(7):100046
pubmed: 31320967
J Res Med Sci. 2013 Dec;18(12):1067-73
pubmed: 24523798
Int J Environ Res Public Health. 2021 Dec 24;19(1):
pubmed: 35010425
Int Forum Allergy Rhinol. 2014 May;4(5):361-70
pubmed: 24510479
J Voice. 2022 Mar 29;:
pubmed: 35365386
World Allergy Organ J. 2016 Dec 14;9(1):42
pubmed: 28031774
Int J Environ Health Res. 2022 Mar 5;:1-13
pubmed: 35253533
Exp Physiol. 2021 Jan;106(1):52-64
pubmed: 32386089
Int J Hyg Environ Health. 2021 Apr;233:113709
pubmed: 33601136
Front Immunol. 2021 Aug 13;12:672312
pubmed: 34484176
J Allergy Clin Immunol. 2021 Apr;147(4):1296-1305.e6
pubmed: 32926879
Cochrane Database Syst Rev. 2021 Dec 10;12:CD012219
pubmed: 34891215
Int J Environ Res Public Health. 2017 Oct 17;14(10):
pubmed: 29039816
PLoS Pathog. 2007 Oct 19;3(10):1470-6
pubmed: 17953482
Int J Environ Res Public Health. 2020 Aug 27;17(17):
pubmed: 32867076
Allergy. 2020 Sep;75(9):2219-2228
pubmed: 32589303
Lancet. 2008 Sep 20;372(9643):1049-57
pubmed: 18805333
Eur J Pharm Sci. 2019 May 15;133:137-144
pubmed: 30946963
Can Respir J. 2019 Jun 2;2019:3435103
pubmed: 31281551
J Virol. 2007 Jun;81(11):5429-36
pubmed: 17182688
Allergy Asthma Immunol Res. 2019 Jul;11(4):450-469
pubmed: 31172715
Med Sci Sports Exerc. 2011 Jul;43(7):1207-13
pubmed: 21131866