The role of LIN28B in tumor progression and metastasis in solid tumor entities.
Cancer
EMT
LIN28B
Let-7
Metastasis
Resistance
Stemness
Journal
Oncology research
ISSN: 1555-3906
Titre abrégé: Oncol Res
Pays: United States
ID NLM: 9208097
Informations de publication
Date de publication:
2023
2023
Historique:
received:
30
11
2022
accepted:
16
02
2023
medline:
13
6
2023
pubmed:
12
6
2023
entrez:
12
6
2023
Statut:
epublish
Résumé
LIN28B is an RNA-binding protein that targets a broad range of microRNAs and modulates their maturation and activity. Under normal conditions, LIN28B is exclusively expressed in embryogenic stem cells, blocking differentiation and promoting proliferation. In addition, it can play a role in epithelial-to-mesenchymal transition by repressing the biogenesis of let-7 microRNAs. In malignancies, LIN28B is frequently overexpressed, which is associated with increased tumor aggressiveness and metastatic properties. In this review, we discuss the molecular mechanisms of LIN28B in promoting tumor progression and metastasis in solid tumor entities and its potential use as a clinical therapeutic target and biomarker.
Identifiants
pubmed: 37304235
doi: 10.32604/or.2023.028105
pii: 28105
pmc: PMC10208000
doi:
Substances chimiques
MicroRNAs
0
LIN28B protein, human
0
RNA-Binding Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101-115Informations de copyright
© 2023 Gewalt, Noh and Meder.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest to report regarding the present study.
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