Effects of risperidone/paliperidone versus placebo on cognitive functioning over the first 6 months of treatment for psychotic disorder: secondary analysis of a triple-blind randomised clinical trial.


Journal

Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664

Informations de publication

Date de publication:
10 Jun 2023
Historique:
received: 27 01 2023
accepted: 30 05 2023
revised: 17 05 2023
medline: 12 6 2023
pubmed: 11 6 2023
entrez: 10 6 2023
Statut: epublish

Résumé

The drivers of cognitive change following first-episode psychosis remain poorly understood. Evidence regarding the role of antipsychotic medication is primarily based on naturalistic studies or clinical trials without a placebo arm, making it difficult to disentangle illness from medication effects. A secondary analysis of a randomised, triple-blind, placebo-controlled trial, where antipsychotic-naive patients with first-episode psychotic disorder were allocated to receive risperidone/paliperidone or matched placebo plus intensive psychosocial therapy for 6 months was conducted. A healthy control group was also recruited. A cognitive battery was administered at baseline and 6 months. Intention-to-treat analysis involved 76 patients (antipsychotic medication group: 37; 18.6

Identifiants

pubmed: 37301832
doi: 10.1038/s41398-023-02501-7
pii: 10.1038/s41398-023-02501-7
pmc: PMC10257667
doi:

Substances chimiques

Risperidone L6UH7ZF8HC
Antipsychotic Agents 0
Paliperidone Palmitate R8P8USM8FR

Types de publication

Randomized Controlled Trial Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

199

Subventions

Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 1064704

Informations de copyright

© 2023. The Author(s).

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Auteurs

Kelly Allott (K)

Orygen, Parkville, VIC, Australia. kelly.allott@orygen.org.au.
Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia. kelly.allott@orygen.org.au.

Hok Pan Yuen (HP)

Orygen, Parkville, VIC, Australia.
Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.

Lara Baldwin (L)

Orygen, Parkville, VIC, Australia.
Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.

Brian O'Donoghue (B)

Orygen, Parkville, VIC, Australia.
Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Department of Psychiatry, University College Dublin, Belfield, Ireland.

Alex Fornito (A)

Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Clayton, VIC, Australia.
Monash Biomedical Imaging, Monash University, Clayton, VIC, Australia.

Sidhant Chopra (S)

Department of Psychology, Yale University, New Haven, CT, USA.

Barnaby Nelson (B)

Orygen, Parkville, VIC, Australia.
Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.

Jessica Graham (J)

Orygen, Parkville, VIC, Australia.

Melissa J Kerr (MJ)

Orygen, Parkville, VIC, Australia.
Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.

Tina-Marie Proffitt (TM)

Orygen, Parkville, VIC, Australia.

Aswin Ratheesh (A)

Orygen, Parkville, VIC, Australia.
Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.

Mario Alvarez-Jimenez (M)

Orygen, Parkville, VIC, Australia.
Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.

Susy Harrigan (S)

Department of Social Work, School of Primary and Allied Health Care, Monash University, Melbourne, VIC, Australia.
Centre for Mental Health, Melbourne School of Global and Population Health, The University of Melbourne, Parkville, VIC, Australia.

Ellie Brown (E)

Orygen, Parkville, VIC, Australia.
Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.

Andrew D Thompson (AD)

Orygen, Parkville, VIC, Australia.
Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Warwick, UK.

Christos Pantelis (C)

Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia.
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.
NorthWestern Mental Health, Western Hospital Sunshine, St Albans, VIC, Australia.

Michael Berk (M)

Orygen, Parkville, VIC, Australia.
Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, VIC, Australia.

Patrick D McGorry (PD)

Orygen, Parkville, VIC, Australia.
Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.

Shona M Francey (SM)

Orygen, Parkville, VIC, Australia.
Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.

Stephen J Wood (SJ)

Orygen, Parkville, VIC, Australia.
Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia.
School of Psychology, University of Birmingham, Edgbaston, UK.

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