Polyamine-Drug Conjugates: Do They Boost Drug Activity?
antimicrobial
antitumor
drug conjugate
neuroprotective
polyamine
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
02 Jun 2023
02 Jun 2023
Historique:
received:
16
05
2023
revised:
30
05
2023
accepted:
31
05
2023
medline:
12
6
2023
pubmed:
10
6
2023
entrez:
10
6
2023
Statut:
epublish
Résumé
Over the past two decades, the strategy of conjugating polyamine tails with bioactive molecules such as anticancer and antimicrobial agents, as well as antioxidant and neuroprotective scaffolds, has been widely exploited to enhance their pharmacological profile. Polyamine transport is elevated in many pathological conditions, suggesting that the polyamine portion could improve cellular and subcellular uptake of the conjugate via the polyamine transporter system. In this review, we have presented a glimpse on the polyamine conjugate scenario, classified by therapeutic area, of the last decade with the aim of highlighting achievements and fostering future developments.
Identifiants
pubmed: 37298993
pii: molecules28114518
doi: 10.3390/molecules28114518
pmc: PMC10254200
pii:
doi:
Substances chimiques
Polyamines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Ministry of University and Research (MIUR)
ID : PRIN 2017(2017MT3993_007)
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